Artificial Intelligence
BioXcel Therapeutics Announces First Patient Enrolled in Phase 1b/2 Study of BXCL501 for Acute Treatment of Agitation Associated with Dementia
Foundational study with plans to address multiple types of agitation associated with dementia
Expands the potential therapeutic use of BXCL501 beyond neuropsychiatric disorders
Topline results expected in mid-2020
NEW HAVEN, Conn., Jan. 07, 2020 (GLOBE NEWSWIRE) — BioXcel Therapeutics (“BTI” or “Company”) (Nasdaq: BTAI), a clinical-stage biopharmaceutical company utilizing artificial intelligence approaches to identify and advance the next wave of medicines in neuroscience and immuno-oncology, today announced that the first patient has been enrolled in a Phase 1b/2 study of BXCL501, the Company’s proprietary sublingual thin-film formulation of dexmedetomidine (“Dex”), for the acute treatment of agitation in patients with dementia.
“We are excited to advance the clinical development of BXCL501 in agitation associated with dementia, a third potential indication for our lead product candidate,” commented Robert Risinger, M.D., Vice President, Clinical Development of BTAI. “With no approved treatments, there is a significant need for better treatment options for the 6 million patients in the U.S. with dementia, many of whom will experience agitation during the course of their disease. We believe our candidate, BXCL501, with its unique mechanism and convenient oral dosing, has the potential to rapidly reduce agitation associated with dementia without excessive sedation or other undesired side effects. This study builds upon the foundation for a broad BXCL501 program in dementia, including the treatment of chronic agitation and the prevention of agitation using a wearable device in combination with BXCL501.” The multicenter, randomized, double-blind, placebo-controlled, ascending dose Phase 1b/2 study is designed to evaluate the efficacy, pharmacokinetics, safety and tolerability of BXCL501 in adults 65 years and older who exhibit acute agitation associated with all forms of dementia, including Alzheimer’s disease. The dementia program expands on the Phase 1b study performed with BXCL501 in 135 patients with agitation associated with schizophrenia, and also builds on the positive results observed in reducing agitation with intravenous Dex in Alzheimer’s disease patients. This is an adaptive design and is expected to assess multiple dose cohorts of BXCL501 or matching placebos. Following the completion of each dose cohort, a safety and tolerability review is expected to be performed to determine the next tested dose. The study is designed to assess agitation as measured by the Pittsburgh Agitation Scale, a validated clinical instrument, as well as improvement in the modified Cohen Mansfield Agitation Inventory and Positive and Negative Syndrome Scale, Excitatory Component (“PEC”).
About BXCL501
BXCL501 is a potential first-in-class, proprietary sublingual thin film of dexmedetomidine, a selective alpha-2a receptor agonist for the treatment of acute agitation. BTI believes that BXCL501 directly targets a causal agitation mechanism and the Company has observed anti-agitation effects in multiple clinical studies across multiple neuropsychiatric indications. BXCL501 has also been granted Fast Track Designation by the U.S. Food and Drug Administration for the acute treatment of agitation.
A Phase 1b safety and efficacy study of BXCL501 yielded positive dose-response data. BXCL501 is being evaluated in the SERENITY program, consisting of two Phase 3 studies for the acute treatment of agitation in patients with schizophrenia (SERENITY I) and bipolar disorder (SERENITY II). BXCL501 is also being evaluated in a Phase 1b/2 trial for the treatment of agitation associated with dementia.
About Agitation Associated with Dementia About BioXcel Therapeutics, Inc. Forward-Looking Statements These and other important factors could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent management’s estimates as of the date of this press release. While BTI may elect to update such forward-looking statements at some point in the future, except as required by law, it disclaims any obligation to do so, even if subsequent events cause our views to change. These forward-looking statements should not be relied upon as representing BTI’s views as of any date subsequent to the date of this press release.
BioXcel Therapeutics, Inc. Investor Relations: Media: Source: BioXcel Therapeutics, Inc.
Dementia is a neurocognitive condition caused by damage to brain cells that leads to a decline in cognitive abilities and independent function. It affects approximately 6 million individuals in the United States, with Alzheimer’s disease accounting for 60-70% of these cases. During the course of the disease, patients with dementia often suffer from psychological and behavioral symptoms, such as agitation, which has been reported in up to 70% of patients. Agitation associated with dementia can negatively affect both the patient and caregiver’s quality of life. Caregiver burden can contribute significantly to burnout, which can result in premature institutionalization of the patient. Treating agitation associated with dementia has been a challenge for providers and current standards of care often have a slow onset of action and/or cause excessive sedation. There are currently no FDA-approved therapies for the treatment of dementia-related agitation, and off-label therapies have black box warnings associated with their use.
BioXcel Therapeutics, Inc. is a clinical stage biopharmaceutical company utilizing artificial intelligence to identify improved therapies in neuroscience and immuno-oncology. BTI’s drug re-innovation approach leverages existing approved drugs and/or clinically validated product candidates together with big data and proprietary machine learning algorithms to identify new therapeutic indices. BTI’s two most advanced clinical development programs are BXCL501, a sublingual thin film formulation designed for acute treatment of agitation resulting from neuropsychiatric disorders, and BXCL701, an orally administered systemic innate immunity activator designed for treatment of a rare form of prostate cancer, pancreatic cancer and advanced solid cancers in combination with other immuno-oncology agents. For more information, please visit http://www.bioxceltherapeutics.com/.
This press release includes “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements in this press release include but are not limited to the timing and data from clinical development initiatives and trials for BXCL501. When used herein, words including “anticipate,” “being,” “will,” “plan,” “may,” “continue,” and similar expressions are intended to identify forward-looking statements. In addition, any statements or information that refer to expectations, beliefs, plans, projections, objectives, performance or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking. All forward-looking statements are based upon BTI’s current expectations and various assumptions. BTI believes there is a reasonable basis for its expectations and beliefs, but they are inherently uncertain. BTI may not realize its expectations, and its beliefs may not prove correct. Actual results could differ materially from those described or implied by such forward-looking statements as a result of various important factors, including, without limitation, its limited operating history; its incurrence of significant losses; its need for substantial additional funding and ability to raise capital when needed; its limited experience in drug discovery and drug development; its dependence on the success and commercialization of BXCL501 and BXCL701 and other product candidates; the failure of preliminary data from its clinical studies to predict final study results; failure of its early clinical studies or preclinical studies to predict future clinical studies; its ability to receive regulatory approval for its product candidates; its ability to enroll patients in its clinical trials; its approach to the discovery and development of product candidates based on EvolverAI is novel and unproven; its exposure to patent infringement lawsuits; its ability to comply with the extensive regulations applicable to it; its ability to commercialize its product candidates; and the other important factors discussed under the caption “Risk Factors” in its Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2019, as such factors may be updated from time to time in its other filings with the SEC, which are accessible on the SEC’s website at www.sec.gov.
www.bioxceltherapeutics.com
John Graziano
[email protected]
1.646.378.2942
Julia Deutsch
[email protected]
1.646.378.2967
Artificial Intelligence
Data Center Security and Spending Skyrocket Amid AI Boom
USA News Group Commentary Issued on behalf of Avant Technologies Inc.
VANCOUVER, May 31, 2024 /PRNewswire/ — USA News Group – With the artificial intelligence (AI) revolution fully underway, the importance and security of the data centers that power the new technology is surging. The role and preservation of these data centers is generating multiple calls for them and their power sources to be recognized as a matter of national security. Former Google CEO Eric Schmidt went so far as to predict that AI data centers will one day be “on military bases surrounded by machine guns,” as stated in an interview with Noema Magazine. According to analysts at Dell’Oro Group, data center spending is forecast to grow at an astounding 18% CAGR over the next 5 years. Behind the scenes, tech companies are working tirelessly to provide new developments that will make this transition go smoother, including from Avant Technologies Inc. (OTCQB: AVAI), Equinix, Inc. (NASDAQ: EQIX), Vertiv Holdings Co (NYSE: VRT), Iron Mountain Incorporated (NYSE: IRM), and Snowflake Inc. (NYSE: SNOW).
At the forefront of generative AI innovation, Avant Technologies Inc. (OTCQB: AVAI) has been perfecting its flagship product, Avant AITM. The cutting-edge AI system is praised for its machine and deep learning capabilities, making it suitable for a wide range of industries and applications. To explore future possibilities for its AI data center cloud infrastructure, Avant recently engaged Wired4Tech, a highly regarded AI infrastructure consulting firm.
“We are excited to engage Wired4Tech to benchmark the performance of an innovative, next-generation AI server,” said William Hisey, CEO of Avant Technologies. “By conducting rigorous benchmark testing of this promising server technology, we expect to validate its expected performance and cost-saving benefits.”
As part of the new agreement, Wired4Tech will carry out detailed performance benchmarking for Avant. This will include evaluating key metrics such as response time, throughput, CPU and memory usage, disk I/O, network latency, and error rates. A special focus will be placed on response time, analyzing how quickly the server responds to different actions to provide insights into its overall responsiveness.
Avant considers these metrics to be critical for evaluating the server’s ability to handle complex AI tasks both effectively and dependably. Furthermore, Wired4Tech will examine the server’s power usage and identify possible cost-saving opportunities.
Prior to this update, Avant Technologies revealed a bold initiative to create groundbreaking, proprietary AI software aimed at improving its next-generation data centers. Additionally, the company intends to implement AI-driven Zero Trust Architecture (ZTA) throughout its data center operations. The AvantAI™ platform has also been upgraded to feature intelligent, proactive monitoring and management capabilities for data centers.
Digital infrastructure company Equinix, Inc. (NASDAQ: EQIX) recently announced the availability of Dell PowerStore on its Equinix Metal, a new, enterprise-grade Storage as a Service (STaaS) solution. The new availability enables enterprises to unlock multicloud strategies with enhanced performance, security and control, by marrying Equinix’s cloud adjacency and Dell’s leading storage solutions.
“Businesses need storage solutions that allow them to be more agile and get the most out of their hybrid multicloud architectures,” said Merrie Williamson, Chief Customer and Revenue Officer at Equinix. “By combining the powerful capabilities of Dell PowerStore with Equinix’s global platform, we are giving them the low-latency, high-performance connectivity they require without sacrificing on security or breaking their budget.”
The Dell PowerStore on Equinix Metal service offers businesses an easy way to manage and deploy their storage, computing, and networking needs worldwide. This service helps reduce the complexity and costs of running IT operations. It’s a dedicated storage solution designed for environments close to the cloud, giving customers quick, secure, and scalable access to public cloud providers through Equinix’s numerous data centers. This means businesses can efficiently connect to the cloud and manage their infrastructure with less hassle.
Ahead of this year’s Datacloud Global Congress 2024 where its CEO Giordano Albertazzi is set to join a keynote panel, Vertiv Holdings Co (NYSE: VRT) launched its new AI hub, featuring the industry’s first AI reference design portfolio for critical digital infrastructure.
The new Vertiv AI Hub offers a variety of helpful resources like white papers, industry research, and tools. It also includes information on power and cooling solutions for both new and existing facilities. Their new design library showcases flexible cooling and power systems that can handle both current and future computer chip needs, supporting anywhere from 10 to 140 kilowatts per rack.
“We are committed to providing deep knowledge, the broadest portfolio, and expert guidance to enable our customers to be among the first to deploy energy-efficient AI power and cooling infrastructure for current and future deployments,” said Albertazzi. “Our close partnerships with leading chipmakers and innovative data center operators make us uniquely qualified to help our customers and partners on their AI journey.”
Known for being a top company in storing paper documents and backup tapes, Iron Mountain Incorporated (NYSE: IRM) is expanding its data center network by opening a new data center in Toronto, Canada. The new facility is designed to support growth in its online backup services, Connected Backup and LiveVault, which provide automated backups for desktop PCs and specializes in server backups, respectively.
“In addition to opening the data center in Canada, Iron Mountain Digital is actively broadening its global data center presence and in the process of opening a series of data centers outside of the U.S. and Canada, to better support our customers wherever they do business,” said John Clancy, president of Iron Mountain Digital, the technology arm of Iron Mountain. “We’ve had a growing demand from our customers worldwide for data protection solutions and services.”
AI Data Cloud company Snowflake Inc. (NYSE: SNOW) recently released its financial results for Q1 2025, which included a 33% year-over-year growth in revenue, and a net revenue retention rate of 128%. The growth numbers came shortly ahead of Snowflake CEO Sridhar Ramaswamy’s scheduled fireside chat at the company’s 6th annual Snowflake Data Cloud Summit 2024 alongside NVIDIA Founder and CEO Jensen Huang.
“We finished our first quarter with strong performance across many of our key metrics,” said Ramaswamy in the Q1 2025 financials report. “Product revenue was up 34% year-over-year at nearly $790 million, while remaining performance obligations were $5.0 billion, up 46% year-over-year. Our core business is very strong. Our AI products, now generally available, are generating strong customer interest.”
As of the financial results release, Snowflake has 485 customers with trailing 12-month product revenue greater than $1 million, and 709 Forbes Global 2000 customers. Snowflake also announced its intent to acquire certain technology assets and hire key employees from TruEra, an AI observability platform. TruEra provides capabilities to evaluate and monitor large language model (LLM) applications and machine learning models in production.
Source: https://usanewsgroup.com/2023/10/26/unlocking-the-trillion-dollar-ai-market-what-investors-need-to-know/
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View original content:https://www.prnewswire.co.uk/news-releases/data-center-security-and-spending-skyrocket-amid-ai-boom-302160707.html
Artificial Intelligence
GIGABYTE AI New Era: Humanity X Art X Technology Exhibition
Embrace the Future with Computing Power! GIGABYTE AI PCs Lead You to Explore New Frontiers
TAIPEI, May 31, 2024 /PRNewswire/ — GIGABYTE is excited to present the “AI New Era” exhibition, showcasing how AI is transforming our world. This event explores AI-generated art, AI applications, and other immersive experiences that demonstrate the practical uses of AI PCs in everyday life.
Exhibition Themes
The “GIGABYTE AI New Era” exhibition features three thematic areas, each illustrating the diverse nature of AI:
AI Art: This area showcases dynamic images and interactive art created by international artists. Notable contributors include the Dimension + new media art team led by Escher Tsai (Taiwan) and Keith Lam (Hong Kong), Ygor Marotta from the VJ Suave studio in São Paulo, Brazil, and emerging Taiwanese artist Tim Wei. Attendees will embark on a sensory journey as these artists share their inner worlds and the collaborative process of integrating GIGABYTE AI PCs into their work. VS AI Street Battle: In collaboration with Hello World, this section challenges traditional art forms using the latest text-to-image AI applications. Utilizing GIGABYTE AI PCs’ powerful and stable computing capabilities, this area combines large-scale arcade fighting games with generative AI, creating a unique and creative battle system. AI Applications Featuring RTX -AI PCs: This area explores how AI enhances everyday life across various fields, including gaming, digital art, content creation, image processing, and productivity. Guided by GIGABYTE AI PCs, consumers can experience limitless AI applications, seamlessly integrating AI into their daily routines. Emmy-nominated filmmaker Hugh Hou (US) will curate the AI Use Case zone, showcasing the latest AI technology and providing a professional workflow for creating immersive videos. Additionally, GIGABYTE will collaborate with NVIDIA to showcase a series of advanced AI applications featuring GeForce RTX graphics cards.Invitation to All
GIGABYTE warmly welcomes technology enthusiasts and art connoisseurs to join this grand event and experience the revolution in technology and art brought by artificial intelligence. For more information about the event, please visit the official website: GIGABYTE AI 2024.
Join us in exploring the future of AI and its impact on our daily lives, and witness how GIGABYTE is leading the charge in integrating AI into the world of art and technology.
Photo – https://mma.prnewswire.com/media/2426946/GIGABYTE.jpg
View original content:https://www.prnewswire.co.uk/news-releases/gigabyte-ai-new-era-humanity-x-art-x-technology-exhibition-302160686.html
Artificial Intelligence
Portkey Announces Integration of Zero-Knowledge Proofs for Enhanced Identity Management and Security
SINGAPORE, May 31, 2024 /PRNewswire/ — Portkey, the innovative account abstraction wallet on the aelf blockchain, proudly announces its latest initiative to enhance user security and privacy through the integration of Zero-Knowledge Proofs (ZKPs). This cryptographic technique allows one party (the prover) to prove to another party (the verifier) that a particular statement is true without revealing any additional information, ensuring unparalleled privacy and security for Portkey’s users.
The integration of Zero-Knowledge Proofs (ZKPs) in Portkey’s Web3 wallet and decentralised identity management system promises to offer blockchain users unprecedented levels of provable and tamper-proof identity verification. Portkey will enable users to securely prove their eligibility and compliance with service providers’ requirements without disclosing sensitive personal information. By ensuring digital personas are both distinct and verifiable, Portkey’s adoption of ZKPs aims to bridge the gap between Web2 and Web3 applications, fostering a more secure, privacy-centric, and user-focused internet.
As the prevalence of digital transactions and online interactions increases, it has become even more imperative to protect user data. Portkey’s upcoming integration of ZKPs significantly strengthens its security framework, ensuring that sensitive user information remains confidential and secure. This allows users to engage with digital services confidently, knowing their data is safeguarded by the highest standards of cryptographic security. Portkey’s commitment to privacy and security is a cornerstone of its mission, aimed at establishing a safe and trustworthy digital environment for users navigating the complexities of this increasingly interconnected world.
Introducing SocialLogin
Portkey intends to operate ZKPs through SocialLogin, which encompasses a two-step process: proof generation and verification, for secure transaction validation. In the proof generation phase, the prover creates a proof that confirms the validity of a statement using advanced cryptographic methods. During verification, this proof is evaluated by a verifier who, if the proof is valid, accepts the statement as true without accessing any underlying data. This integration will grant developers the capability to allow users to authenticate themselves on their preferred dApps through their pre-existing social accounts on platforms like Google, Facebook, Twitch, and various other third-party providers.
At the application level, users register with Portkey by logging in with Google credentials and receive an identity token (JWT). This token is sent to the Proving Service, which generates a zk-SNARK proof. The proof is then used to sign transactions on aelf blockchain, where it is verified on-chain. If the proof is valid, the transaction is executed, ensuring enhanced security and privacy for users. At the protocol level, this involves creating a new interface to generate proofs, developing verification functions, and converting proof-based transactions to normal ones while ensuring robust error handling and testing.
This technological advancement for Portkey is critical for enhancing users’ security and privacy as it eliminates the dependence on external verifier services, and solidifies its position as a pioneering force in the realm of digital wallets and decentralised identity management. SocialLogin is currently being developed and intergrated swiftly on Portkey. Soon, users will be able to experience the smooth login and registration process.
Stay updated on Portkey’s news and engage with the Portkey community on:Website: https://portkey.finance X: https://x.com/Portkey_DID Telegram: https://t.me/Portkey_Official_Group Discord: https://discord.gg/zSBDUV9q
About Portkey
Portkey aims to be the most useful Web2-to-3 Wallet: it targets Web2 projects and provides them with simple, seamless, and scalable access to a complete Web3 ecosystem. While Portkey serves as an Account Abstraction Wallet with intuitive social recovery features, it also promotes Decentralised Identity Technology, enabling Web2 businesses and developers to migrate seamlessly into Web3. It also features aelf’s unique Virtual Address (VA) technical approach, which is cheaper, faster and easier to implement compared to other industry standards.
View original content:https://www.prnewswire.co.uk/news-releases/portkey-announces-integration-of-zero-knowledge-proofs-for-enhanced-identity-management-and-security-302160594.html
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