Artificial Intelligence
Sinaptica Therapeutics Announces Publication of Positive Results from Phase II Trial Evaluating the Potential of Precision-Delivered Noninvasive Neurostimulation Treatment for Mild-to-Moderate Alzheimer’s Disease
Phase II sham-controlled randomized trial met its primary endpoint with statistical significance; treatment slowed cognitive decline by 82% over 6 months in the treated population compared to sham with no safety issues
Key secondary measures of cognitive function also reached statistical significance, including a 108% difference in function as measured by ADCS-ADL
Trial results published in the peer-reviewed neurology journal Brain
Company was formed to develop SinaptiStim™ – AD System based on the hypothesis tested in the Phase II trial and plans to evaluate its investigational device in a pivotal trial beginning in 2023
CAMBRIDGE, Mass., Oct. 25, 2022 (GLOBE NEWSWIRE) — Sinaptica Therapeutics, Inc., a clinical-stage company leading the development of a new class of personalized electromagnetic therapeutics to treat neurodegenerative diseases, today announced the publication of a Phase II trial conducted independently under the leadership of its co-founders, which yielded positive results demonstrating that precision-delivered noninvasive brain stimulation has the potential to slow the progression of cognitive and functional decline in patients with mild-to-moderate dementia due to Alzheimer’s disease. The findings have been published in the peer-reviewed neurology journal Brain.
Fifty patients were enrolled in the Phase II randomized, double-blind, sham-controlled trial. The patients underwent a novel diagnostic assessment using both transcranial magnetic stimulation (TMS) and electroencephalogram (EEG) to personalize key treatment parameters to each patient. The trial included a 24-week treatment period, with an initial 2-week intensive course during which repetitive transcranial magnetic stimulation (rTMS) or sham was applied over the precuneus daily (five times per week), followed by a 22-week maintenance phase during which the same stimulation was applied weekly. rTMS was given as an add-on to standard treatment with acetylcholinesterase inhibitors.
The primary outcome measure was the change at 24 weeks from baseline of the Clinical Dementia Rating Scale–Sum of Boxes (CDR-SB) score (scores range from 0 to 18, with higher scores indicating worse cognition and daily function). Over the course of the trial, patients in the treatment group showed a stable performance while patients in the sham (placebo) group showed a general worsening of cognitive performance. Specifically, the precision-delivered rTMS treatment slowed cognitive decline, compared to the sham intervention, by 82% at 6 months, representing a treatment difference in the CDR-SB score of 1.3 points (p=0.009). Treatment was well tolerated, and no serious adverse events were observed in patients treated with rTMS for 6 months.
“We are very encouraged by the statistically significant and clinically meaningful results of our precision-delivered noninvasive neurostimulation approach in patients with mild-to-moderate Alzheimer’s disease,” said lead investigator Giacomo Koch, MD, PhD, co-founder of Sinaptica Therapeutics, Full Professor of Physiology at University of Ferrara, Italy and Director, Non-invasive Brain Stimulation Laboratory, at Santa Lucia Foundation, IRCCS in Rome, Italy, which is where the Phase II trial was conducted. “The results are particularly notable because they were achieved in patients already showing symptoms of mild-to-moderate dementia, in which cognitive decline progresses more rapidly and is less responsive to drug interventions. As one of the largest trials of brain stimulation ever conducted in Alzheimer’s disease resulting in a therapeutic benefit and the first to use a precision-delivered protocol targeting the precuneus, we have validated the potential of our novel approach to be a new therapeutic tool in the treatment of Alzheimer’s disease and potentially other neurodegenerative diseases.”
Patients in the treatment group also showed better performance compared to the sham group in three key secondary outcome measures, which reached statistical significance. In the Alzheimer’s Disease Cooperative Study–Activities of Daily Living (ADCS-ADL) scale, treatment showed an improvement in cognitive function compared to sham with an estimated mean change in ADCS-ADL scores of -0.7 for the treatment group and 7.5 for the sham group, demonstrating a 108% difference between the treatment and sham groups at 6 months. The Alzheimer’s Disease Assessment Scale–Cognitive Subscale (ADAS-Cog) and Mini-Mental State Examination (MMSE) also demonstrated a slowing of functional decline, with an estimated mean change in ADAS-Cog score of -0.67 for the treatment group and -4.2 for the sham group and an estimated mean change in MMSE score of 0.30 for the treatment group and 1.8 for the sham group.
In addition, neurophysiological results showed that precuneus cortical excitability remained unchanged after 6 months in the treatment group, whereas it was significantly reduced in the sham group as a reflection of pathological decline of brain activity, suggesting a neuroprotective treatment effect.
“Alzheimer’s disease patients develop alterations to the Default Mode Network, or DMN, a key network responsible for episodic memory for which the precuneus is a key region,” said study investigator Emiliano Santarnecchi, PhD, co-founder of Sinaptica Therapeutics, Associate Professor of Radiology at Harvard Medical School, as well as Director, Precision Neuroscience & Neuromodulation Program and Director, Network Control Laboratory, at Massachusetts General Hospital in Boston, MA. “In this Phase II trial, we have shown that the DMN can be targeted by precision-delivered noninvasive therapeutic interventions that utilize electromagnetic brain stimulation to improve plasticity and stabilize network connectivity. We believe this is an important development with the potential to address the staggering unmet need in the treatment of Alzheimer’s disease and warrants further evaluation.”
Dr. Koch and Dr. Santarnecchi founded Sinaptica Therapeutics to further develop, test, and translate the groundbreaking science into real-world therapeutic solutions, including the development of an investigational precision-delivered noninvasive neurostimulation device for treating mild-to-moderate Alzheimer’s disease.
“Sinaptica Therapeutics is pioneering a new class of electromagnetic therapeutics that integrate AI-derived protocols, brain modeling and network targeting to achieve a personalized and precision-delivered approach to slowing the progression of cognitive and functional decline in Alzheimer’s disease,” said Rich Macary, President of Sinaptica Therapeutics. “These unprecedented peer-reviewed clinical results demonstrate the potential for this new class of personalized electromagnetic therapeutics to treat cognitive and functional decline safely and noninvasively in Alzheimer’s disease patients. We look forward to confirming the significant Phase II results and obtaining additional clinical data in a larger, multi-center, pivotal trial using our patent-pending investigational SinaptiStim™ – AD System, which has been granted Breakthrough Device Designation by the U.S. Food and Drug Administration.”
About Sinaptica Therapeutics
Sinaptica Therapeutics is a clinical-stage electromagnetic therapeutics company pioneering a personalized noninvasive brain stimulation approach with the potential to revolutionize the treatment of Alzheimer’s disease (AD). The company’s personalized, noninvasive brain stimulation platform is underpinned by significant clinical trial results showing an unprecedented reduction in cognitive decline and improved function in mild-to-moderate Alzheimer’s disease patients. The investigational SinaptiStim™ – AD System integrates electromagnetic stimulation of the brain with powerful proprietary artificial intelligence-derived protocols, brain modeling, and network targeting to create a personalized and precision-delivered therapeutic approach. The company plans to advance this promising science with a pivotal, randomized, controlled clinical trial. It seeks to create a new, more efficient treatment paradigm for the staggering unmet need and burden of AD, as well as other neurodegenerative disorders. The company has received Breakthrough Device Designation from the U.S. Food and Drug Administration for the patent-pending SinaptiStim™ – AD System. For more information, please visit www.sinapticatx.com.
The SinaptiStim™ – AD System is for investigational use only. It has not been approved by the U.S. Food and Drug Administration and is not available for commercial sale.
Media Contact
Tony Plohoros
6 Degrees
[email protected]
Business Contact
Rich Macary
Sinaptica Therapeutics, Inc.
[email protected]
STOCKHOLM, Oct. 11, 2024 /PRNewswire/ — The following representatives of ASSA ABLOY AB’s shareholders will be members of the Nomination Committee for the 2025 Annual General Meeting:
– Johan Menckel, Investment AB Latour, Chairman of the Nomination Committee
– Mikael Ekdahl, Melker Schörling AB
– Marianne Nilsson, Swedbank Robur Fonder
– Yvonne Sörberg, Handelsbanken Fonder
– Carina Silberg, Alecta
The Chairman of the Board, Johan Hjertonsson, has been co-opted to the Nomination Committee.
The Nomination Committee shall prepare proposals for the Annual General Meeting in 2025 regarding the election of Chairman of the General Meeting, members of the Board of Directors, Chairman of the Board, Vice Chairman of the Board, auditor, fees for the members of the Board including division between the Chairman, the Vice Chairman and the other Board members as well as fees for committee work, fees to the company’s auditor and, if necessary, changes to the instructions for the Nomination Committee.
The Annual General Meeting will be held on 23 April 2025, in Stockholm, Sweden.
Shareholders who wish to submit proposals to the Nomination Committee should send an email to [email protected].
For more information, please contact:Nico Delvaux, President and CEO, tel. no: +46 8 506 485 82Erik Pieder, CFO and Executive Vice President, tel. no: +46 8 506 485 72 Björn Tibell, Head of Investor Relations, tel. no: +46 70 275 67 68
About ASSA ABLOY
The ASSA ABLOY Group is the global leader in access solutions. The Group operates worldwide with 61,000 employees and sales of SEK 141 billion. The Group has leading positions in areas such as efficient door openings, trusted identities and entrance automation. ASSA ABLOY’s innovations enable safe, secure and convenient access to physical and digital places. Every day, we help billions of people experience a more open world.
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Artificial Intelligence
AI in Social Media Market worth $10.33 billion by 2029- Exclusive Report by MarketsandMarkets™
DELRAY BEACH, Fla., Oct. 11, 2024 /PRNewswire/ — The AI in Social Media Market is projected to grow from USD 2.20 billion in 2024 to USD 10.33 billion by 2029, at a compound annual growth rate (CAGR) of 36.2% during the forecast period, according to a new report by MarketsandMarkets™. The market is expected to grow due to the rise in the need for more personalized user experiences, optimized advertising, and automated customer service.
Browse in-depth TOC on “AI in Social Media Market”
315 – Tables 63 – Figures320 – Pages
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Scope of the Report
Report Metrics
Details
Market size available for years
2019-2029
Base year considered
2023
Forecast period
2024-2029
Forecast units
USD (billion)
Segments Covered
Product type, Use case, End user, and Region
Geographics covered
North America, Europe, Asia Pacific, Middle East & Africa, Latin America
Companies covered
Major vendors in the global AI in Social Media Market are Google (US), Meta (US), IBM (US), Sprout Social (US), Sprinklr (US), AWS (US), LivePerson (US), HubSpot (US), Microsoft (US), Adobe (US), Baidu (China), OpenAI (US), Hootsuite (US), Qualtrics (US), Brandwatch (UK), Converseon (US), Meltwater (US), Quid (US), Digimind (France), CreatorIQ (US), Aspire.io (US), Lately.AI (US), SocialPilot (US), Copy.ai (US), Flick (UK), Dash Hudson (US), Jasper (US), Upfluence (US), Ocoya (Lithuania), Upgrow (US), StoryChief (Belgium), Genius.AI (UAE), ContentStudio (US), Emplifi (US), Lumen5 (US), Buffer (US), Narrato (India), Mentionlytics (UK), Kapwing (US), Predis.AI (India), Pictory (US), Midjourney (US), and Synthesia (UK).
The major factors driving the market growth of AI in Social Media Market include the introduction of AI-powered deepfake detection in social media to identify and flag altered content. Social platforms are increasingly relying on advanced AI algorithms to detect and flag manipulated videos, images, and audio, addressing growing concerns about misinformation, fraud, and digital deception. Growth in Gen AI-based content creation tools enables brands to create captivating and unique content. These tools empower brands to effortlessly create captivating, unique content at scale, allowing personalized engagement with audiences. The rising demand for highly personalized content and recommendations tailored to user preferences and behavior are shaping the social media market. This personalization boosts user satisfaction, fosters stronger engagement, and increases time spent on platforms, benefiting users and advertisers. Improved collaboration between influencers and brands is boosting the effectiveness of influencer marketing campaigns with AI. AI tools help brands and influencers to better understand the audiences by analyzing data like preferences, behaviors, and trends. This helps both brands and influencers grow their reach and engagement which makes influencer marketing campaigns successful.
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Advent of Gen AI-based content creation tools enables brands to create captivating and unique content.
The rise of gen AI-based content creation tools has transformed social media by empowering brands to create unique content. These tools are powered by advanced language models, enable automated text generation, images, and videos that cover target audiences, and maintain a dynamic presence on platforms. The utilization of gen AI across sectors such as entertainment, healthcare, and marketing agencies is transforming content creation and customer engagement. Gen AI also simplifies content production workflow, reducing time and cost related to traditional content creation methods. Global tech giants are investing heavily in AI technologies to improve user experience, enhance advertising effectiveness, and gain competitive advantages in the AI in social media market.
By Product type, the influencer marketing segment registers for the fastest growing market during the forecast period.
By automating and optimizing influencer marketing, AI social media tools enable brands to make data-driven decisions, reach relevant audiences, and ensure their campaigns are more effective and cost-efficient. AI-based social media tools in influencer marketing assist brands in detecting fraudulent influencers, which can improve the ROI, increase sales, and improve the brand’s reputation. For instance, AI content tools like Lumen5, Canva, Jasper, and Midjourney are major tools for improving influencer marketing strategies by crafting high-quality content.
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By region, Asia Pacific to register the highest CAGR market during the forecast period.
Asia Pacific is a rapidly growing region for AI in social media, compelled by high mobile and internet penetration rates and a young, tech-savvy population. Countries like China, India, Japan, and South Korea are leading the adoption, with social media platforms being central to the region’s social media ecosystem. With the vast amount of content generated in diverse languages, AI in social media is used for content moderation, language translation, and understanding user-generated content, specifically across China and India.
Top Key Companies in AI in Social Media Market:
Some major players in the AI in Social Media Market include Google (US), Meta (US), IBM (US), Sprout Social (US), Sprinklr (US), AWS (US), LivePerson (US), HubSpot (US), Microsoft (US), Adobe (US), Baidu (China), OpenAI (US), Hootsuite (US), Qualtrics (US), Brandwatch (UK), Converseon (US), Meltwater (US), Quid (US), Digimind (France), CreatorIQ (US), Aspire.io (US), Lately.AI (US), SocialPilot (US), Copy.ai (US), Flick (UK), Dash Hudson (US), Jasper (US), Upfluence (US), Ocoya (Lithuania), Upgrow (US), StoryChief (Belgium), Genius.AI (UAE), ContentStudio (US), Emplifi (US), Lumen5 (US), Buffer (US), Narrato (India), Mentionlytics (UK), Kapwing (US), Predis.AI (India), Pictory (US), Midjourney (US), and Synthesia (UK).
Browse Adjacent Markets: Artificial Intelligence (AI) Market Research Reports & Consulting
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Artificial Intelligence
NTT DATA signs agreement to acquire Aoop and will become a leader in ServiceNow solutions in Latin America
BIELEFELD, Germany and SÃO PAULO, Oct. 11, 2024 /PRNewswire/ — NTT DATA Business Solutions AG, a global unit of NTT DATA, announces that the agreement for the acquisition of Aoop, a leading ServiceNow implementation company in Brazil, has been signed. The terms of the acquisition have been finalized between the companies and will be completed following approval from the Administrative Council for Economic Defense (CADE). Founded in 2017, Aoop supports customers across various industries and is a specialist in the acceleration of automated digital strategies. With Aoop, NTT DATA will expand its operations in the Latin American ServiceNow solutions market, complementing a recent acquisition in the UK focused on strengthening this offering in Europe and the United States.
“With the acquisition of Aoop, we significantly increase our competitive strength in Brazil by offering both SAP and ServiceNow solutions, positioning us alongside market leaders,” says Norbert Rotter, CEO, NTT DATA Business Solutions. “This move will not only secure us a leading position in the fast-growing ServiceNow ecosystem but will also integrates a company with a strong market presence and solid financials to NTT DATA. It will be a significant step in driving our strategic objectives, strengthening our partnership with ServiceNow and our commitment to establishing a Center of Excellence in the region.”
Ricardo Fachin, Managing Director of NTT DATA Business Solutions Brazil adds: “The acquisition of Aoop will solidify our leading position in the Brazilian market. It will enhance synergies with our other Latin American and U.S. operations, accelerating our regional growth. As part of ServiceNow’s global strategy, Brazil will become a significant shoring center for the group. Aoop’s comprehensive portfolio, covering all ServiceNow verticals, will benefit all NTT DATA customers.”
With a strategy focused on driving the future of organizations and providing full lifecycle services, Aoop has completed around 2,500 digital transformation projects and has over 300 professionals certified on ServiceNow solutions. This expertise has led the company to become a ServiceNow Elite Partner in record time. The continuous commitment to excellence and the delivery of innovative solutions have established Aoop as a market reference, integrating intelligent efficiency throughout the entire production chain.
“Aoop leads the ServiceNow market in Brazil. Our integration with NTT DATA Business Solutions will allow us to further expand our solution offerings to existing customers, access new opportunities for joint solutions with SAP customers and accelerate our international expansion,” says Luiz Cesar Baptistella, CEO and founder of Aoop.
The acquisition of Aoop will add 120 customers to the portfolio of NTT DATA Business Solutions, which has been operating in Brazil for 25 years. Aoop will become a subsidiary of NTT DATA Business Solutions – Servicos de Tecnologia Ltda. in Brazil and will operate as an independent company after the acquisition, using the brand name “Aoop, an NTT DATA Company”.
For more information visit nttdata-solutions.com.
About NTT DATA Business Solutions
NTT DATA Business Solutions is a leading global IT service provider focused on SAP with a powerful ecosystem of partners. With more than 35 years of in-depth experience, we enable companies worldwide to become Intelligent Enterprises. We deliver end-to-end solutions that accelerate sustainable growth and success – from strategic consulting and implementation to managed services and beyond. As a global strategic SAP partner, we drive innovation and leverage the latest technologies to support our customers individually and across all industries. Our more than 15,300 dedicated employees in over 30 countries work passionately every day to make it happen.
NTT DATA Business Solutions is part of NTT DATA, a $30+ billion trusted global innovator of business and technology services headquartered in Tokyo. As One NTT DATA we serve 75% of the Fortune Global 100 and are committed to helping customers innovate, optimize and transform for long-term success. NTT DATA is part of NTT Group.
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T: +55 41 988658826
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