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Brookhaven Lab Mobilizes Resources in Fight Against COVID-19

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UPTON, NY, April 17, 2020 (GLOBE NEWSWIRE) — Scientists and staff at the U.S. Department of Energy’s (DOE) national laboratories are marshalling their expertise, unique facilities, and other key resources in the battle against COVID-19. At Brookhaven National Laboratory:• Research is already underway to better understand key characteristics of the virus that causes COVID-19 and its interactions with human cells, which could help guide the development of therapeutic drugs and vaccines.• Laboratory scientists and collaborators are using experiments and computational methods to identify the most promising drug/vaccine candidates, and developing tools to help other scientists keep up with the latest developments around the world.• The Laboratory has also gathered critical protective equipment as part of a Federal effort to support medical professionals, and is exploring options for making much-needed supplies.“Brookhaven Lab has exceptional resources for addressing some of the most urgent scientific and logistical challenges of this pandemic,” said John Hill, director of Brookhaven Lab’s National Synchrotron Light Source II (NSLS-II), who is chairing a working group to coordinate the Lab’s COVID-19 science and technology efforts, and is serving on a team coordinating the COVID-19 research across all the DOE national labs.“The speed with which the entire scientific community is attacking this problem is amazing,” he said, “and the whole Lab, whether working off site or on, is part of this effort.”Deciphering protein structuresEven as the Laboratory operates with minimal staff to help keep the virus from spreading, experiments are running at two of NSLS-II’s protein crystallography beamlines to help find ways to thwart the virus. These experiments aim to characterize the atomic-level structure of viral components, including how they connect with receptors on human cells, so scientists can identify ways to block the infection-causing interactions.NSLS-II, a DOE Office of Science user facility, provides x-ray beams to create those atomic-scale pictures.“NSLS-II has the brightest synchrotron x-rays in the world for studying the proteins in the virus and understanding better the processes hijacked in infected cells,” said Sean McSweeney, leader of Brookhaven Lab’s structural biology program. “The high brightness means we can get ‘pictures’ from tiny crystal samples of the proteins. We don’t need to spend weeks, or months, growing big crystals, which is typically a bottleneck in protein crystallography. We also have methods for testing potential drugs that bind to these proteins and then collecting and sifting through data very rapidly—all of which greatly speed the process of discovery.”Scientists from several pharmaceutical companies and academic researchers have already collected data, and more are expected each week, in some cases collaborating in the search for antiviral agents and targets for vaccines. Brookhaven scientists are engaged in this work as well.“One group, which includes scientists from the biology department, is working to solve the structure of an ‘envelope’ protein embedded in the virus’s membrane. This protein is important to the virus’s life cycle,” McSweeney said. “Deciphering these structures will provide atomic-level data that could guide the development of drugs that bind to the proteins and interfere with their functions so the virus can no longer infect cells or replicate.”The structural studies may help identify viral components that are most likely to trigger the production of antibodies—chemicals produced by the immune system that can fight off an infection. These immune-system-triggering proteins, known as antigens, form the basis of most vaccines.“The Department of Energy has been exceptionally helpful in fast-tracking the approval process for this research,” Hill said. “Every proposal is getting beamtime.”Much of the data will be published in the open research literature and deposited in the globally accessible Protein Data Bank so that scientists everywhere can learn from one another and build on each other’s efforts.  Brookhaven is also hosting a centralized portal to streamline access to all the structural biology resources across the DOE complex.Brookhaven is also fielding requests to pursue COVID-19 protein studies at its new cryo-electron microscopy (cryoEM) facility—the Laboratory of BioMolecular Structure—which is currently under construction adjacent to NSLS-II.“The Laboratory and DOE both recognize how crucial this facility will be to advancing our understanding of COVID-19, particularly for studying the large protein complexes that span cell membranes,” said Hill. “We are so grateful to everyone who is working to bring this facility into operation at an accelerated pace.”Computational approachesOnce scientists know the viral components they want to target for developing therapeutic agents, they need to know which small drug-like molecules will fit into the viral-protein pockets or the cell-surface receptors to which the virus binds. Brookhaven scientists are working on that piece of the puzzle, too.NSLS-II, for example, can run experiments using samples of viral or receptor proteins and drug candidates together to find which fit best and offer the most promise of blocking infection.But the universe of small molecules that could interact with protein components is extremely large. Running experiments to look at every possibility would take far too long.Fortunately, computational scientists at Brookhaven, working in partnership with colleagues at Stony Brook University, Argonne National Laboratory (ANL), Rutgers University, Oak Ridge National Laboratory (ORNL), the University of Texas, and elsewhere—currently around 160 scientists, 25 at Brookhaven—are helping to speed up the search for drugs.“The aim of this research is to accelerate the development of antiviral drugs by modeling proteins that play critical roles in the virus life cycle to identify promising drug targets,” said Kerstin Kleese van Dam, director of Brookhaven Lab’s Computational Science Initiative (CSI).Using supercomputing resources across the U.S., the scientists will screen the chemical structures of a wide range of small molecules that might be able to block key viral functions. These “virtual” experiments will explore the chemical structures of known drugs that are already licensed and could quickly be repurposed, as well as libraries of small drug-like molecules that could be developed into drugs. Brookhaven scientists are focused on large-scale libraries with billions of chemical structures that could be manufactured quickly for testing.  This research relies on machine learning and other tools of artificial intelligence (AI) running simulations of the interactions between proteins and potential drugs. The virtual screening using these “molecular dynamics” simulations will refine the machine learning and AI approaches so that successive rounds of evaluations create a list of potentially viable small-molecule drug candidates.
As one local example, in a project led by Stony Brook, Lab scientists will be running simulations to see which molecules might block the interaction between the “crown” (or corona) of “spike” proteins on the COVID-19 virus and receptors on human lung cells.“In a first step, we will be looking at 60 different target sites where a new drug may attach to the virus and one billion drug-like molecules to identify the most promising options for neutralizing the virus to keep it from entering cells,” Kleese van Dam said. Then, only those particularly promising molecules would need to be studied in detail with structural studies at synchrotrons like NSLS-II or cryo-EM facilities.Kleese van Dam put out a call for volunteers across the Lab who have experience with high performance computing and the Lab’s computing clusters to help make faster progress, saying “We have the data, we have the tools, but need people who can help us to run the programs and check that they ran correctly, and to test an initial set of structures against possible drug targets.”
The response was overwhelming. “We had very quickly a large number of volunteers—more than we could accommodate on our current project—from all across the Lab, including staff from NSLS-II, the Center for Functional Nanomaterials (CFN), high-energy and nuclear physics, and the Collider-Accelerator Department,” Kleese van Dam said.Many scientists at the Lab’s Office of Science user facilities—which include CFN and the Relativistic Heavy Ion Collider (RHIC) in addition to NSLS-II—have experience dealing with “big data” problems, so this call-to-action was a perfect fit.“I’m so grateful to those who stepped up so selflessly,” Kleese van Dam said. “We’re compiling a list of all these volunteers so we can deploy them to a range of COVID-19 projects as needed going forward.”Kleese van Dam’s group is also developing computational tools to help scientists battling COVID-19 keep up with the latest research developments around the world.“More than 15,000 new papers related to COVID-19 have been published since the start of the outbreak in December 2019, and the quality and relevance of these papers to current research needs varies dramatically,” she said. “We’re developing a ‘natural language processing’ program that will search through a library of all these papers to pull out the most relevant information based on a researcher’s plain-language question.” Using this system, scientists would be able to more easily find and track the latest data on which drugs are in clinical trials, for example, or pull out research on the latest potential targets.A different kind of computational model developed with help from Brookhaven scientists was designed to simulate the spread of the virus in the Chicago area. This project was led by Sergei Maslov, a former Brookhaven scientist who is now at the University of Illinois at Urbana Champaign and is still a CFN user, with help from CFN’s Alexei Tkachenko. Government officials in Illinois used this model in an early effort to optimize their response to the outbreak there, and ongoing research continues to improve and extend this work.On the front linesIn addition to attacking the COVID-19 research head-on, the Laboratory has been working with the DOE to gather and distribute the Lab’s excess personal protective equipment (PPE) to health care workers on the front lines. Hill’s COVID-19 science and technology working group is also exploring other ways the Lab can contribute at the local hospital level.“We looked at ways we might sterilize masks or other critical equipment,” Hill said, “and we’re exploring options for using the Lab’s 3-D printers to make components for face shields, or possibly even ventilators. But there are lots of complicated details still to be worked out.”Meanwhile, Battelle—which manages Brookhaven Lab as one entity of Brookhaven Science Associates (the other half being Stony Brook University)—is hoping to meet the sterilization need. They’ve deployed a shipping container outfitted with a Critical Care Decontamination System to Stony Brook Hospital. According to Battelle, the system uses hydrogen peroxide vapor to clean tens of thousands of pieces of PPE at a time.“This system could be a real game changer to keep healthcare workers protected as they meet the rising influx of COVID-19 patients,” Hill said.Check the Lab’s COVID-19 research page to learn more about the projects being coordinated by the COVID-19 S&T Working Group.Operations at NSLS-II, CFN, and the CSI are supported by the DOE Office of Science. The AMX and FMX beamlines carrying out protein crystallography at NSLS-II are also supported by the National Institutes of Health; CSI receives additional support through Brookhaven’s Program Development funds.***Brookhaven National Laboratory is supported by the U.S. Department of Energy’s Office of Science. The Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time. For more information, visit https://www.energy.gov/science/ [https://www.energy.gov/science/]
Follow @BrookhavenLab on Twitter [http://twitter.com/BrookhavenLab] or find us on Facebook [http://www.facebook.com/BrookhavenLab/]One of ten national laboratories overseen and primarily funded by the Office of Science of the U.S. Department of Energy (DOE), Brookhaven National Laboratory conducts research in the physical, biomedical, and environmental sciences, as well as in energy technologies and national security. Brookhaven Lab also builds and operates major scientific facilities available to university, industry and government researchers. Brookhaven is operated and managed for DOE’s Office of Science by Brookhaven Science Associates, a limited-liability company founded by the Research Foundation for the State University of New York on behalf of Stony Brook University, the largest academic user of Laboratory facilities, and Battelle, a nonprofit applied science and technology organization.AttachmentsplashgraphicKaren McNulty Walsh
Brookhaven National Laboratory
6313448350
[email protected]

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Flat Ads Makes Its Mark at DMEXCO 2024: Showcasing Strength in Programmatic Advertising

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September 20, 2024

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COLOGNE, Germany, Sept. 20, 2024 /PRNewswire/ — In September, Flat Ads makes its mark at DMEXCO 2024, the prestigious European event of digital marketing and technology. The highly successful exhibition boasts 650 exhibitors, 850 speakers, and thousands of participants. At the event, Flat Ads showcased the strength of programmatic advertising platform in ad delivery, traffic optimization, and brand safety.

Flat Ads programmatic advertising platform has an exclusive developer traffic of 700 million and an extensive network spanning over 200 countries and regions worldwide. It cooperates with over 200 leading DSP/SSP partners, including FreeWheel, PubMatic and Criteo, leveraging an efficient and complete bidding system, as well as automatic delivery algorithms, to achieve precise marketing and advertising effectiveness maximization.
With its exclusive platform strategy algorithm, Flat Ads programmatic advertising platform can continuously conduct automatic exploration and matching based on the characteristics of DSP and traffic, optimize and adjust the algorithm model in real-time. This not only ensures the sustainability of DSP budgets, but also maximizes traffic utilization and enhances monetization revenue of advertisements.
Moreover, brand protection is among the top priorities of Flat Ads. In addition to accessing to authority agency Pixalate to test the effectiveness of ads, it has also accessed HUMAN, the global cybersecurity authority to safeguard its clients by preventing bot attacks, digital fraud and abuse, ensuring a stable, reliable, and secure programmatic advertising transaction platform.
By participating in DMEXCO 2024, Flat Ads showcased its outstanding strength and fruitful achievements in the programmatic advertising field, attracting the attention of numerous advertisers and developers for cooperation. Flat Ads boasts not only robust technical capabilities and innovative prowess, but also an active and open attitude towards emerging technologies, embracing and exploring them. It remains committed to providing more professional and efficient global marketing services to advertisers and developers worldwide, helping clients stand out in the fiercely competitive market and achieve business growth.
As a globally leading mobile advertising marketing platform, Flat Ads currently operates offices in Singapore, Indonesia, Hong Kong, and Guangzhou, serving over 1000 clients with global marketing solutions. If you’re interested in Flat Ads’ programmatic advertising services, please visit www.flat-ads.com.

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Fraud Detection & Prevention Market to Reach $252.7 Billion, Globally, by 2032 at 24.3% CAGR: Allied Market Research

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September 20, 2024

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The introduction of big data analytics, cloud computing services, and an upsurge in mobile payment drive the growth of the market.
PORTLAND, Ore., Sept. 20, 2024 /PRNewswire/ — Allied Market Research published a report, titled, “Fraud Detection & Prevention Market by Component (Solution and Service), Deployment Mode (On-Premises and Cloud), Organization Size (Large Enterprises and Small and Medium-sized Enterprises) and Industry Vertical (BFSI, IT and Telecom, Retail, Healthcare, Government and Defense, Manufacturing, Transportation and Logistics and Others): Global Opportunity Analysis and Industry Forecast, 2023-2032”. According to the report, the “fraud detection & prevention market” was valued at $29.5 billion in 2022, and is projected to reach $252.7 billion by 2032, growing at a CAGR of 24.3% from 2023 to 2032.

The introduction of big data analytics, cloud computing services, and an upsurge in mobile payment drive the growth of the market. In addition, the rise in the adoption of banking & financial sectors across the globe fuels the growth of the market. Moreover, continuous technological advancements are expected to provide lucrative opportunities for the growth of the market during the forecast period. On the contrary, the high cost of fraud detection and prevention solutions limits the growth of the fraud detection & prevention market.
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The solution segment held the highest market share in 2022. 
By component, the solution segment dominated the market in 2022, this dominance is driven by the increasing demand for advanced technological solutions that can effectively detect, monitor, and prevent fraudulent activities across various industries such as banking, e-commerce, and insurance. Solutions like AI-based fraud detection, machine learning algorithms, and behavioral analytics have become critical tools in identifying potential fraud in real time and reducing financial losses. However, the service segment is expected to witness the largest CAGR of 28.0%, this growth is driven by the increasing need for specialized services such as consulting, implementation, and maintenance to help organizations effectively integrate and optimize fraud detection solutions.
The BFSI segment held the highest market share in 2022.
By industry vertical, the BFSI segment accounted for the largest share in 2022. This is primarily due to the high frequency and sophistication of fraud targeting financial institutions, making fraud detection and prevention solutions a critical need in the BFSI sector. Financial transactions, online banking, and digital payments are particularly vulnerable to cyberattacks, phishing schemes, and identity theft, driving the sector’s substantial investment in advanced fraud detection technologies. However, the retail segment is expected to witness the largest CAGR of 32.7%. This anticipated growth is driven by several factors. Retailers are increasingly targeted by fraudsters due to the high volume of transactions and the sensitivity of customer data involved. As e-commerce and digital transactions expand, the need for advanced fraud detection and prevention solutions becomes more critical.
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Regional Insights: The North America region held the highest market share in 2022. 
By region, the fraud detection & prevention market was dominated by North America in 2022. North America, particularly the U.S., has a highly developed financial and technological infrastructure that supports advanced fraud detection solutions. The region’s significant investments in cybersecurity and fraud prevention technologies, combined with a high incidence of cyber threats, drive continuous innovation and adoption of sophisticated fraud management systems. 
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Key Industry Developments 
In February 2024, the U.S. Department of the Treasury announced that it has recovered over $375 million as a result of its implementation of an enhanced fraud detection process that utilizes Artificial Intelligence (AI) at the beginning of Fiscal Year 2023.In April 2024, Cognizant collaborated with FICO, to launch a cloud-based real-time payment fraud prevention solution powered by FICO Falcon Fraud Manager. The joint offering would leverage both firms’ artificial intelligence (AI) and machine learning (ML) technology to help banks and other payment service providers in North America protect their customers from fraud in the growing world of instant digital payments.In September 2022, Deutsche Bank collaborated with Visa, to help prevent online retail fraud. Merchants who process their e-commerce payments via Deutsche Bank can now use “Decision Manager,” an automated fraud detection system from Visa-owned company Cybersource.AVENUE- A Subscription-Based Library (Premium on-demand, subscription-based pricing model):
AMR introduces its online premium subscription-based library Avenue, designed specifically to offer cost-effective, one-stop solution for enterprises, investors, and universities. With Avenue, subscribers can avail an entire repository of reports on more than 2,000 niche industries and more than 12,000 company profiles. Moreover, users can get an online access to quantitative and qualitative data in PDF and Excel formats along with analyst support, customization, and updated versions of reports.
Get an access to the library of reports at any time from any device and anywhere. For more details, follow the link: https://www.alliedmarketresearch.com/library-access
About Us:
Allied Market Research (AMR) is a full-service market research and business-consulting wing of Allied Analytics LLP based in Wilmington, Delaware. Allied Market Research provides global enterprises as well as medium and small businesses with unmatched quality of “Market Research Reports Insights” and “Business Intelligence Solutions.” AMR has a targeted view to provide business insights and consulting to assist its clients to make strategic business decisions and achieve sustainable growth in their respective market domain.
We are in professional corporate relations with various companies, and this helps us in digging out market data that helps us generate accurate research data tables and confirms utmost accuracy in our market forecasting. Allied Market Research CEO Pawan Kumar is instrumental in inspiring and encouraging everyone associated with the company to maintain high quality of data and help clients in every way possible to achieve success. Each and every data presented in the reports published by us is extracted through primary interviews with top officials from leading companies of domain concerned. Our secondary data procurement methodology includes deep online and offline research and discussion with knowledgeable professionals and analysts in the industry.
Contact:David Correa1209 Orange Street,Corporation Trust Center,Wilmington, New Castle,Delaware 19801 USA.Int’l: +1-503-894-6022Toll Free: +1-800-792-5285UK: +44-845-528-1300India (Pune): +91-20-66346060Fax: [email protected] 
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G42 Collaborates with NVIDIA to Deliver Next-Generation Climate Solutions Using Earth-2

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September 20, 2024

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ABU DHABI, UAE, Sept. 20, 2024 /PRNewswire/ — G42, a leader in AI and cloud computing, today announced that it is partnering with NVIDIA to advance climate technology with a focus on developing AI solutions aimed at dramatically enhancing the accuracy of weather forecasting globally.

The collaboration builds on NVIDIA’s Earth-2, an open platform that accelerates climate and weather predictions with interactive, AI-augmented, high-resolution simulation. G42 and NVIDIA will initially focus on a square-kilometer resolution weather forecasting model that improves the accuracy of meteorological predictions.
Key to this initiative is the establishment of a new operational base and Climate Tech Lab in Abu Dhabi. This state-of-the-art facility will serve as a hub for research and development, driving forward both companies’ commitment to environmental sustainability. This facility will also mobilize the creation of tailored climate and weather solutions that leverage over 100 petabytes of geophysical data assets.
Peng Xiao, Group CEO of G42, said, “This initiative with NVIDIA is a testament to our commitment to applying AI in ways that not only innovate but also solve critical global challenges. Establishing the Earth-2 Climate Tech Lab in Abu Dhabi allows us to leverage our unique capabilities and insights to foster a sustainable future for the world.”
In addition to fostering innovation in climate technology, the initiative will focus on building a robust framework for integrating enhanced weather prediction capabilities with comprehensive data metrics and visualization. This will assist organizations worldwide in achieving their sustainability goals through well-informed, data-driven environmental strategies.
“Our collaboration with G42 marks a pivotal step toward harnessing AI to understand and predict climate phenomena with unprecedented accuracy,” said Jensen Huang, founder and CEO of NVIDIA. “The Earth-2 Climate Tech Lab will propel environmental solutions using the most advanced accelerated computing and AI technology to benefit millions of people around the world.”
By uniting G42’s AI expertise with NVIDIA’s computational acumen, this partnership aims to deliver transformative climate solutions that combine scientific accuracy with real-world applicability, driving impactful change across industries and ecosystems.
About G42
G42 is a technology holding group, a global leader in creating visionary artificial intelligence for a better tomorrow. Born in Abu Dhabi and operating worldwide, G42 champions AI as a powerful force for good across industries. From molecular biology to space exploration and everything in between, G42 realizes exponential possibilities, today. To know more visit www.g42.ai.
Media contactsMedia and PR Team, [email protected]

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