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NovoBiome and Inserm form new collaboration to simulate human intestinal physiology

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NovoBiome and Inserm form new collaboration to simulate human intestinal physiology

Integration of Inserm’s leading technologies related to human stem cell-derived intestinal epithelial cells and enteric nervous system to NovoBiome’s organoid on a chip platform

Collaboration aims to complete NovoBiome’s disruptive NovoSift® ex-vivo research and discovery platform to analyze the symbiotic relationship between the microbiota and the human intestine

Paris, France – XX February 2022: NovoBiome (“the Company”), a drug discovery company developing breakthrough Live Biotherapeutics Products (LBPs)1 targeting the microbiome-gut-liver axis, announces today that it has signed a new collaboration with the French National Institute of Health and Medical Research (Inserm), a scientific and technological institute which operates under the joint authority of the French Ministries of Health and Research.

The collaboration will see the development of an innovative intestinal organoid on a chip technology that will complete the functionality of NovoBiome’s disruptive NovoSift® platform, an ex-vivo research and discovery platform to analyze the symbiotic relationship between the microbiota and the human intestine. The collaborative agreement has been negotiated and signed by Inserm Transfert, the private subsidiary of Inserm, on behalf of Inserm and Nantes University.

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NovoSift® not only aims to emulate the complexity of the interactions between the epithelium and the intestinal microbiota, but also to take into account the relationships with the enteric nervous system and the immune system. The Joint Research Unit Inserm TENS (U1235 Inserm/Nantes University) has developed a recognized expertise in the field of human intestinal stem cell biology and in the interactions and cellular functions between the epithelium, the enteric nervous system and the microbiota.

This new collaboration will allow to scale up NovoBiome’s ambition to have a robust and dynamic human relevant model to evaluate the mechanisms at work after the oral administration of a food, a drug or a LBP1 aiming to modulate the intestinal microbiota. Embedded in the robotic high-throughput functional metagenomics units of MetaGenoPolis (French National Research Institute for Agriculture, Food and Environment – INRAE), and associated with NovoBiome’s artificial intelligence algorithm, this technology will also enable NovoBiome to combine multi-OMICS and state of the art live imaging analysis to cover all fields of research and development.

Pierre-Yves Mousset, Chief Executive Officer of NovoBiome, said: “The implications of understanding the host-microbiota relationships are considerable in human health. However, this major part of physiology is currently a “black box” that the exceptional cooperation between NovoBiome and two French academic structures of excellence, Inserm and INRAE, will seek to decipher. We are extremely proud of the trust placed in us and are particularly eager to see the first results.”

“Working in close partnership with NovoBiome represents a unique opportunity to accelerate and foster the transfer of discoveries on health beneficial effects of the gut microbiota from the lab to the benefit of patients and of the overall general population.” commented Michel Neunlist, Director of the TENS unit at Inserm.

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About NovoBiome

NovoBiome is a biotech company developing Live Biotherapeutics Products, a novel and emerging class of drugs, defined by the EMA as medicinal products containing living micro-organisms such as bacteria or yeasts, which have a positive influence on the health and physiology of the host. NovoBiome is developing a proprietary platform, NovoSift®, that rationally identifies Live Biotherapeutics based on a deep understanding of functions and mechanisms.

For more information, please visit: www.novobiome.eu

About Inserm / TENS

TENS (The Enteric Nervous System in Gut and Brain diseases) is a research laboratory in translational Neurogastroenterology labelled by Inserm and Nantes University. TENS aims to understand the role of the enteric nervous system (ENS) in gastrointestinal dysfunctions observed during chronic gut (IBD) and brain diseases (neurodevelopmental – neurodegenerative – neurotraumatic). Combining multi-omic and imaging techniques as well as organoids based approaches, TENS aims at identifying defects in the interactions between the gut microbiota, intestinal epithelial cells and the ENS as a causal factor responsible for GI dysfunctions in diseases of interest and also as a source of novel microbiota based therapeutical approaches.

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About Inserm

Founded in 1964, the French National Institute of Health and Medical Research (Inserm) is a public science and technology institute, jointly supervised by the French Ministry of National Education, Higher Education and Research, and the Ministry of Social Affairs, Health and Women’s Rights. Inserm is the only French public research institute to focus entirely on human health and positions itself on the pathway from research laboratory to the bed of the patient. The mission of its scientists is to study all diseases, from the most common to the rarest. www.inserm.fr

About Inserm Transfert

Inserm Transfert, the private subsidiary of the French National Institute of the Health and Medical Research (Inserm), is responsible for value creation of innovations of Inserm and its academic partners in human health and promotes long-term technology transfers in line with international best practices. Inserm Transfert SA was founded in 2000, and manages, under a Public Service Management Contract (Délégation de Service Public), the entire promotion and transfer of knowledge emerging from the Inserm research laboratories to the industrial world, from invention disclosure to industrial partnerships and startups incorporation. Inserm Transfert also offers services relating to setting up and managing national, European and international projects, as well as supporting the technology transfer of clinical research and health data/databases. In 2009, Inserm Transfert and Inserm established an investment fund to finance proofs of concept. In 2005, Inserm Transfert Initiative, a dedicated seed money fund for life sciences, was created. Since 2017 a pathway for pre-entrepreneurship supports researchers/inventors who aspire to become involved in entrepreneurship. www.inserm-transfert.com

For more information, please visit: www.inserm-tens.com and www.inserm.fr

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Contacts

NovoBiome
Pierre-Yves Mousset, Chief Executive Officer
+33 (0) 616 310 400
[email protected]

INRAeTransfert
Anne-Sophie Alvarez, Microbiome Communication Manager
[email protected]

Inserm Transfert
Ingrid Hargot, Communication Manager
[email protected]

Consilium Strategic Communications
Amber Fennell, Suki Virji, Genevieve Wilson
+44 (0) 203 709 5000
[email protected]

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1 LBPs are medicinal products containing living micro-organisms such as bacteria or yeasts, which have a positive influence on the health and physiology of the host. Source: Ph. Eur. Monograph 3053 (EDQM, 2019)

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Artificial Intelligence

More than 150,000 money laundering accounts detected in APAC

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Region sees 108% increase in voice scams as fraudsters continue shift to mobile
MELBOURNE, Australia and MUMBAI, India, June 25, 2024 /PRNewswire/ — A new financial crime report out today details how criminal organizations in the APAC region now outsource the laundering of money stolen via scams to international syndicates specializing in this cleaning. BioCatch identified and helped APAC banks shut down more than 150,000 money mule accounts in 2023 and estimates exponentially more such accounts in use across the region.

“Where there are scams, there are mules,” BioCatch Director of Global Fraud Intelligence Tom Peacock said. “Criminal organizations use these mule accounts as intermediate stops between the victim’s bank account and the final account from which they plan to withdraw their stolen money. The mules we’ve identified almost certainly represent a tiny fraction of those actively laundering money in the region, with more cropping up every day. Financial institutions in APAC and around the world must do more to identify these mules, hamper their ability to open new accounts, and identify those legitimate accounts money launderers succeed in turning from good to bad.”
In this latest edition of its Digital Banking Fraud Trends in APAC report, BioCatch – which identifies and prevents fraud and financial crime in real time by analyzing as many as 3,000 different physical behavior patterns (mouse movements and typing speed, for example) and cognitive signals (hesitation, segmented typing, etc.) in search of anomalies – points to mobile malware as the greatest threat to banks in Southeast Asia in 2024.
“Whether through SMS-mining or illegal loan apps, we’ve seen an explosion in Android-based malware in the region,” Peacock said. “Malware developers continue to innovate, circumventing bank and Google Play Store defenses to harvest what they need from mobile devices to access digital banking accounts and then transfer away the victim’s funds to a money mule.”
There is reason for hope in fighting fraud in APAC, however. In Australia, the number of reported scam cases grew by 13% in 2023, but scam losses declined by $90 million.
“Nine out of the 10 largest Australian banks employ BioCatch solutions to protect their customers from fraud and financial crime by analyzing the behavior of the user behind every online banking session,” BioCatch APAC Vice President Richard Booth said. “Already in 2024, we see massive progress: Money lost to fraud in the country declined by 48% in the first quarter of this year compared to Q1 of 2023. It’s difficult to reach any conclusion other than that BioCatch has left Australian digital-banking customers far safer from fraud than they were before.”
Other key findings:
No desktop or laptop needed: BioCatch found as much as 70% of all reported frauds in APAC originated from mobile apps in 2023, an increase of 17% from the year before.Scams are everywhere: Across the region, the number of reported voice scams increased by 108% in 2023.Australia bucking all trends: In addition to seeing fraud losses actually decline, the nation also saw fewer fraud cases involving malware or Remote Administration Tools (RATs) in 2023 than it did in 2022.Click here to access BioCatch’s complete 2024 Digital Banking Fraud Trends in APAC report.
About BioCatch:BioCatch stands at the forefront of digital fraud detection, pioneering behavioral biometric intelligence grounded in advanced cognitive science and machine learning. BioCatch analyzes thousands of user interactions to support a digital banking environment where identity, trust, and ease coexist. Today, more than 30 of the world’s largest 100 banks and 196 total financial institutions rely on BioCatch Connect™ to combat fraud, facilitate digital transformation, and grow customer relationships. BioCatch’s Client Innovation Board – an industry-led initiative featuring American Express, Barclays, Citi Ventures, HSBC, and National Australia Bank – collaborates to pioneer creative and innovative ways to leverage customer relationships for fraud prevention. With more than a decade of data analysis, 92 registered patents, and unmatched expertise, BioCatch continues to lead innovation to address future challenges. For more information, please visit www.biocatch.com.
Media contact:Jay [email protected]
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Puyi Fund, Managed by Highest Performances Holdings Inc., Surpasses RMB 24.0 Billion in Assets under Advice, Showing Promising Start to Strategic Transformation

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GUANGZHOU, China, June 25, 2024 /PRNewswire/ — Highest Performances Holdings Inc. (“HPH” or the Group, NASDAQ: HPH), announces that its Puyi Fund’s assets under advice for its asset allocation services reached RMB 24.7 billion as of June 21, 2024, reflecting a remarkable year-on-year growth of 188%. This substantial increase in scale showcases significant growth for the fund.

This accomplishment is primarily attributed to the Puyi Fund’s service philosophy, “long-term commitment to clients and clients’ long-term benefits,” introduced in 2023, as well as the ongoing efforts of the Company in adjusting its product strategy and embracing digital transformation. On one hand, the Company implemented a comprehensive family wealth management account system, redirecting its flagship products towards fixed-income funds and fund portfolios to enhance clients’ perception of wealth acquisition. On the other hand, the Company has elevated its overall service standard through digital transformation, greatly improving the client’s investment experience.
Transforming Product Strategy to Maximize Client Returns
In relation to product strategy transformation, Puyi Fund offers investors a comprehensive solution for managing their family wealth through a scientific approach. This solution guides investors in allocating their investment assets across three types of accounts: Flexible Withdrawal Accounts, Stable Appreciation Accounts, and High-Yield Pursuit Accounts. By considering various market conditions and cycles, investors can make informed decisions on how to distribute their funds among these accounts through a scientific approach for achieving risk mitigation, consistent asset growth, and long-term sustainable investment returns.
Taking into account the prevailing market conditions in China, Puyi Fund advises investors to allocate 25% to 90% of their funds to Stable Appreciation Accounts, depending on their risk tolerance. These accounts primarily involve investing in fixed-income funds, providing investors with consistent and reliable expected returns. By employing the stable appreciation strategy, Puyi Fund aims to restore investors’ confidence in the market, leading to increased trust and recognition. Consequently, Puyi Fund has experienced a period of rapid growth and positive development.
An analysis of data from the Chinese mutual fund market highlights the alignment of Puyi Fund’s client-centric product strategy transformation with market demands. According to Wind data, the market value of the Chinese mutual fund market stood at RMB 25.45 trillion at the end of 2021. By the end of May 2024, this amount grew to RMB 29.09 trillion, representing an increase of RMB 3.64 trillion or 14.30%. The value of equity and hybrid funds, however, experienced a decline from RMB 8.54 trillion to RMB 6.34 trillion, marking a decrease of RMB 2.21 trillion. In contrast, bond funds and money market funds collectively witnessed a significant increase of RMB 5.69 trillion. These market trends suggest that Chinese fund investors are shifting their risk preferences towards lower-risk and higher-certainty assets. Puyi Fund’s strategic transformation is well-positioned to take advantage of this evolving trend.
Enhancing Digital Service Innovation with a Focus on Client Service
In its digital transformation efforts, Puyi Fund places a strong emphasis on “client-centricity” and “service excellence”. By harnessing the power of big data, algorithm mining, and the Sensor Intelligent System, Puyi Fund establishes personalized service scenarios tailored to the unique needs of thousands of individuals. Through meticulous operations that cover the full client lifecycle, Puyi Fund offers full-scope online transactions for both public and private fund clients, establishing a distinctive digital competitive advantage. As of June 2024, the year-to-date client retention rate for fund advisory services stands at 75%, significantly enhancing the likelihood of investment profitability and returns for clients. This success enables clients to truly appreciate the value of advisory services and the time invested in their investments.
Furthermore, Puyi Fund has made continuous advancements in its intelligent client service system, leveraging digital platforms to offer investors comprehensive and efficient services. As of June 2024, the intelligent client service has catered to the needs of approximately 250,000 investors, providing 7*24 services, with a problem resolution rate surpassing 90%. Moreover, Puyi Fund complements intelligent client service with human support, resulting in a client satisfaction rate of 99%. This approach guarantees that investors receive timely and effective assistance whenever required.
Optimizing Trust-Based Communication Channels with Clients
Puyi Fund’s capability to swiftly establish client trust is attributable to its distinctive offline service channels. Unlike other third-party fund sales institutions that heavily rely on online platforms, Puyi Fund provides face-to-face, one-on-one services through offline channels. This approach is especially valuable in navigating complex investment environments, effectively calming investor emotions, enabling them to stay composed and gain a proper understanding of products, ultimately making well-informed investment decisions. Since 2024, Puyi Fund’s research and advisory team has released 28 specialized research reports and organized 19 online client exchanges, along with 35 offline client events, in response to market dynamics and client needs. These initiatives have effectively addressed investors’ concerns and enhanced their confidence.
It is worth mentioning that Puyi Fund’s institutional business has experienced remarkable growth this year, particularly in attracting clients from prominent financial institutions including banks, wealth management subsidiaries, and insurance companies. To cater specifically to institutional investors, Puyi Fund has developed an intelligent over-the-counter fund trading system called “Web-based Institution Master system”. This system provides institutional investors with a wide range of product portfolios, a comprehensive investment research system, and personalized trading experiences. As a result, it comprehensively improves the service quality and efficiency for institutional clients.
As of June 21, Puyi Fund established partnerships with 117 mutual fund companies, including the top 20 fund managers in terms of size, providing access to nearly 11,000 public funds and implementing over 20 customized advisory strategies. In the private fund sector, Puyi Fund has selected over 30 fund managers from the entire market. Of these, 38% manage assets over RMB 10 billion, while 29% manage assets between RMB 5 billion and RMB 10 billion. This selection covers a wide range of mainstream strategy products in the market, catering to the allocation needs of various types of investors.
It is reported that Puyi Fund, an independent third-party fund sales institution holding a fund sales business license issued by the China Securities Regulatory Commission, operates as a subsidiary of Highest Performances Holdings Inc. (NASDAQ: HPH). Embracing the concept of buyer advisor, Puyi Fund is dedicated to delivering comprehensive family financial asset allocation services to individual investors and diversified financial services to institutional investors through its financial technology service platform. With exceptional resource integration capabilities, professional research expertise, and high-quality client service, Puyi Fund strives to cultivate long-term partnerships with clients, catering to their personalized asset allocation needs in various scenarios while assisting a broader range of investors in achieving sustainable long-term returns. As of December 31, 2023, the accumulated assets under Puyi Fund’s allocation advisory services surpassed RMB 75.1 billion, exhibiting a compound annual growth rate of 128.8% from 2015 to 2023.
About Highest Performances Holdings Inc. (NASDAQ: HPH)
HPH was founded in 2010 with the aim of becoming a top provider of smart home and enterprise services. Its mission is to improve the quality of life for families worldwide, focusing on two main driving forces: “technological intelligence” and “capital investments.”HPH has a global strategic perspective and identifies high-quality enterprises with global potential for investment and operations. Its areas of focus include asset allocation, education and study tours, cultural tours, sports events, healthcare and elderly care and family governance.
HPH currently holds controlling interests in two leading financial service providers in China, namely Fanhua Inc., a technology-driven platform, and Fanhua Puyi Fund Distribution Co., Ltd., an independent wealth management service provider.
Highest Performances Holdings Inc., formerly known as Puyi Inc., was renamed on March 13, 2024 to reflect its strategic transformation.

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ID Verify Now Available for Yardi Breeze Premier Clients

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Leading software provider introduces biometric technology as the first step in the resident screening process
SANTA BARBARA, Calif.  , June 25, 2024 /PRNewswire/ — In response to the increase in fraudulent applications in multifamily rentals, Yardi® has launched ID Verify for Yardi Breeze® Premier clients in the United States and Canada. The use of biometrics is emerging as a standard screening practice in North America, as it allows property managers to confirm applicant identities before scheduling a tour.

Employing ID Verify as the initial step in the resident screening process provides Breeze Premier clients with a higher level of fraud prevention. Prospective renters simply upload a selfie and a photo of a government-issued identification document to the cloud. Then ID Verify detects fake IDs and validates real identities, ensuring a secure and reliable screening process. The new technology can also manage resident, visitor and vendor access, enhancing community security.
When paired with ScreeningWorks® Pro in the United States or Yardi® Resident Screening in Canada, property managers centralize resident screening data with their property data. This single source of truth provides multifamily businesses with a deeper understanding of who they’re renting to, ensuring greater confidence and quality in resident selection.
“Rising fraud increases the risks of bad debt,” said Peter Altobelli, vice president and general manager of Yardi Canada Ltd.” However, we’re optimistic that ID Verify will safeguard the future of the multifamily market when implemented as the first step in the resident screening process.”
Book a demo to learn more about ID Verify and how it will benefit your property management business.
About Yardi
Celebrating its 40-year anniversary in 2024, Yardi® develops industry-leading software for all types and sizes of real estate companies across the world. With over 9,000 employees, Yardi is working with our clients to drive significant innovation in the real estate industry. For more information on how Yardi is Energized for Tomorrow, visit yardi.com.
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