Artificial Intelligence

HTG Highlights the Advantages of Its Drug Discovery Engine

Published

1 year ago

May 16, 2023

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TUCSON, Ariz., May 16, 2023 (GLOBE NEWSWIRE) — HTG Molecular Diagnostics, Inc. (Nasdaq: HTGM) (HTG), a platform-based life science tools and drug discovery company, today reported achievement of another technical milestone in its drug discovery business.

HTG is pioneering a proprietary platform-based approach that is designed to help improve drug discovery, referred to as transcriptome-informed drug discovery and design. HTG’s objective is to develop best-in-class molecules for the treatment of diseases, with the ability to apply its platform agnostically across therapy areas. At the center of this approach is HTG’s proprietary RNA profiling technologies, functionally married with an advanced medicinal chemistry using a novel artificial intelligence (AI)-driven platform, allowing for the improved selection and design of molecules. Currently, the company’s most advanced discovery programs are in oncology with an emphasis on the treatment of acute myeloid leukemia (AML).

Using its proprietary platforms, HTG has successfully designed a first generation chemical library. The proportion of compounds with meaningful activity (hit rate) for this first library was approximately 25% in cell-based test system models. The company’s lead compounds target AML and have demonstrated in vitro efficacy both as standalone agents and in combination with current standards of care, with increased efficacy versus standard of care alone. Transcriptomic analysis of these cells revealed meaningful information that contributed to the understanding of the efficacy of the candidate molecules relative to the other compounds used as reference materials for this particular pharmacologic target. Most revealing and impressive about this outcome was that select HTG candidate molecules were found to be associated with key desirable biological differences in gene expression based on known biological pathways. These results included downregulating the expression of FLT3, a gene that is well-recognized to play a role in AML proliferation and that is also mutated in the majority of AML cases, and upregulating the expression of TET2, a known tumor suppressor gene where loss of signaling is linked to progression of this cancer. This reflects a desirable biological difference, especially when compared to the reference non-HTG comparator compound, where the expression of these particular genes was regulated in the opposite direction to the HTG compounds.

“Traditional drug discovery efforts are primarily limited to modality-target assays in vitro,” said Dr. Robert Spitale, Founding Associate Dean of Research and Professor, School of Pharmacy and Pharmaceutical Sciences at the University of California Irvine. “These assays, which have been valuable for the discovery of new drugs, do not represent the complexity of the cell. The hard part is understanding how drugs work on their targets and affect cell function and behavior – the ultimate goal would be to do drug discovery using assays that can tell developers what is happening to the entire cell system. To do so, we need robust and rapid assays, that also generate a lot of data to look at the entire cell response. This is the exciting part of HTG’s platform – a whole cell response that allows its users to dig into the details. What’s more, connecting changes in RNA expression to expected or desired outcomes of a drug screen function is a big leap forward and strongly supports the premise of HTG’s new direction in drug discovery.”

The findings and other data generated from the first library have been fed back into HTG’s AI-driven discovery engine and a second generation of candidate molecules has been rendered, with a hit rate for this subsequent library of approximately 35%. Subsequent in vitro efficacy studies on this second generation of molecules have also demonstrated further improvement in efficacy in cell-based test system models.

The lead molecules for this second library are currently progressing through the remaining portion of lead optimization and HTG expects to have sufficient data to support entry of these lead candidate molecules into development in the third quarter of 2023. The company has estimated market opportunity for the initial oncology indication for its first drug candidate at approximately $600M globally. Additionally, the company believes that the target potentially has additional value in at least six or more solid tumor indications based upon initial efficacy data generated by HTG in these other cancers.

“I see the data that our team has generated in these studies as a tangible demonstration of the power of the drug discovery engine we have built,” said Dr. Stephen A. Barat, SVP of Therapeutics at HTG. “We have demonstrated that we can progress from target to drug candidate in approximately 12 months with this platform approach, with the added benefit of having much deeper knowledge about the biological responses in diseased cells at these earlier development stages. We believe this ability to enrich our understanding of the mechanism of action for the lead compounds will allow us to make more informed selection choices far earlier in the process, which in turn will translate into greater chances for success in development.

“We continue to advance the capabilities of our discovery platform, including an exciting capability which is allowing us to use transcriptomic signatures representative of cellular perturbation from pharmacologic target modulation as a starting point where the AI system can design molecules, thus creating a capability for two way ‘conversations’ between chemistry and biology,” Dr. Barat continued. “This further increases the utility of this discovery platform for not only selecting and designing new molecules, but also as a key tool in potentially repurposing other drugs.”

About HTG:

HTG is accelerating precision medicine from diagnosis to treatment by harnessing the power of transcriptome-wide profiling to drive translational research, novel therapeutics and clinical diagnostics across a variety of disease areas.

Building on more than a decade of pioneering innovation and partnerships with biopharma leaders and major academic institutes, HTG’s proprietary RNA platform technologies are designed to make the development of life science tools and diagnostics more effective and efficient and to unlock a differentiated and disruptive approach to transformative drug discovery. For more information visit www.htgmolecular.com.

Forward-Looking Statements:

Statements contained in this press release regarding matters that are not historical facts are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, including statements regarding HTG’s objectives and ability to develop best-in-class molecules; the ability of HTG’s platform to enable improved selection and design of molecules; HTG’s expectations to have sufficient data to support entry of its lead candidate molecules into development in the third quarter of 2023; the estimated market opportunity for the initial oncology indication for HTG’s first drug candidate and the potential for other solid tumor indications for the same target; the potential of HTG’s AI-driven drug discovery engine; HTG’s ability to progress from target to drug candidate using its platform approach in approximately 12 months; the ability of HTG’s platform to potentially repurpose other drugs; HTG’s expected pipeline advancement; and the capabilities of HTG’s technology. Words such as “designed to,” “believe,” “anticipate,” “expect,” “potential,” “will” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements necessarily contain these identifying words. These forward-looking statements are based upon management’s current expectations, are subject to known and unknown risks, and involve assumptions that may never materialize or may prove to be incorrect. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, including risks associated with drug discovery and development; the risk that our technologies may not provide the benefits that we expect; risks associated with our ability to develop and commercialize our products; observations in cell-based test system models and in vitro efficacy results may not be replicated in trials in humans; risks associated with our ability to enter into licensing, partnering or other transactions for any candidates we discover or develop; the risk that our products and services may not be adopted by biopharmaceutical companies or other customers as anticipated, or at all; and risks related to our need for additional capital. These and other factors are described in greater detail in our filings with the Securities and Exchange Commission (SEC), including under the “Risk Factors” heading of our Quarterly Report on Form 10-Q for the quarter ended March 31, 2023, as filed with the Securities and Exchange Commission on May 10, 2023. All forward-looking statements contained in this press release speak only as of the date on which they were made, and we undertake no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.

HTG Investor Contact:

Ashley Robinson
LifeSci Advisors
Phone: (617) 430-7577
Email: [email protected]

Related Topics:AI Artificial Intelligence Machine learning

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Artificial Intelligence

Paperpal achieves major milestone; emerges as go-to AI writing assistant for 1 million academics globally

Published

1 hour ago

May 22, 2024

CISION (PR Newswire)

PRINCETON, N.J., May 22, 2024 /PRNewswire/ — Paperpal, the AI academic writing assistant by Cactus Communications (CACTUS), is proud to announce a significant milestone of surpassing one million users worldwide in just 18 months since its launch. This achievement underscores the trust academics have placed in Paperpal, which has evolved from being an editing tool to a comprehensive AI academic writing assistant, guiding users from ideation to submission readiness.

Leveraging over 22 years of scientific, technical, and medical (STM) experience, Paperpal is continually expanding and deepening its support for students, educators, and researchers globally, empowering them to streamline the academic writing process and deliver high-quality, original content faster than ever before.
Several factors have contributed to Paperpal’s rapid growth, including academic-focused features such as precise, contextual writing and editing suggestions, comprehensive checks, and a user-friendly interface. Moreover, early adoption by the global researcher community, particularly non-native English speakers, has played a pivotal role in driving its popularity. Paperpal’s commitment to prioritizing user feedback for continuous improvement is evident in its consistent high Net Promoter Score (NPS) of 70. This indicates the high user satisfaction and strong recommendations by leading universities, publishers, and academics from 125+ countries, including the United States, United Kingdom, Germany, Italy, Japan, and India.
Expressing excitement on this milestone, Abhishek Goel, Co-Founder & CEO, Cactus Communications, says, “We are thrilled to announce that Paperpal has reached this milestone. Our mission is to help researchers reach their highest potential, and Paperpal as a tool empowers them with assistance in ideation, writing, editing and overall submission readiness of their manuscripts. We look forward to continue to empower students and researchers worldwide to be able to do more with their time.”
Nishchay Shah, Chief Technology Officer and Head, Emerging Products, Cactus Communications, adds, “This milestone is a testament to the dedication of the entire team behind Paperpal, which is continually working to support academics in their research pursuits by building and harnessing the latest AI technologies. With our user feedback-driven roadmap philosophy and continuous iteration, we aim to be the #1 writing tool of choice for academics worldwide.”
Paperpal leverages secure generative AI to provide science-based insights, text suggestions, language and grammar correction, paraphrasing, translation, with plagiarism and submission readiness checks to help academics write better, faster, and move closer to publication success.
For more information, visit https://paperpal.com/
For more details, contact:Nidhi AminCactus Communications (CACTUS)Email: [email protected] | [email protected] Tel no.: +1-267-332-0051

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View original content:https://www.prnewswire.co.uk/news-releases/paperpal-achieves-major-milestone-emerges-as-go-to-ai-writing-assistant-for-1-million-academics-globally-302152617.html

Artificial Intelligence

NTT DATA to celebrate its success with SAP at the Sapphire and ASUG Annual Conference 2024

Published

1 hour ago

May 22, 2024

CISION (PR Newswire)

NTT DATA invites attendees at SAP Sapphire 2024 in Orlando and Barcelona to learn how to bring out the best in their business with SAP, across a range of hosted talks and sessions during the eventsNTT DATA will reveal “Transformation Study 2024” insights at the event in partnership with its subsidiary NatuvionAward Ceremony in Orlando: Four prestigious SAP© Pinnacle Awards underscore NTT DATA’s success as a key partner for SAP globallyBARCELONA, Spain and ORLANDO, Fla., May 22, 2024 /PRNewswire/ — NTT DATA, a global digital business and IT service provider, has announced today that it will celebrate its long and successful partnership with SAP by attending the upcoming SAP Sapphire 2024 conferences worldwide. NTT DATA will be a Platinum Sponsor at the SAP Sapphire and ASUG Annual Conference 2024 from 3-5 June 2024, in Orlando, Florida, and will also be a Platinum Sponsor at the SAP Sapphire event in Barcelona (11-13 June).

“SAP Sapphire is always a highlight for us. We are the top winner this year with four Pinnacle Awards and five finalist recognitions. This underscores the trust that SAP and our customers have in our 35 years of expertise,” said Norbert Rotter, CEO of NTT DATA Business Solutions and EVP NTT DATA, Inc.
Transformation Study to be released at SAP Sapphire
In collaboration with its subsidiary Natuvion, NTT DATA will unveil the Transformation Study 2024 at the SAP Sapphire conference in Orlando and will make it available for download at their booth during both Orlando and Barcelona events. The report will provide in-depth insights into the challenges, success factors and lessons learned by enterprises during the transition from legacy IT systems to modern, innovative technologies. With perspectives from industry leaders in Germany, Austria, Switzerland, Norway, Finland, Sweden, Denmark, UK and the USA, the study reveals how their organizations are modernizing their IT infrastructure and planning for their future.
Celebrate with NTT DATA in Orlando and Barcelona
Meet us in Orlando to learn how we can help power intelligent and sustainable enterprises and ignite tomorrow, today with innovative technology solutions, industry domain expertise and an assortment of SAP lifecycle-based tools and accelerators. Leaders from four NTT DATA Group organisations will address the following topics in Sapphire theatre presentations:
4th June, 10:30am, Orlando – Transforming SugarCreek for Tomorrow with SAP S/4HANA (Strategy Talk)4th June, 11:00am, Orlando – NTT DATA and SAP Preferred Success: Maximizing Value for SugarCreek (Customer Success Story)12th June, 1:30pm, Barcelona – Andel: Transitioning two SAP ECC systems to SAP S/4HANA in the cloudMake sure to stop by our booth or schedule a meeting with our SAP experts who will be available in booth #351 in Orlando, Florida and booth #5.305 in Barcelona, Spain.
For more information visit nttdata-solutions.com.
About NTT DATA
NTT DATA is a $30+ billion trusted global innovator of business and technology services. We serve 75% of the Fortune Global 100 and are committed to helping clients innovate, optimize and transform for long-term success. We invest over $3.6 billion each year in R&D to help organizations and society move confidently and sustainably into the digital future. As a Global Top Employer, we have diverse experts in more than 50 countries and a robust partner ecosystem of established and start-up companies. Our services include business and technology consulting, data and artificial intelligence, industry solutions, as well as the development, implementation and management of applications, infrastructure, and connectivity. We are also one of the leading providers of digital and AI infrastructure in the world. NTT DATA is part of NTT Group and headquartered in Tokyo. Visit us at nttdata.com
SAP and other SAP products and services mentioned herein as well as their respective logos are trademarks or registered trademarks of SAP SE in Germany and other countries. Please see https://www.sap.com/copyright for additional trademark information and notices. All other product and service names mentioned are the trademarks of their respective companies.

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Artificial Intelligence

BeCause and d2o Team Up to Create First-of-its-Kind CSRD Solution for the Travel and Hospitality Industries

Published

1 hour ago

May 22, 2024

CISION (PR Newswire)

Combining d2o’s PMI GoGreen environmental management tool and BeCause’s sustainability data management platform offers hotels the only CSRD compliance solution rooted in efficiency and profitability.
NICE, France, May 22, 2024 /PRNewswire/ — BeCause, the Danish start-up transforming how the global hospitality, travel, and tourism industries manage their sustainability data, has partnered with d2o, a leading forecasting and resourcement management technology provider for the hospitality industry, to create a comprehensive Corporate Social Responsibility Directive (CSRD) solution for hotels. The collaboration unites the BeCause Sustainability Hub with d2o’s PMI GoGreen suite of prediction, targeting, tracking, and allocation tools to create an auditable CSRD reporting solution that goes beyond compliance to boost efficiency and profits. The partnership was announced yesterday at the World Sustainable Hospitality Alliance Spring Summit in Nice, France.

By joining forces, BeCause and d2o have taken a giant leap toward building a viable, valuable ecosystem between the hotel industry and technology providers that leverages the power and potential of daily sustainability data management. CSRD compliance is just the starting point; BeCause and d2o are demonstrating that with the right technology, sustainability initiatives can drive operational efficiency and profitability for hotels around the world.
“As an inventor and entrepreneur, it is a dream come true to have a product that fully meets the needs of our customers’ stakeholders, including owners, guests, staff, authorities, and local communities,” says d2o CEO Young Nguyen. “The partnership between d2o and BeCause will enhance the hotel industry’s ability to transform a costly compliance challenge into a business opportunity. We call this partnership PMI GoGreen BeCause… because the hotel industry and the planet require a comprehensive solution to address a complex issue.”
Going Beyond CSRD Reporting and Compliance
As a result of this partnership, the PMI GoGreen tools will be seamlessly integrated into the BeCause platform. This integration, facilitated by an API, allows for the sharing and mapping of data, making it reusable for CSRD reporting. This not only simplifies the compliance process for hotels but also ensures accuracy and auditability at the activity level, meeting financial-grade CSRD reporting standards.
However, the joint solution goes beyond compliance and reporting. By centralizing data within the BeCause platform and applying the integrated PMI GoGreen tools, hotel chains gain visibility into which individual properties are meeting their targets for reducing CO2 emissions, energy consumption, water usage chemicals, waste, towels & linens, and food waste. The combined solution also utilizes machine learning algorithms and predictive analytics to identify those targets and help properties optimize resource usage to meet them amidst daily fluctuating demand. System integration service ensures seamless interoperability between the BeCause Sustainability Hub, PMI GoGreen tools, and various internal hotel systems, including property management, point-of-sale, table reservations, sales and catering, timekeeping, and more.
These combined capabilities allow hotels to increase efficiency—hotels are projected to reap 12-15% in resource savings—cultivate ownership among frontline managers, showcase their sustainability efforts to travelers, and, of course, meet their CSRD compliance obligations.
“We believe in the power of ecosystems, and by partnering with d2o, we’ve built a particularly effective one,” says BeCause CEO and Co-founder Frederik Steensgaard. “Not just in terms of helping hotels reach CSRD compliance, but by using the combined capabilities of our solutions to address everyday issues that impact their margins and organizational effectiveness. Why should compliance and reporting be a cost-heavy headache for hotels when it could be driving profitability and operational efficiency?”
An Efficient Solution Specifically Designed for Hospitality
BeCause is a purpose-built, AI-powered hub that centralizes a hotel’s sustainability data and automates the transmission of that data amongst different stakeholders, such as travel and accommodation booking marketplaces and industry certifications. Additionally, once a hotel enters its data into the BeCause platform, it can be upcycled and automatically mapped to multiple frameworks, making qualifying for voluntary green certifications faster and more efficient while ensuring regulatory compliance.
The PMI GoGreen suite of tools developed by d2o enables hospitality groups to achieve their long-term environmental goals by breaking them down into monthly targets tailored to each property’s attributes and seasonal variations. Each hotel’s future targets are dynamically adjusted based on progress, ensuring the consistency of the group’s end goal. Individual hotels and hotel chains can track their progress with forward looking data-based indicators and utilize predictive analytics to optimize resource allocation, minimize waste, and cut operating costs.
The combined PMI GoGreen BeCause solution leverages these capabilities to deliver at least 100% ROI for hotels that implement it. The solution will undergo a phased roll-out through the summer of 2024 before formally launching in September.
For more information about BeCause, d2o or the partnership, or to request an interview, please contact: Vanessa Horwell at [email protected] for BeCause CEO and Co-founder, Frederik Steensgaard or Young Nguyen [email protected] for d2o, Founder and CEO.
About BeCauseBeCause is an enterprise software company that streamlines the flow of sustainability data and creates synergies between different stakeholders in the travel, tourism, and hospitality industries, empowering them to make decisions that result in positive, responsible change for people, the planet, and their profits. BeCause works with over 25,000 hotels, including brands like Radisson, certification entities like GreenKey, industry partners like the Global Sustainable Tourism Council and the SHA, and marketplaces like Booking.com. For more information, visit because.eco.
About d2o and PMI GoGreenFounded in Norway and built on Scandinavia’s legacy of employee well-being and sustainability, d2o has over 20 years of experience helping clients optimize resources for maximum profit while navigating high-cost environments. The company’s PMI GoGreen Environmental Management System (EMS) empowers hotel managers to surpass compliance and achieve true sustainability. Leveraging auditable data, predictive analytics, and hotel demand, PMI GoGreen reduces CO2 emissions and the usage of critical resources like energy, water, and food and transforms hotel sustainability obligations into a profitable, cross-functional endeavor. For more information, please visit www.d2o.com/sustainability-gogreen-with-pmi-by-d2o/.

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