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DelveInsight Highlights Major Advances, Transformative Therapies, and 15+ Leading Players Wheeling the Degenerative Disc Disease Pipeline Landscape
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New York, USA, Feb. 20, 2023 (GLOBE NEWSWIRE) — DelveInsight Highlights Major Advances, Transformative Therapies, and 15+ Leading Players Wheeling the Degenerative Disc Disease Pipeline Landscape
The prevalence of degenerative disc disease has been rising over the past few years, which prompts the growing demand for treatment options. The increasing prevalence of degenerative disc disease and the growing research and development activities to develop novel therapies to treat degenerative disc disease to drive the market. The companies developing the potential therapies in the last stage of development include Spine BioPharma, Inc, Mesoblast, Ltd., BioRestorative Therapies, and several others.
DelveInsight’s ‘Degenerative Disc Disease Pipeline Insight – 2023‘ report provides comprehensive global coverage of available, marketed, and pipeline degenerative disc disease therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the degenerative disc disease pipeline domain.
Key Takeaways from the Degenerative Disc Disease Pipeline Report
- DelveInsight’s degenerative disc disease pipeline report depicts a robust space with 15+ active players working to develop 15+ pipeline therapies for degenerative disc disease treatment.
- Key degenerative disc disease companies such as Spine BioPharma, Inc., Angitia Biopharmaceuticals, Mesoblast, Ltd., BioRestorative Therapies, DiscGenics, Inc., Biosplice Therapeutics, Notogen, AnGes, Inc., FibroGenesis, Genequine Biotherapeutics, Causeway Therapeutics, Boehringer Ingelheim, SpineOvations, BIOPHARM GmbH, Yuhan, Histogen Inc., and others are evaluating new drugs for degenerative disc disease to improve the treatment landscape.
- Promising degenerative disc disease pipeline therapies in various stages of development include SB-01, AGA111, Rexlemestrocel-L, BRTX-100, IDCT, Lorecivivint, AMG0103, CybroCell, GQ-401, CWT 002, DiscSeal, rhGDF-5, HST 004, and others.
- In January 2023, VySpine, that it has received 510(k) clearance from the FDA for its LumiVy NanoVy Ti Lumbar IBF System, which is indicated for intervertebral body fusion for use at either one level or two contiguous levels in the lumbar spine, from L2 to S1, for the treatment of degenerative disc disease (DDD) with up to Grade 1 spondylolisthesis.
- In January 2023, Notogen, Inc. announced that it had entered a worldwide research collaboration and license agreement with Boehringer Ingelheim to develop and commercialize a Notogen regenerative therapeutic that has the potential to become a first-in-class, disease modifying treatment for people living with degenerative disc disease (DDD).
- In November 2022, Spinal Stabilization Technologies (SST) announced the start of the LOPAIN2 clinical trial of the PerQdisc™ Nucleus Replacement Device (NRD). SST’s PerQdisc Nucleus Replacement Device will be studied in patients with degenerative disc disease (DDD) of the lumbar spine, which causes severe back pain, in patients without stenosis or instability. The PerQdisc is used for surgical replacement of a single nucleus pulposus between spinal lumbar discs L1-S1 using an anterior or lateral transpsoas approach. Currently, there is no good surgical option for these patients. SST’s PerQdisc NRD aims to treat discogenic low back pain while maintaining disc height and preserving range of motion.
- In February 2022, DiscGenics, Inc., announced the presentation of positive interim data from its ongoing Phase I/II clinical trial of IDCT (rebonuputemcel), an allogeneic injectable discogenic cell therapy for degenerative disc disease (DDD), at Spine Summit 2022. The primary efficacy endpoint of the study (n=60) was achieved, with statistically significant improvement in back pain observed in the high dose IDCT group. For these patients, low back pain scores improved >30% as measured on a 100mm Visual Analog Scale (VAS) at Weeks 12 (–54.53% [–69.46, –39.60], p=0.0056), 26 (–50.94% [–66.10, –35.78], p=0.0140), and 52 (–62.79% [–77.13, –48.46], p=0.0005).
- In January 2022, Mesoblast Limited announced 36-month follow-up results from the 404-patient Phase III trial of its allogeneic cell therapy rexlemestrocel-L (MPC-06-ID) in patients with chronic low back pain (CLBP) associated with degenerative disc disease (DDD).Results presented from this trial showed that: Durable reduction in pain through 36 months was greatest in the pre-specified population with CLBP of shorter duration than the study median of 68 months (n=194), suggesting that greatest benefits may be seen when the therapy is administered earlier in the disease process when there is active inflammation and before irreversible fibrosis of the intervertebral disc has occurred.
Request a sample and discover the recent advances in degenerative disc disease treatment drugs @ Degenerative Disc Disease Pipeline Report
The degenerative disc disease pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage degenerative disc disease drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the degenerative disc disease clinical trial landscape.
Degenerative Disc Disease Overview
The term “degenerative disc disease” (spondylosis) refers to the regular changes that occur in human spinal discs as they age. Normally, the discs act as shock absorbers for the human spine, allowing the body to flex, bend, and twist. This disease frequently causes various disorders, including lumbar spinal stenosis, spondylolisthesis, and retrospondylolisthesis. Approximately 90% of people will experience debilitating back pain at some point in their lives. The vast majority of cases are asymptomatic. The most common degenerative disk disease symptoms are neck pain and back pain.
The goal of degenerative disk disease treatment is to alleviate pain and prevent further damage. If other treatments fail, the doctor may suggest surgery. A discectomy is a procedure that removes the injured part of the disk. This relieves tension on the nerves. Sometimes, the doctor may remove the entire disk and replace it with an artificial one. If the patient has a severe problem, the doctor may fuse (permanently connect) the bones in the spine after the disk is removed.
Find out more about degenerative disc disease treatment drugs @ Drugs for Degenerative Disc Disease Treatment
A snapshot of the Degenerative Disc Disease Pipeline Drugs mentioned in the report:
Drugs | Company | Phase | MoA | RoA |
SB-01 | Spine BioPharma, Inc | Phase III | Nerve growth factor inhibitors; Transforming growth factor beta receptor antagonists | Intradiscal injection |
Rexlemestrocel-L | Mesoblast, Ltd. | Phase III | Cell replacements | Injection |
BRTX-100 | BioRestorative Therapies | Phase II | Cell replacements | Intradiscal Injection |
Lorecivivint | Biosplice Therapeutics | Phase I | Wnt signaling pathway inhibitors | Intradiscal injection |
CWT 002 | Causeway Therapeutics | Discovery | MicroRNA modulators | NA |
Learn more about the emerging degenerative disc disease pipeline therapies @ Degenerative Disc Disease Clinical Trials
Degenerative Disc Disease Therapeutics Assessment
The degenerative disc disease pipeline report proffers an integral view of degenerative disc disease emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration.
Scope of the Degenerative Disc Disease Pipeline Report
- Coverage: Global
- Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination
- Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
- Therapeutics Assessment By Route of Administration: Intra-articular, Intraocular, Intrathecal, Intravenous, Ophthalmic, Oral, Parenteral, Subcutaneous, Topical, Transdermal
- Therapeutics Assessment By Molecule Type: Oligonucleotide, Peptide, Small molecule
- Therapeutics Assessment By Mechanism of Action: IL17A protein inhibitors, MAP-kinase-activated kinase 2 inhibitors, IL17F protein inhibitors, Janus kinase 1 inhibitors, Immunomodulators, Granulocyte macrophage colony stimulating factor antagonists
- Key Degenerative Disc Disease Companies: Spine BioPharma, Inc., Angitia Biopharmaceuticals, Mesoblast, Ltd., BioRestorative Therapies, DiscGenics, Inc., Biosplice Therapeutics, Notogen, AnGes, Inc., FibroGenesis, Genequine Biotherapeutics, Causeway Therapeutics, Boehringer Ingelheim, SpineOvations, BIOPHARM GmbH, Yuhan, Histogen Inc., and others.
- Key Degenerative Disc Disease Pipeline Therapies: SB-01, AGA111, Rexlemestrocel-L, BRTX-100, IDCT, Lorecivivint, AMG0103, CybroCell, GQ-401, CWT 002, DiscSeal, rhGDF-5, HST 004, and others.
Dive deep into rich insights for new drugs for degenerative disc disease treatment; visit @ Degenerative Disc Disease Medications
Table of Contents
1. | Degenerative Disc Disease Pipeline Report Introduction |
2. | Degenerative Disc Disease Pipeline Report Executive Summary |
3. | Degenerative Disc Disease Pipeline: Overview |
4. | Analytical Perspective In-depth Commercial Assessment |
5. | Degenerative Disc Disease Clinical Trial Therapeutics |
6. | Degenerative Disc Disease Pipeline: Late Stage Products (Pre-registration) |
7. | Degenerative Disc Disease Pipeline: Late Stage Products (Phase III) |
7.1 | Rexlemestrocel-L: Mesoblast, Ltd. |
8. | Degenerative Disc Disease Pipeline: Mid Stage Products (Phase II) |
8.1. | BRTX-100: BioRestorative Therapies |
9. | Degenerative Disc Disease Pipeline: Early Stage Products (Phase I) |
10. | Degenerative Disc Disease Pipeline Therapeutics Assessment |
11. | Inactive Products in the Degenerative Disc Disease Pipeline |
12. | Company-University Collaborations (Licensing/Partnering) Analysis |
13. | Key Companies |
14. | Key Products in the Degenerative Disc Disease Pipeline |
15. | Unmet Needs |
16. | Market Drivers and Barriers |
17. | Future Perspectives and Conclusion |
18. | Analyst Views |
19. | Appendix |
For further information on the degenerative disc disease pipeline therapeutics, reach out @ Degenerative Disc Disease Treatment Drugs
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About DelveInsight
DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences.
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Invitation to the presentation of ASSA ABLOY’s Q3 report on 23 October starting at 09:00am (CEST)
STOCKHOLM, Oct. 1, 2024 /PRNewswire/ — ASSA ABLOY will release its Q3 report 2024 on Wednesday 23 October 2024 at 08:00 am (CEST). A conference call and webcast will be held following the release of the results, starting at 09:00 am (CEST) and continuing until 10:00 am (CEST). The presentation will be hosted by Nico Delvaux, President & CEO, and Erik Pieder, CFO, followed by questions and answers.
Slides used during the presentation will be available shortly after the release of the report on our website.
Enter the conference call and download presentation material at:assaabloy.com/investors
The details for participation by telephone are as follows:
Participants in Sweden should call +46 8 5051 00 31Participants in UK/Europe should call +44 207 107 06 13Participants in US should call +1 631 570 56 13Other international numbers available HEREFor more information, please contact:Isabelle Ewerlöf, Investor Relations Officer, tel: +46 8 506 485 74
This information was brought to you by Cision http://news.cision.com
https://news.cision.com/assa-abloy/r/invitation-to-the-presentation-of-assa-abloy-s-q3-report-on-23-october-starting-at-09-00am–cest-,c4044794
The following files are available for download:
https://mb.cision.com/Public/7333/4044794/87a98230b5054c2e.pdf
Q3 invitation
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Breaking barriers in Operational Technology: Meet Treon Connect
TAMPERE, Finland, Oct. 1, 2024 /PRNewswire/ — Treon, a leader in IoT technology launches Treon Connect, a platform designed to tackle challenges in operational technology (OT). Founded by innovators with a background in ‘connecting people,’ Treon has evolved to focus on connecting operations, leveraging its expertise in IoT and data acquisition.
Despite industrial digitalization progress, physical operations still face significant challenges. Treon Connect is built to overcome these obstacles, offering businesses the tools to enhance operational efficiency and sustainability.
“Siloed vertical solutions hinder scalability, increase costs and enforce manual workflows” said Joni Korppi, CEO of Treon. “At Treon, we developed Treon Connect to address these challenges, drawing on our experience in delivering IoT solutions for large-scale deployments with 150+ customers, including 50 global leaders.”
Treon Connect works alongside customers’ existing systems, enabling data-driven automation, and helping organizations improve operations by:
Enhancing efficiency: Reducing operational costs and extending asset lifespan through increased uptime and optimal use.Prioritizing worker safety: Reducing downtime and providing safer, more controlled environments.Seamless integration: Integrates with existing IT and OT systems.Minimizing environmental impact: Sustainable products that cut emissions, boost energy efficiency, and reduce waste.As part of Treon Connect, Treon launches:
Treon Apex applications for Condition Monitoring, Fleet Management, Network & Device Management, and Events for workflow automation.Treon Aito, the middleware that securely bridges applications, databases, and systems, is now available on cloud or on-premise, expanding support to third-party devices.Treon Industrial Node X, Treon’s latest wireless vibration sensor, offering market-leading capabilities, such as support for variable-speed machinery and a replaceable battery for sustainabilityTreon Gateway 2, a powerful edge computer, has been updated with cellular coverage for the USA, and telematics support for heavy equipment.Treon will launch Treon Connect at SMRP Annual Conference, October 7-10, 2024, in Orlando, FL, where they will showcase their latest innovations and continue introducing new use cases to enhance operations at a rapid pace together with ecosystem partners.
Visit treon.fi/treon-connect
About Treon
Treon is a leading technology company with a mission to help businesses improve productivity, enhance operational visibility, and sustainability. Its platform, Treon Connect, boosts operational efficiency by utilizing data-driven automation to extend machine lifespan, monitor assets, increase productivity, and ensure safety across industries. Treon is trusted by global leaders to provide secure, customized products that integrate seamlessly into existing business solutions.
Press inquiries
Samah Zain, Senior Growth [email protected]+358-505507331
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dsm-firmenich completes the sale of its MEG-3® fish oil business to KD Pharma Group SA
KAISERAUGST, Switzerland and MAASTRICHT, Netherlands, Oct. 1, 2024 /PRNewswire/ — dsm-firmenich, innovators in nutrition, health, and beauty, today announces the successful completion of the sale and transfer of its MEG-3® fish oil business for the Food & Beverage, Dietary Supplement and Pharma markets, together with the production facilities in Piura, Peru and Mulgrave, Canada.
As part of the transaction, dsm-firmenich received a minority stake of 29% in KD Pharma’s parent company MidCo Omega GmbH.
The sale and transfer of the business was announced on July 18, 2024. Financial details of the transaction will not be disclosed.
About dsm-firmenichAs innovators in nutrition, health, and beauty, dsm-firmenich reinvents, manufactures, and combines vital nutrients, flavors, and fragrances for the world’s growing population to thrive. With our comprehensive range of solutions, with natural and renewable ingredients and renowned science and technology capabilities, we work to create what is essential for life, desirable for consumers, and more sustainable for the planet. dsm-firmenich is a Swiss-Dutch company, listed on the Euronext Amsterdam, with operations in almost 60 countries and revenues of more than €12 billion. With a diverse, worldwide team of nearly 30,000 employees, we bring progress to life every day, everywhere, for billions of people. www.dsm-firmenich.com
For more information
Media relationsRobin Roothanstel. +41 (0)79 280 03 96e-mail [email protected]
Investor relationsDave Huizingtel. +31 (0)88 425 7306e-mail [email protected]
Forward-looking statementsThis press release may contain forward-looking statements with respect to dsm-firmenich’s future (financial) performance and position. Such statements are based on current expectations, estimates and projections of dsm-firmenich and information currently available to the company. dsm-firmenich cautions readers that such statements involve certain risks and uncertainties that are difficult to predict and therefore it should be understood that many factors can cause actual performance and position to differ materially from these statements. dsm-firmenich has no obligation to update the statements contained in this press release, unless required by law. The English language version of the press release is leading.
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