Artificial Intelligence
Kanazawa University research: Researchers define a nanopipette fabrication protocol for high resolution cell imaging
KANAZAWA, Japan, Aug. 22, 2023 /PRNewswire/ — Researchers at Kanazawa University report in Analytical Chemistry how to produce nanopipettes that reliably provide nanoscale resolution scanning ion conductance microscopy images of living cells.
A nanoscale view of living cells can provide valuable insights into cell structure and function. Over the years, various microscopy techniques have been enrolled to obtain a window into biological specimens at the nanoscale but all with their limitations and challenges. Although scanning ion conductance microscopy (SICM) has demonstrated the capability to image living biological samples in solution with nanoscale resolution, it has been hampered by challenges in reliably producing nanopipettes with the optimum geometry for the job. Now researchers led by Yasufumi Takahashi at Kanazawa University’s Nano LSI and Nagoya University have devised a protocol for reproducibly fabricating nanopipettes with the preferred geometry for high quality imaging. Scanning ion conductance microscopy (SICM) uses a nanopipette to control the nanopipette-samples distance using an ion current as feedback signal. The shape of the nanopipette significantly influences the performance of the device. For instance, a wide aperture limits the possible resolution, a long shunt can lead to rectification effects that warp the ion current measurements, and if the glass of the nanopipette is too thick it can deform the sample before the proximity of the aperture has reached the point needed for constant ion current topographical mapping. As a result, the ideal nanopipette has a short shunt, small aperture and thin glass walls.
The standard procedure for fabricating the nanopipette is to pull a capillary tube with a laser puller that heats the capillary tube it is manipulating. The capillary then narrows where it lengthens until it is finally drawn into two separate pieces. Although quartz can allow a little more control in the process of drawing the capillary tube into shape it is hydrophobic, which raises complications in actually filling the nanopipette with the aqueous solution needed for the ion current. In this reason, the researchers developed a protocol by which they could draw nanopipettes from borosilicate glass capillaries with the required control and reproducibility.
Takahashi and his collaborators noted that ideally the starting capillary should have thick walls and a narrow inner diameter, however it is not easy to obtain capillary tubes to these requirements from commercial suppliers. Instead, they preheat the capillary for 5 s without pulling it, which causes the glass walls to the thicken and reduces the inner diameter. They also optimized the parameters for pulling the tube, such as the velocity.
The researchers demonstrated the performance of the nanopipettes they produced by imaging a cell undergoing a type of endocytosis, where it engulfs and absorbs some external material. They were able to image the microvilli – cellular membrane protrusion – on the cell surface, the endocytic pits that form and the formation of a cap closing up the pit. Previously attempts to image the cap formation have been inhibited by limitations in the spatial resolution.
The researchers were even able to resolve extracellular vesicles as small as 189 nm released in the process. As they point out in their report there is increasing evidence that these extracellular vesicles play an important role in communication between cells and homeostasis, with diagnostic and therapeutic applications focused on the smaller extracellular vesicles between 40 nm and 150 nm in particular. The researchers conclude in their report, “We envision this protocol will help to reproducibly fabricate borosilicate nanopipettes for high-resolution topographical mapping using SICM.”
Image link https://nanolsi.kanazawa-u.ac.jp/wp/wp-content/uploads/fig1-6.jpg© 2023 American Chemical Society
Caption: Fig 1. New method for fabricating nanopipette and ultra-high-resolution imaging of its shape. Upper left: Glass capillary after preheating to deform glass. Â Lower left: Electron micrograph of a nanopipette tip; Right: SICM image of the surface of a fixed HeLa cell.
Glossary
Scanning ion conductance microscopy
The basic principle behind scanning ion conductance microscopy (SICM) relies on monitoring the ion current that flows through a nanopipette containing some kind of electrolyte. It can map the topography of a sample by adjusting the nanopipette height to maintain a constant ion current as it is scanned over the sample surface. The proximity to the sample surface has a measurable effect on the ion flow and hence current before the tip makes contact with the sample, making it useful for biological specimens that might be easily damaged. It also works well in solution whereas techniques such as electron microscopy require the sample to be fixed.
SICM has been used in hopping mode – where the pipette approaches and retracts from the sample, further lowering the potential for sample damage, particularly where the sample surface is not flat. However, it takes longer due to the vertical distances travelled by the nanopipette and can suffer from more noise. In this report the authors showed that their high performance nanopipettes eliminated the need for hopping mode measurements for their samples.
Extracellular vesicle
These are particles bound by a lipid bilayer that all cells produce, although unlike a cell they do not themselves reproduce. There has been a recent surge of interest in them as studies reveal their likely role in transferring signals, which has led to them being described as a “novel -crine system” in analogy to the endocrine system that secretes hormones to send signals around the body.
ReferenceYasufumi Takahashi, Yuya Sasaki, Takeshi Yoshida, Honda Kota, Yuanshu Zhou, Takafumi Miyamoto, Tomoko Motoo, Hiroki Higashi, Andrew Shevchuk, Yuri Korchev, Hiroki Ida, Rikinari Hanayama, Takeshi Fukuma. Nanopipette Fabrication Guidelines for SICM Nanoscale Imaging, Analytical Chemistry August 20, 2023.DOI：10.1021/acs.analchem.3c01010URL: https://doi.org/10.1021/acs.analchem.3c01010
ContactHiroe YonedaSenior Specialist in Project Planning and OutreachNanoLSI Administrative OfficeWPI Nano Life Science Institute (WPI-NanoLSI)Kanazawa UniversityKakuma-machi, Kanazawa 920-1192, JapanEmail: [email protected]: +81 (76) 234-4550
About Nano Life Science Institute (WPI-NanoLSI)
Nano Life Science Institute (NanoLSI), Kanazawa University is a research center established in 2017 as part of the World Premier International Research Center Initiative of the Ministry of Education, Culture, Sports, Science and Technology. The objective of this initiative is to form world-tier research centers. NanoLSI combines the foremost knowledge of bio-scanning probe microscopy to establish ‘nano-endoscopic techniques’ to directly image, analyze, and manipulate biomolecules for insights into mechanisms governing life phenomena such as diseases.
https://nanolsi.kanazawa-u.ac.jp/en/
About Kanazawa University
As the leading comprehensive university on the Sea of Japan coast, Kanazawa University has contributed greatly to higher education and academic research in Japan since it was founded in 1949. The University has three colleges and 17 schools offering courses in subjects that include medicine, computer engineering, and humanities.
The University is located on the coast of the Sea of Japan in Kanazawa – a city rich in history and culture. The city of Kanazawa has a highly respected intellectual profile since the time of the fiefdom (1598-1867). Kanazawa University is divided into two main campuses: Kakuma and Takaramachi for its approximately 10,200 students including 600 from overseas.
http://www.kanazawa-u.ac.jp/e/
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Artificial Intelligence
Healthcare Analytics Market to Garner a Valuation of USD 139.34 Billion by 2030, Exhibiting 23.31% CAGR, With North America Leading the Market Due to Advanced Healthcare Infrastructure, Projects Kings Research
DUBAI, UAE, Oct. 3, 2023 /PRNewswire/ — As per the latest report published by Kings Research, the global Healthcare Analytics Market size was recorded at USD 24.45 billion in 2022 and is estimated to grow to USD 139.34 billion by 2030, exhibiting a CAGR of 23.31% over the forecast period of 2023- 2030. The healthcare industry has embraced analytics to address the challenges of inadequate patient care, rising treatment costs, and low levels of patient engagement and retention. By leveraging healthcare analytics, the industry aims to improve patient care and operational efficiency, which is fueling market expansion.
Healthcare analytics leverages extensive data collection to provide organizations with practical insights, enabling them to make informed decisions in real-time. Through analytical methodologies, these insights facilitate improved planning, management, measurement, and learning. Furthermore, healthcare institutions around the globe are prioritizing cost reduction, enhancing care team coordination, and elevating patient care. Moreover, newer market entrants are introducing innovative healthcare delivery approaches, intensifying market competition. Consequently, healthcare analytics systems primarily concentrate on big data, offering potential benefits such as cost reduction, enhanced efficiency, and better patient treatment.
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Competitive Landscape
Key participants in the global healthcare analytics market are emphasizing acquisitions as a primary approach for expanding their businesses. For instance, in June 2022, Oracle Corporation took over Cerner Corporation intending to integrate Cerner’s clinical abilities with its own expertise in enterprise platform analytics and automation.
Leading companies in the global healthcare analytics market include:
Optum, Inc.Wipro LimitedAllscripts Healthcare, LLCCerner CorporationHealth CatalystInovalonMcKesson CorporationIBMMEDEANALYTICS, INC.GENERAL ELECTRICHave an Inquiry? Get in Touch with us @ https://www.kingsresearch.com/enquiry/healthcare-analytics-market-185
Trending Now: Mayo Clinic and Google Cloud Collaborate on AI for Healthcare Data
Google Cloud and Mayo Clinic have joined forces to implement generative artificial intelligence (AI) in the field of healthcare. This collaboration aims to empower clinicians and researchers to swiftly and naturally access information, as stated in a press release dated 7th June 2023.
In the same release, Google Cloud announced that the tool to be utilized in this endeavor, the Enterprise Search in Generative AI App Builder, had become HIPAA compliant. Thomas Kurian, CEO of Google Cloud, stated, “Generative AI has the potential to revolutionize healthcare by enhancing human interactions and streamlining operations like never before. Mayo Clinic is a global leader in harnessing AI for the greater good, and they are a crucial partner in responsibly introducing this transformative technology to healthcare.”
The press release also noted that Mayo Clinic has previously collaborated with Google Cloud to implement analytics, AI, and machine learning (ML) solutions in healthcare.
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Growing Demand for Descriptive Analysis to Spur Market Development
In terms of type, the healthcare analytics market is categorized into predictive analytics, prescriptive analytics, and descriptive analytics.
The descriptive analysis segment is anticipated to dominate the market through the projected timeframe. This growth is primarily attributable to the surging demand for descriptive analysis, which relies on historical patterns to obtain data-driven insights that can enhance the healthcare system’s management, benefiting both organizations and patients.
On Premise Solutions Garner Attention for Their Superior Accessibility in Remote Zones
On the basis of the delivery model, the global healthcare analytics industry is divided into on cloud and on premise.
The on premise segment is leading the market, propelled by its superior accessibility in remote areas. Furthermore, their lower maintenance and operation costs are driving the growth of the segment.
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Rising EHR Adoption to Drive Healthcare Analytics Market Expansion
The widespread use of electronic health records (EHR) has led to a substantial increase in the availability of data for analysis in the healthcare industry. As more healthcare professionals transition from traditional paper-based systems to EHR, a huge volume of data becomes accessible. This presents a unique opportunity to obtain valuable insights and enhance patient care. Consequently, the healthcare analytics market has experienced considerable growth in recent times.
The implementation of EHR has brought about greater operational efficiency and cost savings in healthcare organizations. With the ability to access and analyze real-time data, healthcare providers can identify trends, patterns, and areas for improvement in their workflows and procedures. This not only enhances their productivity but also helps them make informed decisions for better patient care. Moreover, integrating healthcare analytics into clinical decision support systems empowers practitioners to make evidence-based decisions, ultimately leading to enhanced patient outcomes. This widespread adoption of EHR and analytics has revolutionized the healthcare industry, ushering in a more data-driven and patient-centric approach to care.
North America to Lead Market Due to Advanced Healthcare Infrastructure
North America is poised to lead the global healthcare analytics market in the upcoming years due to its advanced healthcare infrastructure, robust technology, and data integration capabilities. This facilitates informed decision-making, enhances patient outcomes, and fosters healthcare innovation. Moreover, the region’s emphasis on R&D activities attracts industry leaders, solidifying its market dominance.
For more information on the report, visit: https://www.kingsresearch.com/healthcare-analytics-market-185
Key Points from TOC:
Chapter 1 Introduction of the Global Healthcare Analytics Market
1.1 Market Definition
1.2 Market Segmentation
1.3 Research Timelines
1.4 Limitations
1.5 Assumptions
Chapter 2 Executive Summary
Chapter 3 Research Methodology
3.1 Data Collection
3.1.1 Secondary Sources
3.1.2 Primary Sources
3.1.3 Research Flow
3.2 Subject Matter Expert Advice
3.3 Quality Check
3.4 Final Review
3.5 Bottom-Up Approach
3.6 Top-down Approach
Chapter 4 Global Healthcare Analytics Market Outlook
4.1 Market Evolution
4.2 Overview
4.3 Market Dynamics
4.3.1 Drivers
4.3.2 Restraints
4.3.3 Opportunities
4.3.4 Challenges
4.4 Pricing Analysis
4.5 Porter’s Five Forces Analysis
4.6 Value Chain Analysis
4.7 Macroeconomic Analysis
Chapter 5 Impact of Russia-Ukraine War
Chapter 6 Global Healthcare Analytics Market, By Type
Chapter 7 Global Healthcare Analytics Market, By Component
Chapter 8 Global Healthcare Analytics Market, By Delivery Model
Chapter 9 Global Healthcare Analytics Market, By Application
Chapter 10 Global Healthcare Analytics Market, By End User
Chapter 11 Global Healthcare Analytics Market, By Geography
Chapter 12 North America
Chapter 13 Europe
Chapter 14 Asia Pacific
Chapter 15 Middle East & Africa
Chapter 16 Latin America
Chapter 17 Global Healthcare Analytics Market Competitive Landscape
17.1 Overview
17.2 Key Developments
17.3 Key Strategic Developments
17.4 Company Market Ranking
17.5 Regional Footprint
17.6 Industry Footprint
Chapter 18 Company Profiles
18.1 Optum, Inc.
18.1.1 Key Facts
18.1.2 Financial Overview
18.1.3 Product Benchmarking
18.1.4 Recent Developments
18.1.5 Winning Imperatives
18.1.6 Current Focus & Strategies
18.1.7 Threat from competition
18.1.8 SWOT Analysis
18.2 Wipro Limited
18.2.1 Key Facts
18.2.2 Financial Overview
18.2.3 Product Benchmarking
18.2.4 Recent Developments
18.2.5 Winning Imperatives
18.2.6 Current Focus & Strategies
18.2.7 Threat from competition
18.2.8 SWOT Analysis
18.3 Allscripts Healthcare, LLC
18.3.1 Key Facts
18.3.2 Financial Overview
18.3.3 Product Benchmarking
18.3.4 Recent Developments
18.3.5 Winning Imperatives
18.3.6 Current Focus & Strategies
18.3.7 Threat from competition
18.3.8 SWOT Analysis
18.4 Cerner Corporation
18.4.1 Key Facts
18.4.2 Financial Overview
18.4.3 Product Benchmarking
18.4.4 Recent Developments
18.4.5 Winning Imperatives
18.4.6 Current Focus & Strategies
18.4.7 Threat from competition
18.4.8 SWOT Analysis
18.5 Health Catalyst
18.5.1 Key Facts
18.5.2 Financial Overview
18.5.3 Product Benchmarking
18.5.4 Recent Developments
18.5.5 Winning Imperatives
18.5.6 Current Focus & Strategies
18.5.7 Threat from competition
18.5.8 SWOT Analysis
Browse Complete TOC: https://www.kingsresearch.com/toc/healthcare-analytics-market-185
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Artificial Intelligence
Hard Rock and Leo Messi Unveil First Ever Menu for Kids: The Hard Rock Messi Kids Menu
HOLLYWOOD, Fla., Oct. 3, 2023 /PRNewswire/ — Hard Rock International and global brand ambassador, Leo Messi, are taking their partnership to the next level by curating their first-ever Messi menu for kids, “The Hard Rock Messi Kids Menu”. The menu launches today at all participating Hard Rock Cafes and select Hard Rock Hotels worldwide. Expanding on Hard Rock International’s partnership with the world-renowned soccer sensation, “The Hard Rock Messi Kids Menu” features the Messi X Burger, the Messi Golden Chicken Sandwich and other kid-friendly options, along with a special nod to the international sports icon in the form of a complimentary mini golden soccer ball toy, a collectable poster, activity sheet and stickers with every meal.
“As a father of three, I have always had a special connection with kids,” said Leo Messi. “Now with my partners at Hard Rock, we will kick-off the new kids menu, offering families a variety of tasty meals and a fun dining experience.”
Fans can also take some of the Messi magic home with them via a new collection of Hard Rock X Messi 3.0 merchandise, for both kids and adults, including a kid-sized version of the iconic Messi Chef’s Coat and a special mini soccer ball, available at select Rock Shops. A portion of proceeds from the mini soccer balls sold at the Rock Shop will be donated to kid’s charities around the world via the Hard Rock Heals Foundation.
“We’re very excited to partner with Leo Messi on this special addition to the Hard Rock menu,” said Jim Allen, Chairman of Hard Rock International. “We know how much children and their parents alike look up to Leo and we’re proud to offer something wholesome for the whole family to enjoy while visiting our locations around the world.”
For even more fun, fans can scan a QR code to enter a 360 digital experience with Leo Messi himself. They can watch an AI-generated Messi with the Messi Chicken Sandwich or greet fans at the Hard Rock Cafe. Also available on the 360 digital experience is access to purchase the new retail options for kids and adults, a trivia game, wallpaper downloads and more.
For assets from “The Hard Rock Messi Kids Menu” launch event, please see images and b-roll here. For the full release, visit https://news.hardrock.com/.
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Artificial Intelligence
Cloud ERP Market size worth USD 168.34 Billion, Globally, by 2030 at 12.53% CAGR: Verified Market Research®
The “Global Cloud ERP Market Size By Component, By Organization Size, By End-User, By Geographic Scope And Forecast” report has been published by Verified Market Research®. The report provides an in-depth analysis of the global Cloud ERP Market, including its growth prospects, market trends, and market challenges.
JERSEY CITY, N.J., Oct. 3, 2023 /PRNewswire/ — The Global Cloud ERP Market is projected to grow at a CAGR of 12.53% from 2023 to 2030, according to a new report published by Verified Market Research®. The report reveals that the market was valued at USD 55.40 Billion in 2022 and is expected to reach USD 168.34 Billion by the end of the forecast period.
Download PDF Brochure: https://www.verifiedmarketresearch.com/download-sample?rid=4857
Browse in-depth TOC on “Cloud ERP Market”
202 – Pages
126 – Tables
37 – Figures
Global Cloud ERP Market: Transformative Growth Fueled by Digital Shift and Construction Industry Adoption
The Global Cloud ERP Market is experiencing unprecedented growth driven by the worldwide digital transformation wave and accelerated adoption within the construction industry. Cloud ERP, a robust and flexible enterprise resource planning solution accessible over the internet, has revolutionized the business landscape. This cloud-based software automates critical operational and financial functions, providing organizations with a unified source of data, order management, supply chain optimization, procurement, production, distribution, and fulfillment capabilities.
Cloud ERP Market Drivers:The market surge is powered by transformative technologies, particularly cloud-based solutions, reshaping business interactions, innovation processes, and data analytics. Cloud ERP empowers organizations to integrate cutting-edge technologies, fostering innovation and sustainable Cloud ERP Market growth. The construction industry’s swift adoption, driven by the opportunities presented during the Covid-19 pandemic, has further accelerated the market’s expansion. Construction companies are leveraging Cloud ERP to stabilize operations and recapture growth opportunities lost during the crisis.
Cloud ERP Market Outlook:The Global Cloud ERP Market is poised for substantial growth, with North America leading the charge. The region boasts a robust technology landscape and hosts a multitude of key Cloud ERP vendors. The market is set to witness continuous expansion, driven by the evolving digital business environment and the construction industry’s ongoing technological transformation efforts.
Key Players and Competitive Landscape:In the competitive landscape of the Global Cloud ERP Market, key players are deploying innovative strategies to secure their market positions. Market ranking analysis reveals the dominance of established vendors, leveraging their expertise to capture significant market shares. Continuous market share analysis highlights the dynamic nature of the industry, encouraging players to engage in key development strategies to maintain their competitive edge.
Cloud ERP stands as a cornerstone in modern business strategies, enhancing operational efficiency, fostering innovation, and offering unparalleled scalability. The market’s trajectory is marked by relentless innovation and strategic moves by key players, shaping the future of enterprise resource management.
To get market data, market insights, financial statements and a comprehensive analysis of the Global Cloud ERP Market, please Contact Verified Market Research®.
Based on the research, Verified Market Research® has segmented the global Cloud ERP Market into Component, Organization Size, End-User, And Geography.
Cloud ERP Market, by ComponentSolutionServicesCloud ERP Market, by Organization SizeLarge EnterprisesSmall and Medium-sized EnterprisesCloud ERP Market, by End-UserBFSIIT & TelecomHealthcareGovernment and Public SectorAerospace and DefenseRetailOthersCloud ERP Market, by GeographyNorth AmericaU.SCanadaMexicoEuropeGermanyFranceU.KRest of EuropeAsia PacificChinaJapanIndiaRest of Asia PacificROWMiddle East & AfricaLatin AmericaBrowse Related Reports:
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Top 5 Cloud Managed Services using internet to deliver applications
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