Artificial Intelligence
ForeseeHome AMD home monitoring real-world data analysis demonstrates substantial benefit for patients’ vision
Manassas, VA, April 06, 2021 (GLOBE NEWSWIRE) — Real-world data on the performance of the ForeseeHome® AMD Monitoring Program, a home-based diagnostic that helps detect the conversion from intermediate dry to wet age-related macular degeneration (AMD), was recently published in the Journal of Clinical Medicine as part of the “Diagnosis, Treatment and Prevention of Age-Related Macular Degeneration” special issue1. The large scale data analysis of 3.2 million tests showed that the use of ForeseeHome provided a significant benefit to patients by helping to detect their wet AMD earlier with better visual acuity, a factor previously shown2 to improve long-term visual outcomes of anti-VEGF treatment.
The retrospective analysis of medical records from the Notal Vision Diagnostic Clinic in Manassas, VA, medical provider of the ForeseeHome remote monitoring program, identified 306 eyes that converted to wet AMD between October 2009 and September 2018. Functional vision (20/40 or better) at conversion was maintained in 81% of patients in the real-world ForeseeHome cohort compared to only 34% in the IRIS® Registry real-world data using standard of care.2
Standard of care is defined by routine office visits and use of an Amsler grid, developed in the 1940s, is often recommended. Testing with the Amsler grid alone does not often result in early detection3 and wet AMD may be present for 6-12 months before detection and treatment, meaning that when a distortion is noticed on the Amsler grid, vision loss may have already progressed.4 It is difficult for physicians to rely on their patients to notice and report distortions, since compliance is often poor and difficult to verify.
“This real-world data analysis confirms that the use of ForeseeHome provides a significant benefit to patients as a means of increasing the early detection of wet AMD when vision is good,” said Allen C. Ho, MD, the study’s principal author and Director of Retina Research of Wills Eye Hospital and Professor of Ophthalmology at the Kimmel School of Medicine at Thomas Jefferson University. “Earlier detection of wet AMD with this FDA-cleared device is a strong predictor of better vision over time with current anti-VEGF therapy. ForeseeHome can be a useful strategy to monitor at-risk intermediate AMD and help protect vision. The era of at-home digital monitoring of medical conditions including AMD continues to evolve and improve for patient benefit.”
Additional authors of the paper include Jeffrey Heier, MD, Nancy Holekamp, MD, Richard Garfinkel, MD, Byron Ladd, MD, Carl Awh, MD, Rishi Singh, MD, Michael Elman, MD, Anat Loewenstein, MD and David Eichenbaum, MD. “Dry age-related macular degeneration is a chronic, slowly progressive disease that is characterized by gradual visual changes. The acute onset of wet disease can be difficult to detect with conventional means such as infrequent office visits and home Amsler Grid testing,” added Dr. Heier, Director of the Vitreoretinal Service and Director of Retina Research at Ophthalmic Consultants of Boston. “Artificial-intelligence enabled home monitoring between office visits could be extremely helpful in early detection of conversion and the ForeseeHome program is a meaningful complement to the at-risk dry AMD patient’s care plan.”
ForeseeHome is part of a comprehensive monitoring program provided by the Notal Vision Diagnostic Clinic, which includes patient engagement, compliance monitoring and alert generation services. Patients perform a short, daily test on an easy-to-use device and their results are automatically transmitted to the Diagnostic Clinic. When a statistically significant change in visual distortion is detected, the Diagnostic Clinic alerts the referring physician so they can determine the best course of action for the patient.
“The newly published real-word data shows that the performance of the ForeseeHome program resembles the findings from the randomized controlled AREDS2-HOME5 study, which ultimately led to Medicare coverage,” said Kester Nahen, PhD, CEO of Notal Vision. “The Notal Vision Diagnostic Clinic is proud to partner with physicians by providing complementary care for their patients.”
References
1. Ho AC, Heier JS, Holekamp N et al. Real-World Performance of a Self-Operated Home Monitoring System for Early Detection of Neovascular Age-Related Macular Degeneration, J. Clin. Med. 2021, 10,1355.
2. Ho AC, Kleinman DM, Lum FC, et al. Baseline Visual Acuity at Wet AMD Diagnosis Predicts Long-Term Vision Outcomes: An Analysis of the IRIS Registry, Ophthalmic Surg Lasers Imaging Retina. 2020;51:633-639.
3. Loewenstein A, Malach R, Goldstein M, et al. Replacing the Amsler grid: a new method for monitoring patients with age-related macular degeneration. Ophthalmology. 2003;110(5):966-970.
4. Ho AC, Albini TA, Brown DM, Boyer DS, Regillo CD, Heier JS. The potential importance of detection of neovascular age-related macular degeneration when visual acuity is relatively good. JAMA Ophthalmol. 2017;135(3):268-273.
5. Chew EY, Clemons TE, Bressler SB, et al; AREDS2-HOME Study Research Group. Randomized trial of a home monitoring system for early detection of choroidal neovascularization home monitoring of the Eye (HOME) study. Ophthalmology. 2014;121(2):535-544.
About Notal Vision
Notal Vision is a diagnostic services company that operates the Notal Vision Diagnostic Clinic, a medical provider with a proven platform for engaging patients and AI-enabled analyses of high-volume personalized health data that extends disease management from the clinic to the home to improve vision outcomes, reduce treatment burden, and improve health economics. www.notalvision.com
The ForeseeHome® AMD Monitoring Program is a comprehensive program, which includes an FDA-cleared device that monitors visual changes in intermediate dry AMD patients at risk of vision loss from undiagnosed wet AMD. The clinical utility for ForeseeHome was established in the Home Monitoring of The Eye (HOME) Study, part of the National Eye Institute-sponsored AREDS2 study, in which 94% of patients using ForeseeHome twice weekly who progressed to wet AMD, maintained 20/40 or better vision compared to only 62% of patients whose diagnosis was at a routine eye exam or a visit triggered by symptoms. Based upon the robust level-1 evidence and compelling clinical outcomes demonstrating the ability to detect choroidal neovascularization (CNV) earlier, the ForeseeHome AMD Monitoring Program gained Medicare coverage in 2016. To learn more, visit www.foreseehome.com.
Notal Vision’s Home OCT system will enable wet AMD patients to perform technician-free OCT testing at home with rapid and self-guided fixation – critical components, especially for elderly patients frequently with pre-existing vision loss. The Notal OCT Analyzer (NOATM), a proprietary machine learning algorithm, developed in-house, performs automated analysis of the Home OCT scans and generates a report to the physician when a physician specified change in disease activity is detected. The Notal Vision Diagnostic Clinic provides referring physicians patient data via an online portal. In addition, physicians will be provided 24/7 access to all of their patients’ B-scan images from each Home OCT test with the location of the fluid annotated on each B-scan. Following physician receipt of an alert report, patients may be brought to the office for evaluation and treatment at the doctor’s discretion. NOA can also analyze the output of other commercial OCT devices, and published study data indicate that the performance of NOA in detecting disease activity was similar to that of retina physicians when each was compared to a panel of experts. Notal Vision’s Home OCT has the potential to support current and future advances in retinal disease management.
Artificial Intelligence
SEMI Consortium to Develop Cybersecurity Strategy and Roadmap for the Semiconductor Industry in NIST Framework
MILPITAS, Calif., Sept. 30, 2024 /PRNewswire/ — Seeking to strengthen the semiconductor industry’s resilience to cybersecurity threats, the global association SEMI today announced the creation of a strategic roadmap for cybersecurity implementation throughout the industry. The SEMI Semiconductor Manufacturing Cybersecurity Consortium (SMCC) has partnered with the National Institute of Standards and Technology (NIST) to develop a semiconductor manufacturing industry profile for NIST Cybersecurity Framework 2.0 (CSF 2.0) that will serve as the foundation for the aforementioned roadmap. NIST plans to publish the profile in mid-2025.
According to research by the Identity Theft Resource Center, cyberattacks rose by 72 percentage points in 2023 over the previous all-time high in 2021. As semiconductor factories become increasingly connected and autonomous, the industry must respond to the growing security vulnerabilities associated with this next level of digital reliance and align with broader government efforts to secure the building blocks of technologies vital to society.
“Semiconductors are integral to both national security and the global economy – we need to do everything in our power to protect the industry,” said Cherilyn Pascoe, Director of the National Cybersecurity Center of Excellence (NCCoE) at NIST. “NIST is pleased to partner with SEMI SMCC for the development and adoption of a NIST Cybersecurity Framework 2.0 Profile for Semiconductor Manufacturing. This collaboration is important to identify and reduce cybersecurity challenges in semiconductor manufacturing.”
“It’s important to recognize and address the unique cybersecurity challenges facing the semiconductor industry,” said Jennifer Lynn, SMCC Working Group Chair and Semiconductor Cybersecurity Lead at IBM Research. “This community profile could allow us to better identify and execute a path forward.”
In support of the 2023 National Cybersecurity Strategy’s strategic objective to secure global supply chains for information, communications and operational technology products and services, the White House Office of the National Cyber Director (ONCD) included a Cybersecurity Framework Profile as part of initiative 5.5.5 in the National Cybersecurity Strategy Implementation Plan Version 2. SMCC recognized the need for a cybersecurity community profile specific to semiconductor manufacturing and worked with the federal government to develop one.
“Unlike air, space, land, and sea, cyberspace is the only battle domain created entirely by human hands,” said Anjana Rajan, Assistant National Cyber Director for Technology Security at ONCD, during the Global Executive Cybersecurity Forum at SEMICON West 2024. “This means we have both the power and the responsibility to shape it. The future of cyberspace where defenders have an inherent advantage over attackers starts with preparation, and that preparation must begin with securing the building blocks.”
Prior to completion, the community profile will open for public review and commentary in accordance with NIST’s official process. The review period has yet to be announced. The community profile is part of a broader NIST strategy to further standardize cybersecurity protocols for the semiconductor sector, in line with profiles for other industries.
“With the committed resources and support from NIST to support SMCC working groups, we’ll be able to accelerate the development of this semiconductor manufacturing industry community profile creation,” said Brian Korn, Director for SMCC and Staff Technologist focused on Cybersecurity and Automation at Intel Foundry.
SMCC will provide cybersecurity recommendations for semiconductor manufacturing equipment, information on implementation, and updates on the development of the community profile. For more information, visit the project webpage or contact [email protected].
SMCC working groups are engaged with the SEMI Standards program to create a standards-based approach supporting the semiconductor ecosystem by leveraging the program’s 50-year history of industry alignment. SMCC is currently working on developments to two cybersecurity standards:
E187: Specification for Cybersecurity of Fab EquipmentE188: Specification for Malware-Free Equipment IntegrationAbout SMCC
The Semiconductor Manufacturing Cybersecurity Consortium (SMCC) is a SEMI technology community founded in 2024 to develop and promote a standard based, semiconductor industry wide approach to improve cybersecurity and accelerate implementation of actionable solutions. The vision of SMCC is to strengthen cyber resilience and protection of the global semiconductor supply chain against evolving threats. SMCC’s reach extends all over the world and enables our members to connect and collaborate on specific cybersecurity issues and challenges affecting different regions. It focuses on important key topics and seeks to find solutions that will benefit the entire industry.
About SEMI
SEMI® is the global industry association connecting over 3,000 member companies and 1.5 million professionals worldwide across the semiconductor and electronics design and manufacturing supply chain. We accelerate member collaboration on solutions to top industry challenges through Advocacy, Workforce Development, Sustainability, Supply Chain Management and other programs. Our SEMICON® expositions and events, technology communities, standards and market intelligence help advance our members’ business growth and innovations in design, devices, equipment, materials, services and software, enabling smarter, faster, more secure electronics. Visit www.semi.org, contact a regional office, and connect with SEMI on LinkedIn and X to learn more.
About NIST
The National Institute of Standards and Technology (NIST) was founded in 1901 and is now part of the U.S. Department of Commerce. NIST is one of the nation’s oldest physical science laboratories. Congress established the agency to remove a major challenge to U.S. industrial competitiveness at the time — a second-rate measurement infrastructure that lagged behind the capabilities of the United Kingdom, Germany and other economic rivals.
The National Cybersecurity Center of Excellence (NCCoE) under NIST is a collaborative hub where industry organizations, government agencies, and academic institutions work together to address businesses’ most pressing cybersecurity challenges. This public-private partnership enables the creation of practical cybersecurity solutions for specific industries or broad, cross-sector technology challenges. Working with technology partners—from Fortune 50 market leaders to smaller companies specializing in IT security— the NCCoE develops modular, easily adaptable example cybersecurity solutions demonstrating how to apply standards and best practices using commercially available technology.
About ONCD
The Office of the National Cyber Director (ONCD) advises the President of the United States on cybersecurity policy and strategy. Established by Congress in 2021, ONCD is a component of the Executive Office of the President at the White House. The Office spearheaded the development of the President’s National Cybersecurity Strategy, which President Biden issued on March 2, 2023. ONCD coordinates a whole-of-government approach to implement the National Cybersecurity Strategy.
ONCD’s mission is to advance national security, economic prosperity, and technological innovation through cybersecurity policy leadership. In carrying out its directive, ONCD works closely with White House and interagency partners, as well as with all levels of government, America’s international allies and partners, non-profits, academia, and the private sector, to shape and coordinate federal cybersecurity policy. Guided by the President’s vision, as articulated in the National Cybersecurity Strategy, ONCD is working to create a more equitable, safe, and resilient interconnected world in which every American can thrive and prosper.
Association Contact Samer Bahou / SEMIPhone: 1.408.943.7870Email: [email protected]
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Unlimited access to training materials empowers enterprise customers to accelerate time-to-market for AI and data-driven applications
REDWOOD CITY, Calif., Sept. 30, 2024 /PRNewswire/ — MinIO, the leader in high-performance object storage for AI, today announced the MinIO Learning Subscription, featuring unlimited access to MinIO’s full portfolio of training content. Through the subscription, training is delivered through a combination of videos, practical exercises and hands-on labs, designed to help customers accelerate onboarding for new staff and shorten time-to-market.
The MinIO Learning Subscription learners will soon have more than 250 videos organized into courses for MinIO administrators, developers, and Kubernetes operators. The content is indexed and searchable, allowing for targeted, just-in-time performance support. Additionally, students can also choose to learn on the go using the mobile app.
“Enterprises seeking to leverage artificial intelligence and machine learning to transform their business need infrastructure at a level of scale and performance previously unthinkable,” said Pete Hnath, Head of Training and Certification at MinIO. “The MinIO Object Store is integral to reach petabyte and even exabyte scale while delivering the performance AI/ML requires. The MinIO Learning Subscription offers an accelerated on ramp to prepare teams to deploy and manage object storage at scale.”
Validation of skill transfer and job role readiness is critical for project leaders. The MinIO Learning Subscription includes a voucher for each named learner to attempt the MinIO Certified Administrator – Practitioner exam.
The MinIO Learning Subscription enables users to learn by doing with comprehensive, hands-on labs. Learners progress through lab-focused video demos, followed by hands-on guided exercises, and then outcome focused end-of-module labs to build the applied skills needed to take full advantage of MinIO’s powerful capabilities in production environments. Lab exercises can be completed on the student’s local system using basic Docker compose scripts. Subscribers also receive exclusive access to a trial license of MinIO Enterprise Object Store to learn about features including caching, catalog, firewall, observability, and Key Management Server (KMS) that are unique to the enterprise offering.
Similarly, interacting with others is integral to the learning experience. The MinIO Learning Subscription includes an engaging peer-to-peer learning model where students can ask questions, get answers, and see others’ contributions inline with the course content. The MinIO curriculum engineers are also directly accessible to students. This provides a fluid and integrated model for collaborative learning missing from many other online learning experiences.
Technical enablement is critical to customer success. At $700 per learner (with volume discounts available starting at just 10 learners), the MinIO Learning Subscription is priced to encourage customers to invest in their team in preparation for project success. To learn more, visit the MinIO training at https://min.io/training.
About MinIOMinIO is pioneering high-performance object storage for AI/ML and modern data lake workloads. The software-defined, Amazon S3-compatible object storage system is used by more than half of the Fortune 500. With 1.7B+ Docker downloads, MinIO is the fastest-growing cloud object storage company and is consistently ranked by industry analysts as a leader in object storage. Founded in November 2014, the company is backed by Intel Capital, Softbank Vision Fund 2, Dell Technologies Capital, Nexus Venture Partners, General Catalyst and key angel investors.
Media Contact: Tucker Hallowell, [email protected]
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SHANGHAI, Sept. 30, 2024 /PRNewswire/ — Fourier, the Shanghai-based robotics company, announces the launch of GR-2, the latest addition to its GRx humanoid robot series. With remarkable upgrades across hardware, design, and software, GR-2 marks a new milestone in the field of humanoid robotics.
Next-Level Hardware Design
GR-2 builds upon the success of its predecessor, GR-1 — the world’s first mass-produced humanoid robot. Standing at 175 cm and weighing 63 kg, GR-2 offers 53 degrees of freedom and a single-arm load capacity of 3 kg, enabling it to tackle more complex tasks.
The new robot features a detachable battery with the capacity doubled, extending runtime by an hour. This upgrade boosts GR-2’s adaptability, making it capable of handling a broader range of challenges, such as long-distance walking.
Engineering Breakthroughs for Developers
GR-2 features integrated cabling design for power and communication transmission, allowing concealed wires and more compact packaging. The efficient layout optimizes space for easier modularization and greater adaptiveness for application-oriented customization.
To simplify the control system and reduce maintenance, Fourier re-designed GR-2’s joint configuration, shifting from a parallel to a serial structure. It improves debugging, lowers manufacturing costs, and enhances the robot’s ability to rapidly learn and transition from AI simulation to real-world applications.
12-Degrees-of-Freedom Dexterous Hands: Precision in Motion
GR-2 introduces 12-DoF dexterous hands—double the dexterity of previous models. Designed to mirror the flexibility of human physiology, these hands adapt seamlessly to complex tasks with greater precision.
Equipped with six array-type tactile sensors, GR-2 can sense force, identify object shapes and materials, and adjust its grip in real time for optimal manipulation in dynamic settings.
Supporting multiple upper-limb teaching modes—VR remote control, lead-through programming, and direct command—GR-2 can record a comprehensive set of operational data, from motion paths to tactile responses. The robust data collection expects to bridge the gap between virtual models and real-world applications, pushing the boundaries of robot training and deployment further.
FSA 2.0: Powering Dynamic Mobility
Fourier breaks new ground in humanoid robotics by incorporating human-like motion into GR-2’s design. To optimize its movement, the company developed seven distinct FSA actuators for GR-2, each tailored to meet the specific torque demands of every joint.
With peak torques exceeding 380 N.m, FSA 2.0 boosts GR-2’s agility and dynamic capabilities. The dual-encoder system doubles control accuracy, ensuring precise movements even in high-pressure environments. Designed for both speed and precision, FSA 2.0 empowers GR-2 to navigate complex tasks with greater flexibility.
Optimized Tools for Innovative Development
Fourier prioritizes the developer’s experience. The company optimized GR-2’s development platform by introducing a new software development kit compatible with mainstream programming languages such as ROS. Developers can have easy access to a robust suite of pre-optimized modules for machine vision, path planning, and force feedback control through intuitive APIs.
Supporting frameworks such as NVIDIA Isaac Lab and Mujoco, the new platform empowers developers to focus on innovation, streamlining their workflow and elevating the robotics development experience.
“GR-2 is a big step into the future of humanoid robotics,” said Alex Gu, CEO of Fourier. “We’re passionate about building the most intuitive embodied agent for AI, allowing it to engage with the physical world in ways like never before. Fourier is excited to have developers, researchers, and enterprises join us on this incredible journey.”
Fourier GRx series sets new standards in humanoid robotics with its emphasis on AI integration. In view of the future evolution of humanoid robot entities, the company outlines six key areas for development—locomotion, manipulation, cognition, bionic design, user experience, and commercial viability. The launch of GR-2 marks a new step toward future breakthroughs in human-robot collaboration.
About Fourier
Founded in 2015, Fourier is a leading general-purpose robotics company. At Fourier, our mission is to leverage full-stack robotics technology to enrich people’s lives. We’re headquartered in Shanghai, China with a team of over 500 employees globally. For more information about Fourier, please visit: www.fftai.com.
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