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Artificial Intelligence

Basecamp Research launches ZymCTRL a world-first, open source, generative AI tool that designs enzymes for more sustainable industrial processes

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ZymCTRL is the world’s first open-source, text-based enzyme generation model and can be used across multiple industries, including therapeutics and sustainability initiatives.
AI model able to produce sequences that produced functional enzymes with desirable characteristics for industrial applications.
LONDON, June 18, 2024 /PRNewswire/ — Basecamp Research, a world leader in artificial intelligence (AI)-based design of proteins and other biological systems, in partnership with the Ferruz Laboratory at the Institute of Molecular Biology of Barcelona today announced the release of ZymCTRL (“enzyme control”), a ChatGPT-like tool that generates new sequences from scratch based on a user simply typing in an enzyme identification code, which specifies the desired activity.

Large language models (LLMs), such as ChatGPT, have proven useful in helping scientists design and generate protein sequences.. However, current models require further training as well as conditioning on a known protein starter sequence (“seed sequence”) for protein generation.
ZymCTRL is a next-generation end-to-end protein LLM that offers rapid, cost-effective design capabilities for generating artificial enzymes. In contrast to other LLMs, the tool requires no seed sequence, giving end users complete control. Another important feature is ZymCTRL’s ability to create enzyme sequences that work but share only 30% resemblance to those in the training set – expanding the possibilities for designing new enzymes.
“With ZymCtrl, generating highly specific enzymes is as easy as interacting with a chatbot”, said Noelia Ferruz who has been partnering with Basecamp Research for over 2 years. The Ferruz lab is considered a pioneer in the field of AI for protein design, having previously built ProtGPT2. a deep unsupervised language model for protein design.
“Even before the release of ChatGPT,  we began working on large language models with Noelia because we think these models represent the future of biological research and protein design,” said Dr. Philipp Lorenz, CTO of Basecamp Research. “We’re deeply excited by these results and ZymCTRL’s ability to create functional enzymes that can solve some of today’s biggest challenges, from finding new ways to treat devastating diseases to building greener and more sustainable catalytic processes in bioindustry.”
The open source ZymCTRL model has been independently reviewed by academics in Structural Biology and ChemBioChem, peer-reviewed scientific journals. In ChemBioChem, researchers at The Institute of Biochemistry at Austria’s Graz University of Technology, cited ZymCTRL’s efficiency and ease of use. “ZymCtrl designs putative enzyme variants on consumer GPUs within seconds and, remarkably, it creates these sequences with only an EC number as input,” wrote Horst Lechner, principle investigator for the institute, which is focuses on enzyme design that differs from what’s seen in nature.
Basecamp Research is sharing ZymCTRL open source with researchers and sees an array of potential applications, including designing enzymes for disease treatment and diagnostics, biofuel production, sustainable agriculture innovations and much more.
While ZymCTRL was initially trained on publicly available datasets, it can also be integrated with other datasets, including Basecamp Research’s proprietary BaseGraph database, to further optimise the model and improve sequence outputs.
Highlights
ZymCTRL was first trained on the BRENDA enzyme database, comprising 37M enzyme sequences.- From this, the team generated sets of carbonic anhydrases, enzymes that accelerate the conversion of carbon dioxide to bicarbonate, helping capture and store CO2, and lactate dehydrogenases, enzymes that help convert sugar into energy in our cells, with no further fine-tuning for the AI model.After producing and purifying the proteins, several showed enzyme activity despite less than 40% of their sequences resembling proteins seen in the public database. This happened with no additional adjustments to the model.- To correct for potential biases in public databases, which have uneven sampling due a lack of biodiversity, ZymCTRL was adjusted using a wider range of lactate dehydrogenase sequences from Basecamp Research’s proprietary BaseGraph dataset.- With this fine-tuning, the team created lactate dehydrogenases with higher quality scores in silico (in computer simulations), such as better predicted local distance difference test (pLDDT) values, compared to sequences generated with no prior training.Remarkably, active enzymes continued to show significant activity at a high temperature of 45°C as well as across a broad pH range of 4.5 to 9.5 – meaning it can work or stay stable in slightly acidic to slightly basic environments – offering significant industry advantages over naturally-occurring lactate dehydrogenases. This excellent pH tolerance allows a single enzyme to be used in many different processes with different pH levels, making the enzyme very useful and adaptable for many applications.Two of the artificial lactate dehydrogenase enzymes were produced in larger amounts and successfully freeze-dried. They kept their activity and showed they could work in complex reactions under harsh conditions, supporting their potential for industrial use.”Beyond the obvious excitement of being able to generate truly de novo proteins, the results are a further testament to the ability of Basecamp Research’s dataset to produce better results compared to publicly available datasets, which barely scratch the surface of the Earth’s immense biodiversity,” added Dr. Glen Gowers, co-founder of Basecamp Research. “Earlier we were able to show that our BaseFold model, also powered by our dataset, outperformed AlphaFold2 in predicting protein structures. Generative AI is going to have a huge impact across biotech, and we’re dedicated to collecting the data and tools needed to make its potential a reality.”
The full preprint can be found here: https://www.biorxiv.org/content/10.1101/2024.05.03.592223v1
Basecamp Research invites the research community to try ZymCTRL and has released it for public use on Hugging Face: https://huggingface.co/AI4PD/ZymCTRL
For media and other inquiries, please contact [email protected], +44 07867 488769
About Basecamp Research
Basecamp Research is a leader in mapping biodiversity for AI-based design of biological systems. We match and refine novel proteins for our partners’ exact industrial, therapeutic or diagnostic applications using BaseGraph™, a new generation of AI design that is powered by the first-ever high-resolution map of global genetic biodiversity. 
Understanding the full genetic, evolutionary, and environmental context of each protein allows Basecamp Research to design tailored proteins for specific applications without the need for expensive and time-consuming directed evolution campaigns. We’re a team of explorers, scientists and policy experts driven by our ambition to protect and learn from nature’s diversity, whilst delivering life-changing breakthroughs to those who need them most. 
For more information, visit www.basecamp-research.com.
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Artificial Intelligence

InterSystems TrakCare and InterSystems IRIS for Health to underpin deployment of fully unified future-ready AI-driven healthcare ecosystem at NEOM

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RIYADH, Saudi Arabia, July 24, 2024 /PRNewswire/ — InterSystems, a creative data technology provider dedicated to helping customers solve their most critical scalability, interoperability, and speed challenges, and NEOM, the sustainable development taking shape in northwest Saudi Arabia, today announced a groundbreaking partnership to revolutionize the healthcare experience within NEOM.

The partnership enables NEOM to deploy InterSystems TrakCare® across its healthcare facilities, which currently include one hospital and 41 clinics. TrakCare is a unified health information system that provides clinical, administrative, and financial information as a single source of truth for each patient and offers enhanced clinical decision support capabilities.
Additionally, by the end of 2024 InterSystems IRIS® for Health will centralize NEOM’s clinical application data to facilitate the development of innovative health programs. InterSystems IRIS for Health is a comprehensive, cloud-first digital health development platform that provides all the building blocks needed for Machine Learning and to work with practically any healthcare data standard, including HL7® FHIR®.
By adding IRIS for Health to their health ecosystem NEOM will significantly enhance the overall individual’s experience and move towards realizing NEOM’s ‘one patient, one record’ approach.
As a flexible and powerful healthcare information system TrakCare equips NEOM with extensive data capabilities, and as a digital health development platform IRIS for Health facilitates NEOM’s use of Artificial Intelligence (AI) driven technology. Combining these offerings empowers healthcare providers to make better informed decisions that optimize operations effectively for world-class healthcare services.
“This partnership marks a significant milestone in our mission to advance healthcare through innovative technology,” said Ali Abi Raad, Country Manager for the Middle East, India, and South Africa, InterSystems. “We are proud to support NEOM and their vision of building a digitally integrated healthcare ecosystem and becoming a global leader in health and well-being.”
“The partnership with InterSystems is a significant milestone in realizing our digital first and personalized prevention focused healthcare system. To realize this vision, we need flexible and data standards driven technology partners who are committed to our ‘one patient, one record’ approach.” – Dr Mahmoud Alyamany, Sector Head, NEOM Health & Wellbeing.
About InterSystems
Established in 1978, InterSystems is the leading provider of next-generation solutions for enterprise digital transformations in the healthcare, finance, manufacturing, and supply chain sectors. Its cloud-first data platforms solve interoperability, speed, and scalability problems for large organizations around the globe. InterSystems is committed to excellence through its award-winning, 24×7 support for customers and partners in more than 80 countries. Privately held and headquartered in Cambridge, Massachusetts, InterSystems has 39 offices in 28 countries worldwide. For more information, please visit InterSystems.com.
About NEOM
NEOM is an accelerator of human progress and a vision of what a new future might look like. It is a region in northwest Saudi Arabia on the Red Sea being built from the ground up as a living laboratory – a place where entrepreneurship will chart the course for this new future. It will be a destination and a home for people who dream big and want to be part of building a new model for exceptional livability, creating thriving businesses and reinventing environmental conservation.
NEOM will include hyperconnected, cognitive cities, ports and enterprise zones, research centers, sports and entertainment venues and tourist destinations. As a hub for innovation, entrepreneurs, business leaders and companies will come to research, incubate, and commercialize new technologies and enterprises in groundbreaking ways. Residents of NEOM will embody an international ethos and embrace a culture of exploration, risk-taking and diversity.
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Artificial Intelligence

Zesty Introduces Cloud Insights and Automation Platform To Ensure Optimization and Cloud Operational Excellence

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With prescriptive insights and AI automation for cloud infrastructure management for multiple CSPs, Zesty’s platform makes it simple to optimize cloud spending and performance, improve utilization rates, and create new opportunities for FinOps and DevOps teams
SAN MATEO, Calif., July 24, 2024 /PRNewswire/ — Zesty, a leader in automated cloud infrastructure management, announced today the launch of its Insights and Automation Platform. Designed to support a multi-cloud strategy and transform cloud challenges into opportunities for FinOps and DevOps teams, the platform optimizes cloud spending and improves utilization rates with prescriptive insights and automation, empowering companies to focus on innovation, not cloud or budget management.

As global innovation drives continuous exponential cloud growth, more than half of CIOs have reported an increase in their IT budget for this year specifically to enhance their capacity for financing new projects. Overseeing multiple vendors, intricate cost structures, and ever-evolving company needs have created enormous complications for companies as they scale and budget. While R&D teams prioritize leveraging cloud services to drive innovation and competitive advantage, Finance teams focus on controlling costs and ensuring budget adherence.
Zesty’s platform incorporates new insights to drastically simplify SMB and enterprise cloud cost management by prioritizing the highest value recommendations for FinOps teams. For example, the recommendations focused on reducing unused resources alone can help companies cut costs by 7%, which in some cases represents millions of dollars annually. The platform also hosts Zesty’s AI-driven flagship solutions, Commitment Manager and Zesty Disk, which automatically scale cloud resources up and down and identify potential savings across services. Zesty’s integration of insights and automation ensures that cloud investments consistently align with evolving business objectives with even greater efficiency and savings.
“CIOs are constantly exploring avenues to finance new projects. The Zesty Insights and Automation Platform will play a pivotal role in identifying areas of waste and help to free those funds for innovative projects. Machine learning capabilities and predictive analytics are driving serious returns for FinOps teams, with some of our customers recovering over a million dollars a year from cloud waste and using that to amplify innovation,” said Maxim Melamedov, CEO and Co-Founder of Zesty. “Our mission is to help businesses easily eliminate cloud-related waste in all its forms, financial, cloud resources, environmental, and time. Our platform comes at a critical time given the industry’s urgent need for effective financial management of cloud operations. Companies across all industries are desperate for a guide on their FinOps journey, and we are excited to be able to help.”
Zesty sets a new standard for the fragmented FinOps industry, providing a unified and efficient approach to cloud management, transforming visibility into action with prescriptive insights and automation, optimizing services such as AWS’ EC2, EBS, RDS, S3, ELB, EIP, and Azure’s Virtual Machines. Fueling its commitment to enhancing cloud infrastructure efficiency, Zesty manages billions in AWS contracts. Zesty’s customer-centric approach earned the company a near-perfect (4.9/5) CSAT (Customer Satisfaction Score) in 2023.
To learn more about Zesty’s Insights and Automation Platform or to book a demo, click here.
About Zesty
Zesty helps organizations accelerate innovation with its cloud infrastructure optimization platform. Powered by machine learning, Zesty provides FinOps and DevOps teams with prescriptive insights and automation to achieve the ideal utilization of cloud resources and enables CIOs to balance operational excellence and costs. Zesty’s optimization platform helps companies efficiently allocate resources for applications, with solutions for compute, storage, containers, databases, and more, saving time and money.
Founded in 2019, Zesty was built with the vision of making the cloud more affordable and accessible while reducing waste. With offices in San Mateo, Tel Aviv, Kiev, New York, and London, Zesty supports thousands of organizations, helping them get maximum value out of their cloud infrastructure. To learn more, visit https://zesty.co/.
Media Contact Kate Schoenstadt [email protected] IL: +972(0)-54-7776684
 

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Artificial Intelligence

Zenoo calls for collaboration to tackle AI fraud in banking

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CAMBRIDGE, England, July 24, 2024 /PRNewswire/ — UK technology company Zenoo warns the use of AI in banking fraud is just getting started – and collaboration with AI specialists is required to stem its flow.

Cambridge-based Zenoo – whose clients include London Stock Exchange, Experian, Transunion and NASA – supplies digital onboarding and protection from financial crime for businesses and has issued a warning to the banking community that the malevolent use of AI will only become more sophisticated and prevalent in the future.
Zenoo UK managing director George Taylor said: “It’s an enormous concern how quickly and significantly AI is being innovated to assist in banking fraud. In particular, social engineering attacks to steal personal information, enable identity theft and unauthorised access to bank accounts, is becoming remarkably advanced.”
Key areas of concern include Psychographic Profiling – where AI will analyse extensive data to create detailed psychographic profiles of individuals, tailoring social engineering attacks to exploit specific psychological traits – and Manipulative Interactions where the rising use of chatbots and virtual assistants in banking will be taken advantage of to engage in prolonged, convincing interactions with targets to extract sensitive information or induce them to perform actions that compromise their security.
Taylor is calling for banking to respond to the AI threat with AI too by collaborating with AI defence systems that can learn and adapt in real-time to detect and respond to emerging threats and machine learning models to identify and predict potential fraud based on evolving patterns and behaviours.
He adds: “The key word in combatting the AI threat is ‘collaboration’. Here at Zenoo we partner with cutting edge providers of the latest AI deepfake detection solutions which can be easily integrated into existing or new customer on boarding flows to combat fraud. We must take advantage of those specialists who are analysing and responding to the AI threat on a daily basis”.
Visit Zenoo to learn more or book a demo.
About Zenoo
Zenoo specialises in the remote onboarding of customers for international companies to help them improve their conversion rates, breaking down barriers and making it easier for their customers to open accounts online. Visit partner.zenoo.com for further information. 
Media enquiriesContact Bruce Ackland on +44 7884 076548 or email [email protected] 

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