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PharmaNest Announces New Pre-Clinical and Clinical NASH Data to Be Presented at the AASLD – The Liver Meeting Digital Experience™ (TLMdX) 2021

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PRINCETON, N.J., Nov. 12, 2021 (GLOBE NEWSWIRE) — PharmaNest is a digital pathology and artificial intelligence company that is focused on the development and validation of novel standards for quantification of the histological phenotype(s) of fibrosis and associated histological features for drug discovery and development. Launched in 2019, PharmaNest’s FibroNest™ multi-vendor Quantitative Image Analysis and Quantitative AI platform automates the quantification of fibrosis and disease activity (Steatosis, Ballooning and Inflammation) for both non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), using digital images of stained tissues. It is a for-research-only-use project at this time.

As a multi-vendor platform, FibroNest is compatible with all kinds of digital image formats, including conventional digital pathology-stained slides (Picro Sirius Red, Trichrome or Antibody stains for fibrosis) acquired by both FDA-approved, digital pathology scanners and other digital microscopes.

At the 2021 AASLD | The Liver Meeting Digital Experience™ (TLMdX), PharmaNest and its world-class academic and industry collaborators present results that demonstrate the translational capabilities of FibroNest across the drug discovery and development continuum including:

  • The quantification of the progression of fibrosis in Human in-vitro 3D NASH tissue models and their response to Alk5 inhibitors and anti-TGB beta treatments – showing the utility of the combined technologies to accelerate the discovery of novel anti-fibrotic compounds, in a collaboration with InSphero (Schlieren, Switzerland).
  • The comparison of Whole Slide Digital Imaging and Two Photon (Second Harmonic Generation) digital imaging using FibroNest to evaluate the anti-fibrotic and anti-steatotic effects of FXR agonists in Leptin-deficient mice food with high-fat diets (NASH model), in a collaboration with Intercept, Inc. (New York, USA).
  • The development and validation of a highly sensitive, continuous digital pathology score, used to classify patients between NASH Fibrosis stages of F2 and F3, with a sensitivity and specificity performance of more than 90%, in a collaboration with Virginia Commonwealth University (Richmond, USA), Bristol Myers Squibb (Princeton, USA) and University of California (San Diego, USA).
  • The quantification of the histological phenotypes of fibrosis in LEAN and OBESE patients with NAFLD and F2 / F3 fibrosis, and the comparison of these phenotypes, in a collaboration with the Yokohama City University School of Medicine (Yokohama, Japan) and The Chinese University of Hong Kong (Hong Kong).
  • The development of a digital pathology score to automatically classify F1 NASH patients into sub-stages, such as F1a, F1b and F1c, in a collaboration with Lipocine, Inc (Salt Lake City, USA) and University of California (San Diego, USA).

In addition, several other communications at AASLD | TLMdX, 2021 will present the contribution of FibroNest’s Digital Pathology and Quantitative AI platform in the quantification of novel drugs investigated in Phase2b studies, such as the LPCA 1144 Therapy (a collaboration with Lipocine, Inc., Salt Lake City, USA).

These results will be presented at The Liver Meeting Digital Experience™ (TLMdX) 2021 at the following poster presentations.

Please contact PharmaNest to schedule one-on-one or group webinar presentations.

AASLD “Poster of Distinction“:

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#1704 – Is the histological phenotype of Fibrosis different between LEAN and OBESE NASH patients? Michihiro Iwaki (1), Li Chen (2), Mathieu Petitjean (2), Atsushi Nakajima (1), Vincent Wai-Sun Wong (3) – (1) Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Japan (2) PharmaNest Inc, Princeton, New Jersey, USA (3) Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong. 

#1601 – Evaluation of the multivendor performance of a novel histology-based fibrosis phenotypic composite score and its correlation with NASH-CRN Fibrosis scores in patients with NASH Li Chen (1), Michael Lung (2), Cynthia Behling (3), Anthony Azzara (4), Diane Shevell (4), Arun J. Sanyal (5), Mathieu Petitjean (1) – (1) PharmaNest, Princeton, NJ, USA (2) Pacific Rim Pathology, San Diego, CA, USA (3) Department of Pediatrics University of California, San Diego, CA, USA (4) Bristol Myers Squibb, Princeton, NJ, USA (5) Virginia Commonwealth University, Richmond, VA, USA

#LP41 – LPCN 1144 Therapy demonstrates Histologic Benefits in the Phase2 LiFT Study in NonAlcoholic Steatohepatitis (NASH) Subjects. Arun J Sanyal (1), Benjamin J Bruno (2), Kilyoung Kim (2), Shadi Mehraban (2), Kongnara Papangkorn (2), Anthony DelConte (2),(3), Nachiappan Chidambaram (2) and Mahesh V Patel (2), (1) Div of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, VA, USA, (2) Lipocine Inc., Salt Lake City, UT, USA, (3) Department of Pharmaceutical/Healthcare Marketing, Saint Joseph’s University, Philadelphia, PA, USA

#1908 – Digital Pathology Image Analysis Accurately Quantifies Anti-fibrotic and Anti-steatotic effects of FXR Agonists Using Multiple Histological Methods. Li Chen (1), Mary Erickson (2), Luciano Adorini (2), Jonathan Roth (2), Mathieu Petitjean (1) – 1 PharmaNest, Princeton, USA, 2 Intercept Pharmaceuticals, San Diego, USA

#1587 – Continuous staging of NASH Patients at low (F1) Fibrosis Severity: Evaluation of the performance of a novel histology-based fibrosis phenotypic composite score and predictive AI tools. Li Chen (1), Dmitry Fedorov (2), Mathieu Petitjean (1), Benjamin J. Bruno (3), Kilyoung Kim (3), Cynthia Behling (4), Anthony DelConte (5), Nachiappan Chidambaram (3)  – (1) PharmaNest Inc, Princeton, New Jersey, USA (2) ViQi Inc, Santa Barbara, California, USA (3) Lipocine Inc. Salt Lake City, Utah, USA (4) Pacific Rim Pathology, San Diego, CA, USA (5) Saint Joseph’s University, Philadelphia, PA, USA

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# 1183 – SB CCA.Mdr2-/-, a new mouse model of Cholangiocarcinoma arising in the PSC-like settings of progressive biliary injury and fibrosis. Pinzhu Huang1, Guangyan Wei 1, Shuangshuang Zhao1, Disha Badlani1, Kahini Vaid1, Li Chen2, Mathieu Petitjean2, Xin Chen3, Gregory Gores4, Yury Popov1 – (1) Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, (2) PharmaNest, Inc, Princeton, NJ, (3) University of California, San Francisco, CA and (4) Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN

#1362 – Evaluation of anti-fibrotic effects of compounds in human 3D NASH model using phenotypic quantification of fibrosis digital pathology images. Li Chen (1),Simon Strӧbel (2), Mathieu M. Petitjean (1), Eva Thoma (2), Radina Kostadinova (2) (1) PharmaNest, Princeton, NJ, USA (2) InSphero AG, Schlieren, Switzerland

PharmaNest | Press contacts

Dr. Mathieu M.  Petitjean

CEO

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[email protected]

Related Images

Image 1: FibroNest Liver NASH Biopsy Quantitative Image Analysis

FibroNest provides Could-based Quantitative Image Analysis (NASH Liver Biopsy) and uses Quantitative AI to establish continuous scores to stage disease severity.

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China Mobile and Global Mobile Operators Explore Pathways to a More Intelligent Future at Global Partnership Executive Conference

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SHANGHAI, June 26, 2024 /PRNewswire/ — China Mobile held the Global Partnership Executive Conference under the Hand-in-Hand Program (hi-H Program) with the theme of “Hand-in-Hand, Leap Forward in Intelligent Future” on 25 June during MWC Shanghai 2024.

The conference was attended by 78 operators from over 30 countries and regions, with more than 300 executives and industrial experts. It featured keynote speeches, a fireside chat, roundtable discussions, and a launch ceremony, reflecting a new chapter of cooperation with international operator partners. Mr. Gao Tongqing, Executive Vice President of China Mobile, attended the conference and delivered a speech.
Mr. Gao Tongqing stated that China Mobile is actively promoting cooperation with overseas operators, building high-quality capabilities, and empowering global partners each other. 
Firstly, China Mobile is continuously building digital intelligent infrastructure. It has more than 1.9 million 5G base stations, with nearly 800 million 5G package users and serving more than 25 million industry customers and over 30,000 5G commercial users, while accelerating the development of innovative products.
Secondly, China Mobile promotes the integration of AI into the businesses and has developed the “Jiutian Zhongqing” foundation model, which has been deployed in more than 10,000 “AI+” projects across dozens of industries.
Thirdly, China Mobile is actively advancing digital intelligent capabilities for global partners, providing high quality products and empowering partners in areas such as 5G private networks and industry applications, to create shared success.
The keynote addresses delivered by China Mobile, Orange Wholesale International, Singtel, e& and TIM Brasil provided a powerful vision for the transformation required for the telecoms industries to thrive in the hyper-connected, technology-driven landscape.
Emmanuel Rochas, CEO of Orange Wholesale International, set the tone by emphasizing the critical importance of forging strategic partnerships and collaborative ecosystems. He asserted, “Strategic collaboration has become crucial for traditional carriers in today’s fast-paced business environment. By drawing on the expertise of partners from diverse industries, operators can stay ahead of new technologies, adapt to evolving markets and effectively serve their customers high expectation towards connectivity services – achieving significant business impact.”
Echoing this sentiment, Anna Yip, Deputy CEO of Singtel Singapore, underscored the pivotal role that the telecommunications sector plays in enabling the emergence of new strategic industries through the transformative power of 5G and AI. She stated, “The telecom industry plays a pivotal role in the emergence of new strategic industries based on transformative technologies like 5G and artificial intelligence. By forging impactful partnerships, we unlock new opportunities for businesses and help economies and communities tackle complex global challenges.”
“As customer expectations continue to rapidly evolve in our digital-first world, organizations must undergo profound transformations to stay competitive and deliver exceptional experiences,” said Rashid Ali Al Ali, Senior Vice President International Data of e&. “By embedding a true customer-centric mindset into our business strategy, operations, and culture, we are able to anticipate and meet the changing needs of our customers, driving sustainable growth for our company.”
Alberto Griselli, CEO of TIM Brasil, further explored how telecom operators can expand beyond connectivity-centric offerings to unlock new revenue streams and transform the future. “Developing innovative, value-added solutions that address evolving customer needs and pain points will position telcos as key enablers of the digital economy. Promoting digital transformation, we have an opportunity to contribute to building a more inclusive and diverse society and moving towards a more circular, low-carbon future,” he said.
Under the theme “Collaborate to Innovate, Shape the Intelligent Future” leading telecom operators from around the world gathered for an exclusive ceremony to celebrate their shared commitment to “Going Global”. This prestigious event featured distinguished guests from companies such as e&, Singtel, TIM Brasil, CTM, and SmarTone to strengthen existing partnership and forge new alliances that will shape the intelligent future of telecommunications. With a vision to chart the course for the future of international partnerships, through this event, China Mobile aims to infuse new energy into the global telecom ecosystem and showcase the power of collaboration in leaping forward in the intelligent future.
About China Mobile International Limited
China Mobile International Limited (CMI) is a wholly owned subsidiary of China Mobile. In order to provide high quality services to meet the growing demand in the international market, China Mobile established CMI in December 2010, headquartered in Hong Kong, China. CMI has expanded its footprint in 38 countries and regions. Leveraging the strong support by China Mobile, CMI is a trusted partner that provides comprehensive international information services and solutions to enterprises, carriers and mobile users. please visit www.cmi.chinamobile.com
About Hand-in-Hand Program
Established in 2015 by China Mobile, the Hand-in-Hand Program (“hi-H Program”) is a global partnership initiative which brings together various organizations from across the telecoms sector under the shared vision of providing seamless, borderless products and services worldwide. By gathering major players from different sectors together, hi-H combines strengths from across the industry to enhance each member’s ability to overcome challenges and adapt to industry changes.
About GTI
GTI, founded in 2011, has been dedicated to constructing a robust ecosystem of TD-LTE, speeding up the commercialization of TD-LTE and promoting the convergence of LTE TDD and FDD. As 4G evolves to 5G, GTI 2.0 was officially launched at the GTI Summit 2016 during the Mobile World Congress 2016 in Barcelona, aiming not only to further promote the evolution of TD-LTE and its global deployment, but also fostering a cross-industry innovative and a synergistic 5G ecosystem.
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Marketing Intelligence Platform Funnel Acquires Measurement Firm Adtriba

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The acquisition combines Funnel’s data collection and analysis acumen with Adtriba’s complex machine-learning measurement tools, optimized for the likes of Adidas and Sony
STOCKHOLM, Sweden and HAMBURG, Germany, June 26, 2024 /PRNewswire/ — Funnel (www.funnel.io), the marketing intelligence platform, has today announced its acquisition of the marketing measurement company Adtriba (www.adtriba.com). The move expands and enhances Funnel’s product offering, building on its core Data Hub and visualization to offer more advanced marketing analytics and Unified Marketing Measurement (UMM). The acquisition consolidates Funnel’s position as a global frontrunner in marketing intelligence with the company generating more than $50 million in Annual Recurring Revenue (ARR). 

At a time when it is becoming increasingly complicated to collect, analyze and measure marketing data from online and offline channels, this acquisition strengthens the sophistication of Funnel’s marketing insights. Funnel’s thousands of customers will be provided with a market-first integrated measurement technology, based on Adtriba’s capabilities, within one unified platform. 
Marketing is often a company’s biggest investment, and yet many elements of advertising campaign effectiveness remain intangible and unquantifiable to the marketers who design them. Working with the likes of Adidas, Sony, FlixBus and Samsung, Funnel and Adtriba’s combined solution accurately identifies the impact of budgetary spend and campaign ROI through an AI-powered model that triangulates marketing mix modelling (MMM), multi-touch attribution (MTA) and incrementality testing methodologies.
In 2021, the marketing attribution software market was valued at $3.1 billion, boosted by the expansion of online marketing channels and emerging technologies such as cloud computing and AI-powered solutions. Growing at a CAGR of 15.5% from 2022 to 2031, the market is projected to reach $12.9 billion by 2031. 
Fusing Data Intelligence and Machine Learning
Founded in Stockholm in 2014, Funnel has grown to over 300 employees and is trusted by globally recognized brands such as Home Depot and Uber, as well as agency clients across B2B and B2C like Publicis and Havas. Data gleaned from every marketing channel, from Google Ads to LinkedIn, Salesforce to Facebook Ads, is collated and presented across easy-to-use dashboards in Funnel’s Data Hub to support companies with the gathering, reporting and exporting of information. 
Hamburg-headquartered Adtriba has grown to 18 employees since launching in 2015 and has been used by multinational companies like FlixBus and Montblanc for data-driven marketing measurement and optimization across all channels.
In the coming months, Adtriba’s software will be fully incorporated into Funnel’s platform, creating an integrated marketing intelligence platform for measurement and ‘triangulation’ through blending MMM, MTA and incrementality testing methodologies. Combining these methodologies is the best way to measure marketing activities accurately and to determine what is working and why. With more businesses shifting from pure performance marketing to holistic full-funnel approaches, it is crucial to track marketing spending impact, particularly in the upper funnel. 
Measurement has been largely inaccessible to companies due to its perceived cost, complexity, and lack of real-time updates. Restrictions on third-party cookies, privacy and data collection on iOS and Android, and relying on last-click tracking have all made measuring more difficult. By integrating Adtriba’s proprietary, machine-learning-powered measurement technology into Funnel’s Marketing Intelligence platform, measurement becomes faster, more affordable, and more accurate, removing barriers to entry for marketers. This holistic marketing measurement, referred to as UMM, is at the forefront of data analytics and has previously been restricted to larger enterprises.
Partnership-turned-Full Acquisition
Owing to Funnel and Adtriba’s multi-year partnership that predates this deal, the acquisition is a natural step towards the delivery of a robust solution for existing and future customers, providing a strong and technologically sound value-add.
As before, the workforces at both companies will continue their activity in Sweden and Germany respectively. Adtriba’s employees will contribute to the Funnel product team and maintain their Hamburg office, and the marketing and sales teams will merge. Both companies’ existing customers will be shared after this acquisition without disrupting Funnel and Adtriba’s product offerings. 
As soon as this fall, Funnel’s Marketing Intelligence platform will be greatly enhanced by Adtriba’s solution, expanding the scope for what brands can do with their marketing budgets and offering solution partners a broader, more deeply integrated platform.
Fredrik Skantze, CEO of Funnel, says: “It is one thing to offer clients data and information about their marketing spend; it is quite another to give them marketing intelligence. Add to this Adtriba’s proprietary, world-class measurement technology and this is a very powerful tool for marketers. At Funnel, we are bold in wanting to be the definitive Marketing Intelligence Platform. Through this acquisition, we are well on the way to achieving that goal. If our previous partnership with Adtriba is any indication, I am more than confident this deal will be a success. We are pleased to be welcoming Adtriba’s team to Funnel and we cannot wait to begin the integration of our technologies.”
Adtriba CEO János Moldvay — who will become VP of Measurement at Funnel — adds, “As Adtriba continues to compete in the measurement technology arena, we are thrilled to announce this next step in our journey. Measurement platforms are dependent on accurate, and timely data that shows a complete picture, something that is out of reach for many businesses in our space. However, through our previous partnership with Funnel, we identified their Data Hub as a key differentiator for our measurement product. By integrating Adtriba into Funnel’s Marketing Intelligence platform, Adtriba will more effectively compete in the measurement market and access a large base of data-driven companies at the top of their game.”
About Funnel
Founded in Stockholm in 2014 by Fredrik Skantze (CEO) and Per Made (CMO), Funnel (www.funnel.io) is the Marketing Intelligence Platform that is trusted by globally recognized brands such as Adidas and Sony. Funnel’s unique Data Hub serves as the foundation for marketing reporting for thousands of organizations. With its cutting-edge platform, users can automatically collect, model, visualize, and analyze data from over 500 marketing platforms. The firm has grown to over 300 employees and generated over $50M in ARR in 2023, consistently featuring in the FT 1000 list of Europe’s fastest-growing companies.
About Adtriba 
Adtriba (www.adtriba.com) is a Hamburg-headquartered marketing measurement business founded by János Moldvay (CEO) in 2015. Adtriba measures the impact of budgetary spend and campaign ROI through a machine-learning-powered model that triangulates marketing mix modelling, multi-touch attribution and incrementality testing marketing methodologies. Used by the likes of FlixBus and Montblanc, the company has grown to 18 employees. 
Press Contact detailsBill Cropper, [email protected], +44 7305 592555Carl Ronander, [email protected] , +46768836266
This information was brought to you by Cision http://news.cision.com
https://news.cision.com/funnel/r/marketing-intelligence-platform-funnel-acquires-measurement-firm-adtriba,c4005564
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Wondershare Filmora Premieres Documentary ‘Gen Z in Action’ to celebrate VidCon 2024: A Deep Dive into the Minds Shaping Influencer Culture, Content Creation, and AI

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VANCOUVER, BC, June 26, 2024 /PRNewswire/ — In celebration of the 15th anniversary of VidCon and 19 years of YouTube, Wondershare Filmora, a leading video editing software company, is proud to announce the release of its new documentary, “Gen Z in Action.” This insightful film delves into the lives of Gen Z content creators, showcasing their dedication, innovation, and the unique challenges they face in today’s digital landscape. 

Filmed in Vancouver, BC, the documentary features in-depth interviews with over 10 Gen Z creators who have found fame and success in photography, music, and cosplay. Among the highlighted creators are Fearfiction, a dedicated cosplayer; Mathew, a relentless musician; and Maxwell, an emerging photographer. These individuals share their journeys, providing a candid look into their lives, work, and creative processes. 
“Gen Z in Action” also explores content creation, digital nativity, the effects of AI and influencer culture, and the future of the generation as they explore, define, and create a new era for society. 
Christy, VP of Wondershare, expressed her enthusiasm for the project, stating, “At Wondershare, we believe in the power of creativity and the importance of providing creative tools to the voices of the next generation. ‘Gen Z in Action’ not only highlights the incredible talents and innovations of Gen Z creators but also challenges the misconceptions often associated with them. We are excited to share their stories and inspire others to see the potential and drive that this generation brings to the AI era.” 
Alongside the documentary, Wondershare Filmora has published a white paper titled “Gen Z in Action.” Based on a survey of nearly 1,000 Gen Zers, this paper dives into their world, showcasing their dedication and innovation while debunking misconceptions about Gen Z. The documentary emphasizes their creativity, diligence, and passion to grow in their own way.  
About Filmora 
Filmora is designed with its user in mind, featuring smoother performance and an intuitive user interface. With advanced AI functions, over 220,000 creative assets, commercially available music, 3D LUTs, effects, and pre-set templates, you have everything you need to perfect your creative vision. Filmora is available on iOS, Android, macOS, and Windows. To try it for free, visit filmora.wondershare.com. Follow Wondershare Filmora on YouTube, TikTok, Instagram, and Facebook to learn more 
About Wondershare 
Wondershare is globally recognized as a software company committed to delivering innovative solutions for personal and professional use. As a leader in creativity and productivity products, Wondershare has received prestigious awards from organizations such as The Shorty Awards, G2, and GetApp. At Wondershare, the mission is to empower individuals to pursue their passions and build a more creative world. With over 100 million users across 150 countries, users can access a wide range of software solutions for video editing, PDF editing, data recovery, diagram and mind mapping, and more. 
Media Contact: [email protected] 
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