- Prevalence of esophageal and gastric varices in patients with compensated NASH cirrhosis and portal hypertension
- Biochemical and imaging profiles in 271 patients with compensated NASH cirrhosis and portal hypertension
- Hepatic Expression of Galectin-3, a Pro-fibrotic and Pro-inflammatory Marker
- Clinical utility of the ELF score in compensated NASH cirrhotic patients with portal hypertension
- Histological correlation with portal pressures and varices in NASH cirrhosis using quantitative digital pathology
NORCROSS, Ga., Nov. 01, 2022 (GLOBE NEWSWIRE) — Galectin Therapeutics Inc. (NASDAQ:GALT), the leading developer of therapeutics that target galectin-3, today announced that it will share five scientific presentations at The Liver Meeting™ 2022, hosted by the American Association for the Study of Liver Diseases (AASLD), to be held November 4-8, 2022, in Washington, D.C.
“For the sake of our patients, we need to bring more attention to liver cirrhosis and, particularly, to portal hypertension, a clinically relevant complication of the disease for which no etiologic treatment exists,” said Pol Boudes, M.D., Chief Medical Officer of Galectin Therapeutics. “ Early therapeutic intervention to counteract the process of portal hypertension increases the chance of success, and this is exactly what we are trying to do with our candidate drug Belapectin, a galectin-3 inhibitor. This year at AASLD Liver Meeting, we will share more information on the patient population we are recruiting for our global NAVIGATE phase 2b/3 study; our adjudication process for esophago-gastric endoscopies, an essential element in our objective to demonstrate that belapectin can prevent the development of esophageal varices; and the mechanism of action of the drug. We are also happy to share with the medical community new data regarding a non-invasive test (NIT) and liver histology reading with artificial intelligence (AI) in patients affected by NASH cirrhosis and portal hypertension.”
Abstracts will be available for viewing by attendees on the AASLD website and are also featured in the October supplement to the AASLD journal, Hepatology.
Title: Prevalence of esophageal and gastric varices in patients with compensated non-alcoholic steatohepatitis (NASH) cirrhosis and portal hypertension. Data from the NAVIGATE study
Abstract Number: 2329
Authors: Boudes Pol, Alkhouri Naim, Ladron de Guevara Cetina Laura, Elgouhari Hesham, Mena Edward, Ortiz-Lasanta Grisell, Lawitz Eric, Moore Ann, Borg Brian, Noureddin Mazen, Lucas Kathryn, Vuppalanchi Raj, Reiss Gary, Schiefke Ingolf, Safadi Rifat, Shiffman Mitchell, Behari Jaideep, Patel Chirag, Ben-Ari Ziv, Halegoua-De Marzio Dina, Patel Pankaj, Patel Bhaktasharan, Caldwell Stephen, Ghalib Reem, Kayali Zeid, Vierling John, Williams Alonzo, Aazami Hessam, and Mills-Wilson Marla, for the NAVIGATE study group.
Date: Saturday, November 5, 2022
Time: 1:00 pm – 2:00 pm ET
Title: Biochemical and imaging profiles in 271 patients with compensated NASH cirrhosis and clinically suspected portal hypertension: an ongoing prospective cohort
Abstract Number: 2337
Authors: Boudes P, Alkhouri N, Elgouhari H, Lucas K, Lawitz E, Borg B, Vuppalanchi R, Behari J, Patel C, Noureddin M, Reiss G, Halegoua-De Marzio D, Caldwell S, Ghalib R, Landaverde C, Patel P, Shiffman M, Moore A, Kopaczewski J, Mills-Wilson M, for the NAVIGATE study group
Date: Saturday, November 5, 2022
Time: 1:00 pm – 2:00 pm ET
Title: Hepatic Expression of Galectin-3, a Pro-fibrotic and Pro-inflammatory Marker – An Immunohistochemical Survey
Publication Number: 1407
Authors: Zachary D. Goodman, MD, PhD; Ezra Lowe, PhD; Pol F. Boudes, MD, Inova Health System, Fall Church, VA, USA, Galectin Therapeutics, Norcross, GA, USA
Date: Friday, November 4, 2022
Time: 12:00 pm – 1:00 pm ET
Title: Clinical utility of the ELF score in compensated NASH cirrhotic patients with portal hypertension
Publication Number: 2319
Authors: Boudes PF, Lowe E, Galectin Therapeutics
Date: Saturday, November 5, 2022
Time: 1:00 pm – 2:00 pm ET
Title: Histological correlation with portal pressures and varices in NASH cirrhosis using quantitative digital pathology
Publication Number: 36696
Authors: Mazen Noureddin, Dean Tai, Elaine L. K. Chng, Yayun Ren, Pol Boudes, Harold Shlevin, Stephen A. Harrison, Naga P. Chalasani, Zachary Goodman
Date: Available as ePoster
Belapectin is a complex carbohydrate drug that targets galectin-3, a critical protein in the pathogenesis of NASH and fibrosis. Galectin-3 plays a major role in diseases that involve scarring of organs, including fibrotic disorders of the liver, lung, kidney, heart and vascular system. Belapectin binds to galectin-3 and disrupts its function. Preclinical data in animals have shown that belapectin has robust treatment effects in reversing liver fibrosis and cirrhosis. A Phase 2 study showed belapectin may prevent the development of esophageal varices in NASH cirrhosis, and these results provide the basis for the conduct of the NAVIGATE trial. The NAVIGATE trial (www.NAVIGATEnash.com), titled “A Seamless Adaptive Phase 2b/3, Double-Blind, Randomized, Placebo-controlled Multicenter, International Study Evaluating the Efficacy and Safety of Belapectin (GR-MD-02) for the Prevention of Esophageal Varices in NASH Cirrhosis,” began enrolling patients in June 2020, and is posted on www.clinicaltrials.gov (NCT04365868). Galectin-3 has a significant role in cancer, and the Company has supported a Phase 1b study in combined immunotherapy of belapectin and KEYTRUDA in advanced melanoma and in head and neck cancer. This trial provided a strong rationale for moving forward into a Company-sponsored Phase 2 development program, which the company is exploring.
About the American Association for the Study of Liver Diseases (AASLD)
AASLD is the leading organization of scientists and health care professionals committed to preventing and curing liver disease. AASLD fosters research that leads to improved treatment options for millions of liver disease patients. It also advances the science and practice of hepatology through educational conferences, training programs, professional publications, and partnerships with government agencies and sister societies. AASLD’s annual scientific conference, The Liver Meeting™, is the world’s premier meeting on liver disease, bringing together clinicians, associates, and scientists from around the world to exchange information on the latest research, discuss new developments in liver treatment and transplantation, and network with leading experts in the field of hepatology.
About Galectin Therapeutics
Galectin Therapeutics is dedicated to developing novel therapies to improve the lives of patients with chronic liver disease and cancer. Galectin’s lead drug belapectin (formerly known as GR-MD-02) is a carbohydrate-based drug that inhibits the galectin-3 protein which is directly involved in multiple inflammatory, fibrotic, and malignant diseases, for which it has Fast Track designation by the U.S. Food and Drug Administration for NASH with advanced fibrosis. The lead development program is in non-alcoholic steatohepatitis (NASH) with cirrhosis, the most advanced form of NASH-related fibrosis. This is the most common liver disease and one of the largest drug development opportunities available today. Additional development programs are in treatment of combination immunotherapy for advanced melanoma and other malignancies. Advancement of these additional clinical programs is largely dependent on finding a suitable partner. Galectin seeks to leverage extensive scientific and development expertise as well as established relationships with external sources to achieve cost-effective and efficient development. Additional information is available at www.galectintherapeutics.com.
Forward Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements relate to future events or future financial performance, and use words such as “may,” “estimate,” “could,” “expect” and others. They are based on management’s current expectations and are subject to factors and uncertainties that could cause actual results to differ materially from those described in the statements. These statements include those regarding the hope that Galectin’s development program for belapectin will lead to the first therapy for the treatment of fatty liver disease with cirrhosis and those regarding the hope that our lead compounds will be successful in cancer immunotherapy and in other therapeutic indications. Factors that could cause actual performance to differ materially from those discussed in the forward-looking statements include, among others, that trial endpoints required by the FDA may not be achieved; Galectin may not be successful in developing effective treatments and/or obtaining the requisite approvals for the use of belapectin or any of its other drugs in development; the Company may not be successful in scaling up manufacturing and meeting requirements related to chemistry, manufacturing and control matters; the Company’s current clinical trial and any future clinical studies as modified to meet the requirements of the FDA may not produce positive results in a timely fashion, if at all, and could require larger and longer trials, which would be time consuming and costly; plans regarding development, approval and marketing of any of Galectin’s drugs are subject to change at any time based on the changing needs of the Company as determined by management and regulatory agencies; regardless of the results of any of its development programs, Galectin may be unsuccessful in developing partnerships with other companies or raising additional capital that would allow it to further develop and/or fund any studies or trials. Galectin has incurred operating losses since inception, and its ability to successfully develop and market drugs may be impacted by its ability to manage costs and finance continuing operations. Global factors such as coronavirus may continue to impact NASH patient populations around the globe and slow trial enrollment and prolong the duration of the trial and significantly impact associated costs. For a discussion of additional factors impacting Galectin’s business, see the Company’s Annual Report on Form 10-K for the year ended December 31, 2021, and subsequent filings with the SEC. You should not place undue reliance on forward-looking statements. Although subsequent events may cause its views to change, management disclaims any obligation to update forward-looking statements.
Jack Callicutt, Chief Financial Officer
Galectin Therapeutics and its associated logo is a registered trademark of Galectin Therapeutics Inc. Belapectin is the USAN assigned name for Galectin Therapeutics’ galectin-3 inhibitor GR-MD-02.
Source: Galectin Therapeutics Inc.
Core to Cloud Partners with Cybersecurity Innovator SenseOn to Enable Comprehensive NDR and SIEM Security
New strategic arrangement allows organisations to monitor identity, endpoint, network and cloud-based activity to stop threats immediately.
CIRENCESTER, England, March 1, 2024 /PRNewswire/ — Core to Cloud, a leading provider of cybersecurity services and solutions, is excited to announce a strategic alliance with SenseOn, a renowned threat detection management platform. This collaboration will empower businesses to bolster their advanced NDR and SEIM operations and secure end-to-end platforms.
In today’s integrated digital landscape, businesses rely on various systems and third-party suppliers. The launch of SenseOn’s platform marks a significant leap forward in proactive threat detection and response, offering a comprehensive solution to combat sophisticated cyber threats. Organisations can identify, detect and respond to vulnerabilities in traditional blind spots. Core to Cloud’s partnership with SenseOn aims to address these challenges by offering a comprehensive and efficient solution for managing threat detection and response.
James Cunningham, CEO and co-founder of Core to Cloud, said: “We are excited to announce our partnership with SenseOn, allowing Core to Cloud to bring our clients a more robust and complete threat detection and management solution. With an ever-changing digital landscape, our clients must be able to detect and respond to any threats within their cyber estate. This partnership offers an all-encompassing approach to managing these risks.”
One of the critical features of this partnership is that the platform is built upon a foundation of Artificial Intelligence (AI) and Machine Learning (ML) technologies, meticulously designed to evolve alongside cyber threats. Leveraging its unique Deep Learning, SenseOn’s platform analyses vast and complex datasets, providing real-time threat detection, investigation, and autonomous response capabilities. This innovative approach and Core to Cloud’s cybersecurity expertise enables organisations to proactively address potential threats before they escalate, ensuring robust protection against evolving cyber-attacks.
SenseOn’s platform and Core to Cloud’s know-how empower security teams to navigate the complicated threat landscape efficiently. Intelligent automation streamlines incident response, allowing cybersecurity professionals to focus on strategic initiatives rather than routine tasks.
David Atkinson, CEO and Founder of SenseOn, added: “We are excited to announce a pivotal moment in SenseOn’s journey with establishing a strategic channel partnership with Core to Cloud. This collaboration is more than a partnership; it’s an alliance that leverages the strengths of both companies to propel us towards growth. By combining SenseOn’s consolidated threat detection platform with Core to Cloud’s technical and service expertise, we are poised to deliver a new standard in cybersecurity solutions.”
Moreover, Core to Cloud and SenseOn are committed to ongoing collaboration and continuous improvement. As cybersecurity threats evolve, so do the strategies and tools to counter them. This collaboration is not just a one-time solution; it represents an ongoing commitment to enhancing the cybersecurity landscape for businesses of all sizes. Core to Cloud and SenseOn will continue to work together to develop new features, refine existing tools, and provide unparalleled support to our clients.
Core to Cloud’s partnership with SenseOn signifies a major step forward in cybersecurity. By combining expertise, technology, and a shared commitment to excellence, the two companies are paving the way for businesses to navigate the complex digital landscape confidently. Together, they empower businesses to protect their NDR, SEIM and end-to-end platforms.
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Fire Protection System Market worth $97.2 billion by 2029 – Exclusive Report by MarketsandMarkets™
CHICAGO, March 1, 2024 /PRNewswire/ — The global fire protection system market size is projected to grow from USD 71.6 billion in 2024 to USD 97.2 billion by 2029 at CAGR of 6.3% during the forecast period according to a new report by MarketsandMarkets™. Fire protection systems help prevent fire accidents and damage. These systems reduce the impact of uncontrolled fires, saving lives and property. Fire alarms and detection systems, fire sprinkler systems, and fire suppression systems are among the popular options. Their demand has grown in the last decade, as most countries are committed to safety regulations. These systems are used in many sectors, such as residential, commercial, manufacturing, oil and gas, and energy and power.
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Browse in-depth TOC on “Fire Protection System Market” 194 – Tables72 – Figures284 – Pages
Fire Protection System Market Report Scope:
Market Revenue in 2024
$ 71.6 billion
Estimated Value by 2029
$ 97.2 billion
Poised to grow at a CAGR of 6.3%
Market Size Available for
Value (USD Million/Billion)
Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
By Fire Suppression, Smoke Detector, Heat Detector, Sprinkler, Service, Vertical and Region
North America, Europe, Asia Pacific, and Rest of World
Key Market Challenge
Addressing ever-evolving regulatory requirements
Key Market Opportunities
Increasing government initiatives to upgrade building codes
Key Market Drivers
Surge in residential and commercial infrastructure development
The market for fire detection is expected to grow at a significant CAGR during the forecast period.
Fire detection is a critical part of any building design. They are available for residential, commercial, and industrial use. Fire detectors and control panels (including smoke, heat, and flame detectors) are essential in fire safety. They are specially used in homes for fire detection. Such systems are permanently installed to detect fires at an early stage and quickly inform the relevant emergency service. Fire detection products, such as flame detectors, smoke detectors, and heat detectors, alert the occupants through alarms and trigger automatic fire extinguishers, such as sprinklers. Successful fire prevention and protection depends on the performance of fire detection products. Thus, they are expected to offer accurate and early fire detection. A rise in new construction projects is generating demand for fire detectors due to various mandates pertaining to the compulsory installation of fire protection systems in new buildings.
The manufacturing segment is expected to gain a substantial market share during the forecast period.
Fires in manufacturing plants can be catastrophic due to the presence of large and critical structures. The manufacturing industry faces numerous fire hazards due to flammable materials, electrical equipment, dust accumulation, confined spaces, and chemical reactions. Fire protection systems are crucial in safeguarding lives, preventing property damage, mitigating environmental impact, and ensuring regulatory compliance. These systems are vital in protecting workers, reducing financial losses, and minimizing the risk of environmental pollution associated with fire incidents. The installation of fire protection systems in manufacturing plants is crucial. These products, such as fire suppressors and fire sprinklers, can extinguish fires and minimize risk, damage, and production downtime.
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European region is expected to hold a substantial share of the global fire protection market during the forecast period.
The European market consists of countries, such as Germany, the UK, France, and the Rest of Europe. The European fire protection system industry is well developed due to government regulations to safeguard building occupants from fire accidents by installing fire safety systems. Governments have collectively or independently developed fire prevention and protection guidelines. Fire accidents have reiterated that the need to set up fire protection systems has increased, fueling market growth. European countries are home to wireless fire detection system manufacturers. Moreover, the evolution of wireless technologies has driven the fire protection system market in this region. Stringent government mandates for installing smoke detectors and alarms in households have also been introduced in the UK, France, and Germany.
The key players in the fire protection system companies include Carrier (US), Honeywell International Inc. (US), Johnson Controls (Ireland), Robert Bosch GmbH (Germany), Siemens (Germany), and others.
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HUMAN CAPABILITY INITIATIVE CONCLUDES IN RIYADH, MARKING THE BIGGEST-EVER GLOBAL CONFERENCE IN UNITING THE WORLD TO ADVANCE HUMAN CAPABILITY
RIYADH, Saudi Arabia, March 1, 2024 /PRNewswire/ — The Human Capability Initiative (HCI) concluded today in Riyadh, Saudi Arabia, bringing in a new era in global collaboration for human capability development. HCI was held under the patronage of His Royal Highness Prince Mohammed bin Salman bin Abdulaziz Al Saud, Crown Prince, Prime Minister, and Chairman of the Human Capability Development Program (HCDP) Committee.
This groundbreaking forum gathering over 10,000 registered participants from more than 100 countries has set a precedent for international efforts in harnessing human potential, culminating in over 50 strategic partnerships and launches. These collaborations, spanning diverse sectors from education to artificial intelligence, mark significant strides toward global human capability enhancement.
Notable announcements include the Saudi Ministry of Education’s educational visa program set to make Saudi Arabia a global learning hub for over 132,000 international students, researchers, and professors, aligning with the Kingdom’s Vision 2030 aspirations to attract and retain worldwide talent.
The Saudi Ministry of Education will also contribute to revolutionizing education in lower-income countries by officially joining the Global Partnership for Education (GPE) with a substantial $38 million contribution to equip young generations with the necessary skills for jobs of the future.
As the Kingdom prioritizes the future readiness of Saudi students across all disciplines, the Saudi Ministry of Education has unveiled plans to elevate its Curriculum Development Center into a national autonomous entity under the direct supervision of the Minister of Education. This revamped Center will focus on strategic curriculum planning and development aligned with international best practices and emerging global trends, preparing future generations for success in an ever-evolving world.
Further adding to the successes HCI has brought, groundbreaking education partnerships were struck between Saudi Arabia and some of the world’s biggest sector leaders including Porsche, Hyundai, LinkedIn, and IE University, leveraging the power of international collaboration to accelerate human capability development at home and abroad.
These initiatives, alongside others announced during the event, underscore HCI’s role as an enabling platform for impactful collaboration and a necessary catalyst for future-ready human capability development across the globe.
The conference featured a robust agenda, with over 100 insightful sessions led by global and local luminaries in government, industry, and academia including thoughtful future-facing discussions featuring Ministers of Education from around the world. Discussions spanned crucial topics such as the sustainability skill gap, job automation by AI, and the future of education and workforce adaptability, emphasizing the central role of human potential in addressing contemporary global challenges.
The CEO of HCDP, Engineer Anas AlMudaifer, commented: “HCI has inspired collaboration among the brightest minds in the world to future-proof people. Thought provoking ideas shared at HCI have and the thought-provoking ideas shared, and impact-driven partnerships forged today have reaffirmed that commitment. Unlocking the full potential of humanity requires global collaboration, and Saudi Arabia, as a global convenor, is sparking dynamic dialogue through HCI. The huge success of HCI has energized the world of human capability development, serving as an inspirational platform for more knowledge and collaborations to come, and more importantly, demonstrated that together, we can truly unlock the full potential of our societies.”
Saudi Arabia is undergoing a profound transformation under Vision 2030 that aims to create opportunities for citizens, open the Kingdom to the world and diversify its economy. At the heart of Vision 2030 lies the people, who embody the ambition of Saudi transformation. This belief in people is the aspiration behind the hosting of Human Capability Initiative, sparking actions among changemakers in governments, private sector and non-profit organizations globally to invest in the most valuable resource of our society – the people.
Contact: Tariq Al Qwaifel, +966 56 466 6669, [email protected]
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