Artificial Intelligence
AvenCell Announces First Patient Dosed in a Phase IA Study with lead product candidate AVC-201, a Novel Allogeneic CD123-Directed Switchable CAR-T Investigational Therapy for the Treatment of Relapsed/Refractory Acute Myeloid Leukemia and other CD123 Hematological Malignancies
AVC-201 is the world’s first CRISPR-engineered switchable allogeneic CAR-T designed to fully avoid rejection by both the innate and adaptive host immune system.
WATERTOWN, Mass., Feb. 6, 2024 /PRNewswire/ — AvenCell Therapeutics, Inc., a leading clinical-stage cell therapy company focused on advancing both autologous and allogeneic switchable CAR-T cell therapies, today announced that it has dosed the first patient in a Phase IA study with AVC-201 for the treatment of relapsed/refractory Acute Myeloid Leukemia (AML) and other selected hematologic malignancies positive for CD123 (NCT05949125). AVC-201 is a CRISPR-engineered allogeneic switchable CAR-T candidate designed to target and eliminate cells expressing receptor CD123, which is known to be overexpressed in nearly all acute myeloid leukemias, and several other hematological malignancies.
“Patients with AML with minimal residual disease or who progress after currently available treatment approaches generally have a very poor prognosis and limited options,” said Professor Martin Wermke, Head of the Early Clinical Trial Unit at the National Cancer Center Dresden, Germany. “AvenCell’s autologous switchable CAR-T therapy has already yielded highly promising early clinical results in AML treatment. AVC-201, a readily available donor-derived allogeneic cell product is expected to reach the patients in need much faster at substantially lower cost.”
The phase 1 study, which includes up to 37 patients, will be conducted at multiple sites in Germany and the Netherlands. The primary objective of the trial is to assess the safety profile of AVC-201 and to determine the maximum tolerated dose. Secondary measures will include efficacy, safety, and CAR-T persistence.
“We are excited to build on the safety and promising activity observed in our ongoing autologous switchable clinical study in AML (AVC-101) by now implementing what we believe is the most scientifically-compelling allogeneic technology in the industry,” said Andrew Schiermeier, AvenCell’s President & CEO. “We are the first company to combine a Switchable CAR-T with an off-the-shelf solution for broad applications across cancer and autoimmune indications. This modular approach allows for unparalleled future flexibility and reduction in cycle times, massive scaling of supply, and meaningful reductions in cost of goods, all of which will dramatically advance the field of cell therapy for patients.”
About AVC-201AVC-201 is a CRISPR-edited Chimeric Antigen Receptor (“CAR”)-T Cell therapy that embodies two discrete technology platforms. The first leverages AvenCell’s “UniCAR” universal/switchable technology which is comprised of a two-component system. Engineered T Cells are transduced with a “universal” receptor that is completely biologically inert (expressing human La peptide) and are only activated when bound to a second biologic molecule (“targeting module”) which directs the T cells to a cancer antigen of interest (in this case, CD123). The presence or absence of the targeting module in circulation allows for exquisite “on” and “off” control, respectively, of the therapeutic activity. The second technology platform consists of an in-licensed allogeneic cell engineering technology developed by Intellia Therapeutics which allows for unrelated donors to provide cells for patients. These cells are uniquely engineered via CRISPR/Cas9 to avoid GvHD and rejection via the host/patient immune system by either innate or adaptive mechanisms.
About AVC-201 Clinical ProgramAvenCell’s Phase I study (NCT05949125) is evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of AVC-201 in adults with relapsed or refractory AML and other CD123 positive hematological malignancies. The study is an open-label, single-ascending dose design used to identify a cell and targeting module dose level combination of AVC-201 that will be further evaluated in a subsequent Phase 2 study.
About Acute Myeloid Leukemia (AML)AML typically develops from mutations in the DNA of early blood-forming cells, leading to the disruption of normal cell maturation and proliferation. This results in a buildup of immature cells in the bone marrow, crowding out healthy cells and impairing their ability to function properly. AML accounts for a significant proportion of all leukemia cases. Approximately 21,000 new cases of AML are diagnosed in the United States per year, while on a global scale, the incidence of AML is estimated to be around 2-8 cases per 100,000 people annually. Treatment for AML usually involves chemotherapy to destroy cancer cells, and more recently available targeted therapies directed against specific mutations (e.g. IDH, FLT3.) While most AML cells express the receptor CD123, several previous attempts to target this receptor therapeutically have failed due to the difficulty in managing toxicity. AVC-201 addresses this limitation by implementing a rapid on/off switch via dosing of targeting module. Stem cell transplant continues to be considered the only curative option. The survival rate of AML can vary depending on several factors, including age, overall health, specific genetic mutations, response to treatment, and other individual characteristics. However, the overall five-year survival rate for AML is around 25-30%.
About AvenCell TherapeuticsAvenCell derives its name from the French word “avenir” to reflect the aim to be the FUTURE of cell therapy. AvenCell is building a truly transformative cell therapy company that targets difficult-to-treat cancers, with its lead programs focusing on acute myeloid leukemia (AML) and prostate cancer, and additional programs targeting other hematological malignancies and solid tumors. AvenCell was formed with the goal to create truly allogeneic cells that persist as long or longer than autologous therapies and develop a universal and switchable construct that allows complete control and target redirection of T cells after they are infused into a patient. Integration of these two platforms allows for complete separation of the manufacturing of cells from ultimate patient and cancer target, thus providing significant scalability potential at orders of magnitude more efficient than current approaches.
AvenCell Therapeutics, Inc. was launched in 2021 by Blackstone Life Sciences, Cellex Cell Professionals, and Intellia Therapeutics, and incorporated the clinical-stage biopharmaceutical company GEMoaB GmbH. AvenCell is headquartered in Watertown, Massachusetts with additional R&D and manufacturing operations in Dresden, Germany. AvenCell Europe GmbH is sponsor of the AVC-201 study.
For more information, visit www.avencell.com.
Follow AvenCell on social media: LinkedIn.
Forward-Looking StatementsThis press release contains “forward-looking statements” of AvenCell Therapeutics, Inc. (“AvenCell” or the “Company”) within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements include, but are not limited to, express or implied statements regarding AvenCell’s beliefs and expectations regarding: the safety, efficacy, success and advancement of its clinical program for AVC-201 for the treatment of CD123 positive hematological malignancies pursuant to its clinical trial applications, including the initiation, enrollment, dosing and completion of clinical trials, such as planned enrollment for the Phase 1 portion of the study for AVC-201.
Forward-looking statements involve substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Risks and uncertainties include, among other things, the uncertainties inherent in research and development, including AvenCell’s ability to initiate, progress or complete pre-clinical or clinical studies within currently anticipated timelines or at all, and the possibility of unfavorable results from ongoing or additional pre-clinical or clinical studies; uncertainties relating to regulatory applications and related filing and approval timelines; risks related to AvenCell’s relationships and collaborations with third parties; risks related to the maintenance and protection of AvenCell’s intellectual property; risks related to the potential successful development and commercialization of AvenCell’s product candidates; and risks associated with AvenCell’s understanding of cell therapy and its application to the treatment of cancers.
All statements other than statements of historical fact are statements that could be deemed forward-looking statements. The reader is cautioned that any such forward-looking statements are not guarantees of future performance and involve risks and uncertainties and is cautioned not to place undue reliance on these forward-looking statements. All forward-looking statements are based on information currently available to AvenCell, and AvenCell assumes no obligation and disclaims any intent to update any such forward-looking statements.
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ContactConstanze Medack+49 351 44664500 [email protected]
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Artificial Intelligence
Hyperview Revolutionizes Data Center Management with Advanced DCIM Suite
New Carbon Footprint Reporting Delivers Unmatched Insights, Optimizing Sustainability and Performance
VANCOUVER, British Columbia, Oct. 9, 2024 /PRNewswire/ — Hyperview, the leading cloud-based data center infrastructure management (DCIM) platform, today unveiled a suite of groundbreaking features set to transform data center management through detailed measurement and comprehensive sustainability tools.
At the heart of this is Hyperview’s new carbon footprint reporting system, providing granular insights that surpass traditional location-based methods. The initial offering provides location and rack-level carbon footprint reporting, with future releases set to include carbon footprint reporting down to the asset level. This phased approach enables a level of detailed analysis previously unseen in the industry, allowing for more informed, impactful operational decisions. By offering a holistic view of a data center’s environmental impact, from equipment performance to overall energy consumption, Hyperview is setting a new standard for sustainability management in the digital infrastructure sector.
“The timing of this release is crucial”, says President and CEO Jad Jebara. “As the data center industry faces mounting pressure to address its environmental impact. Data centers currently consume 1.5% of the global energy supply and emit 59 million metric tonnes of CO2 annually. Without significant intervention, experts project this consumption could skyrocket to 8% by 2030. Hyperview’s solutions enable targeted reduction strategies, addressing inefficiencies in IT equipment management and providing detailed emissions analysis.”
Key Highlights:
Phased Reporting Implementation: Initial offering includes location and rack-level carbon footprint reporting, with asset-level insights coming in future releases.Asset-Level Analysis: Enables impactful decision-making through detailed equipment, material, and power data.Predictive Capabilities: Offers current data and future predictions, surpassing competitors’ reliance on historical information.Cost-Effective Solution: Eliminates need for additional professional services through automated data collection and presentation.Regulatory Compliance: Assists in navigating evolving regulations (SB 253, CSRD, EED) while improving ESG performance.Comprehensive Sustainability Tools:Carbon footprint tracking and managementUnlocking stranded power and cooling capacityMonitoring energy usage efficiency and kilowatt hours at rack-levelSetting rack-level thresholds for power and temperatureMonitoring temperature, Delta-T, and humidity”Hyperview’s precision in digital infrastructure management is akin to diagnosing a specific medical condition rather than broadly identifying an illness,” continues Jebara “While competitors might broadly identify issues, Hyperview pinpoints specific causes, enabling our clients to make targeted improvements, significantly reducing their carbon footprint and operational costs.”
These features allow clients to gain a detailed understanding of their energy consumption and identify areas for improvement, contributing to significant carbon footprint reductions. The platform’s detailed data helps clients understand their current situation and make accurate future predictions.
With this advanced DCIM suite, Hyperview reaffirms its position as a leader in data center management solutions, offering unparalleled tools for sustainability, efficiency, and regulatory compliance. As the industry evolves, Hyperview remains at the forefront, driving innovation and enabling data centers to meet the challenges of tomorrow.
To experience Hyperview’s Carbon Footprint Reporting firsthand, schedule a demonstration at https://www.hyperviewhq.com/carbon-footprint/
About Hyperview
Hyperview is the leading cloud-based data center infrastructure management (DCIM) platform that empowers enterprises to optimize capacity, reduce power and energy consumption, lower costs, and avoid outages. The powerful and easy-to-use platform includes Asset Management, Energy Management, Power and Environmental Monitoring, Capacity Planning, and 3D Visualization. Learn more at www.hyperviewhq.com.
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Artificial Intelligence
Recorded Future Unveils AI-Driven Enhancements to Combat Ransomware Threats with Real-Time Intelligence
AI-Powered Threat Intelligence Delivers Enhanced Visibility, Faster Detection, and Proactive Response Across the Entire Ransomware Lifecycle
BOSTON, Oct. 9, 2024 /PRNewswire/ — Recorded Future, the world’s largest threat intelligence company, today announced new industry-first ransomware detection capabilities to proactively address threats across the entire attack lifecycle. These capabilities provide real-time visibility into the most pressing and unique risks facing organizations, including ransomware group operations and targeted victims within their specific ecosystems. Powered by Recorded Future AI, organizations receive automated, customized ransomware intelligence with AI-driven reporting, providing timely, actionable insights as an extension of their security teams.
Ransomware continues to rank as the top cybersecurity threat, with attacks rising over 70% in 2023 and $1 billion paid in ransoms. Attackers are shifting further from simple data encryption to more sophisticated extortion tactics, forcing organizations to deal with financial losses, operational disruptions, and reputational damage. Despite major investments in cybersecurity, early detection continues to be a challenge, leaving networks exposed to ransomware. Recorded Future strengthens defenses in areas where EDR, MFA, and other detection tools fall short, providing critical coverage for more complete protection. To address these issues, Recorded Future is enhancing its existing capabilities to offer more comprehensive visibility, real-time insights, and early-stage threat detection through new features:
Ransomware Risk Profiles: Organizations can now monitor customized ransomware risk profiles that offer an end-to-end view of ransomware exposure, that are specific to their organization, helping to identify vulnerabilities and potential attack surface risks early. This empowers security teams to prioritize action and address threats before they escalate.Victimology & Actor Insights: Recorded Future provides real-time insights into ransomware groups’ activities, their victims, and targeted sectors such as specific industries, geographies, or supply chains. These insights are based on MITRE ATT&CK mappings and deep research from Recorded Future’s Insikt Group, enabling security teams to better understand threat actor operations and make proactive defense decisions.AI-Generated Reporting: With the power of Recorded Future AI, organizations can now automatically generate detailed, audience-specific ransomware intelligence reports. These reports provide leadership and security teams with timely, actionable insights, reducing manual effort and accelerating decision-making.”Recorded Future’s AI-powered Intelligence Cloud allows us to take a proactive stance to combating ransomware actors. With Recorded Future’s Threat Intelligence module we will be able to produce reports using AI Reporting with actionable insights on the highest priority threats to inform stakeholders across the organization. This will help us know how to best protect our organization, and increase our resilience.” – Jeremy Miller, Cyber Threat Intelligence Analyst, Nelnet
Ransomware attacks represent a complex and evolving challenge for organizations today. Despite extensive investments in detection tools, security teams often lack the visibility and early detection needed to thwart attacks. Recorded Future’s enhanced Threat Intelligence Module provides organizations with comprehensive visibility across the ransomware lifecycle, empowering them to take a proactive approach to defending against ransomware thereby improving resilience, and mitigating the financial, operational, and reputational damage caused by these attacks.
“While proactive defense and resilience to ransomware attacks are achievable with the right intelligence, an AI-driven approach puts security teams ahead of their adversaries’ next move. We’ve looked at the ransomware lifecycle and applied Recorded Future AI, combined with our threat intelligence and client telemetry, to create a single source of truth, defeating ransomware early for each one of our clients.” – Dr. Christopher Ahlberg, Co-founder and CEO, Recorded Future
For more information or to request a demo, visit: https://www.recordedfuture.com/outcomes/ransomware
To learn more about Recorded Future’s Ransomware Detection Capabilities, visit:https://www.recordedfuture.com/blog/enhanced-ransomware-solution-announcement
About Recorded FutureRecorded Future is the world’s largest threat intelligence company. Recorded Future’s Intelligence Cloud provides end-to-end intelligence across adversaries, infrastructure, and targets. Indexing the internet across the open web, dark web, and technical sources, Recorded Future provides real-time visibility into an expanding attack surface and threat landscape, empowering clients to act with speed and confidence to reduce risk and securely drive business forward. Headquartered in Boston with offices and employees around the world, Recorded Future works with over 1,800 businesses and government organizations across more than 75 countries to provide real-time, unbiased and actionable intelligence. Learn more at recordedfuture.com.
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Artificial Intelligence
IMPROVATE brings the world’s most advanced smart city technology from Israel to all over the world
An international “smart cities” powerhouse
BUDAPEST, Hungary, Oct. 9, 2024 /PRNewswire/ — IMPROVATE brought together 15 major cities from across Europe for a Smart Cities conference in Budapest, during which the cities were introduced to the latest and most advanced technological developments by leading Israeli companies in the field, including – Tondo Smart, Juganu, Gadfin, IPlus Cyber, IPgallery, Ok2go, Wise Mon, Atmosfir, Giv Solutions, Ortech , Safer Place, Raizit, Galileo Navigation.
Ronit Hassin Hochman, CEO of IMPROVATE: “Even while the State of Israel is facing a multi-front conflict, the Israeli high-tech industry continues to lead in innovation and technology, helping to maintain the resilience of the Israeli economy.”
The conference, held this week at the Ritz-Carlton in Hungary’s capital, was attended by representatives and mayors of prominent cities across Europe, including Budapest, Sofia, Larnaca, Skopje, Tirana, and others.
While Israel is fighting on multiple fronts, the local high-tech industry continues to achieve outstanding results and maintain the resilience of the Israeli economy. This week, the IMPROVATE Smart Cities Conference took place in Budapest, Hungary. It brought together leading mayors from across Europe.
The aim of the conference was to introduce the world to new and advanced technologies in the field of “smart cities” developed by the Israeli high-tech industry. The mayors met with the leading and most innovative Israeli companies in the field, with the goal of getting to know and implementing new technologies for city management in the cities they govern. Among the Israeli companies that participated in the conference are:
Juganu
Juganu transforms physical spaces into smart, digitized environments through its AI-driven platform that is simple to deploy. By replacing existing light fixtures, Juganu creates adaptable smart spaces that collect and process data, empowering organizations to efficiently manage, monitor, and evolve their environments for future needs.
Ortech
Ortech Defence Systems Ltd. specializes in protection and hardening of existing structures, providing mobile shelters, and developing innovative applications based on composite materials for protection against explosions, blast waves, and shrapnel. The company offers modular protection solutions, comprehensive Turnkey services, survivability reports, and field testing – all to deliver a professional and complete solutions for structural and strategic site protection needs. Ortech has leading protection systems that are Home Front Command approved, including the Ortech Safe Room system, which protects existing rooms in homes and apartments without a secure shelter for emergency situations.
Safer Place
Safer Place unique video based technology platform enables police, municipalities and law enforcement agencies to streamline traffic enforcement operations, increase road safety, drive productivity and generate surplus revenue from traffic and parking fines focusing on life risking traffic violations.
With over 12 years’ experience in the traffic enforcement domain, Safer Place has gained a solid reputation as a trusted solution provider based on dozens of large-scale installations for Tier 1 municipal authorities and police organizations in EMEA including Tel Aviv municipality, Jerusalem municipality, Ayalon Highways, Napels Police, Torino Police and more.
Clean2Go
Clean2Go proudly participated in the Smart Cities Conference in Budapest, showcasing its innovative platform that centralizes waste collection and street cleaning services into one comprehensive system.
With advanced AI capabilities, Clean2Go enhances data accuracy and operational efficiency, making cities smarter and cleaner. During the event, we engaged with deputy mayors from Larnaka, Nikola Barbutov from Sofia, and other cities, as well as key integrators, to explore collaborative opportunities for improving urban management.
Tondo Smart
Tondo Smart develops smart outdoor lighting solutions that serve as a platform for a data-driven, smart public space. With Tondo’s system, cities can add and manage applications that use AI insights to optimize public space management, making it more efficient, eco-friendly, and user-friendly for residents. Tondo Smart develops smart outdoor lighting solutions that serve as a platform for a data-driven, smart public space. With Tondo’s system, cities can add and manage applications that use AI insights to optimize public space management, making it more efficient, eco-friendly, and user-friendly for residents.
Raizit
Raizit is a startup company that develops and operates the leading digital public participation platform in Israel. The platform has been chosen by most government ministries, including the Ministries of Health, Education, Justice, Labor, Prime Minister’s Office, and more. It has also been adopted by statutory authorities such as the Tax Authority, Planning Administration, Water Authority, and others, as well as municipalities like Tel Aviv, Herzliya, Netanya, and more. Raizit’s clients engage in qualitative and meaningful communication with their stakeholders through questionnaires, surveys, online discussions, and innovative tools like participatory maps. The system analyzes the results using a unique AI model, producing accurate and rapid conclusions and recommendations.
Wise-Mon LTD
Wise-Mon Ltd specializes in network cyber solutions, providing a Next generation NAC for securing networks and IOT devices. The company has dozens of clients in Israel and abroad in various sectors of the economy. As part of the Smart Cities Conference, the company presented TruNAC – their flagship product.
Galileo Navigation
Galileo indoor turn by turn GPS navigation and data collection. Saving time, saving money, making money and saving lives.
Iplus Cyber
Many cities are increasingly vulnerable to cyber threats, yet often lack the budget for top-tier security measures. At I Plus Cyber, we created Attackwatch to empower municipalities in safeguarding their critical infrastructure. Our solution offers advanced threat intelligence, breach detection, and attack surface management—all at an affordable price—ensuring the protection of the communities they serve.
IPgallery
IPgallery delivers AI-driven software solutions, enhancing urban life. Our technologies, designed for safety, sustainability, and resilience, provide vital tools for managing daily operations and emergencies. We empower city stakeholders across interconnected sectors including transportation and mobility, environment, air quality, citizen engagement, power and energy, public safety, and urban planning.
GIV-solutions
Established in 2021, GIV-solutions is among the world’s leading Asset intensive management software solution providers, with over twenty years of experience in delivering large-scale software projects for the Smart city, transportation, Health care, campus, energy and real estate sectors.
GIV-CITY™ offers a powerful and holistic management system – the digital brain and beating heart of the smart city. By consolidating disparate data sources into a single unified platform, GIV-CITY™ ensures seamless communication and compatibility among different systems and devices. It empowers city officials to collaborate, make timely, data-driven decisions, minimize risks, and continuously improve management processes and government transparency.
Atmosfir
Atmosfir, an Israeli R&D integrator for advanced environmental solutions, presented HaZapp, a social application for reporting and managing environmental hazards globally, covering all types of hazards.
Additionally, the company introduced the D-fenceline system, which measures air pollutants in real-time along the fences of chemical plants, under ISO 17025 accreditation.
Gadfin
Gadfin Aerologistics System develops, manufactures and operates long range (>250Km), Heavy duty (8-150Kg), unmanned eVTOL’s for B2B logistics. Gadfin has an unprecedented backlog of orders reaching more $350M. The biggest in its segment.
Among the cities that participated were prominent cities in Central and Eastern Europe, including Larnaca in Cyprus, Sofia in Bulgaria, Burgas, Plovdiv, Vratsa, and more.
Ronit Hassin Hochman, CEO of IMPROVATE: “Even while the State of Israel is in a multi-front conflict, the Israeli high-tech industry continues to lead in innovation and technology, helping to maintain the resilience of the Israeli economy. Israel is becoming a global power in the field of ‘smart cities,’ and today’s conference demonstrates its strength, as mayors from across the continent come to be exposed to, learn, and implement Israeli technologies in major European cities.”
Larnaca Mayor, Andreas Vyras, said at the conference: “The IMPROVATE Smart Cities conference is an excellent opportunity for us to enter the field of smart cities, which we have been aiming for for a long time. Additionally, the opportunity to collaborate with Israeli companies in the field intrigued us, and we hope to start cooperation between the parties.” On the conference content, the Larnaca Mayor said: “Participation in the professional panels allowed us to present the challenges we face, such as smart transportation, waste management, traffic, and cybersecurity, and to begin to learn and become familiar with the systems and developments that can help us deal with these challenges.”
The field of “smart cities” is one of the fastest-growing and most significant fields in technology and innovation today. More and more cities around the globe are implementing advanced technologies based on artificial intelligence or big data to improve the quality of life, safety, and security of their residents. As a result, the field is experiencing remarkable growth, with estimates suggesting there are currently thousands of active smart city projects worldwide. From major cities like Barcelona, New York, Tel Aviv, and Stockholm, which have technological systems helping manage and improve the lives of millions of residents, to smaller communities implementing smart technologies to address various urban challenges. Consequently, global investments in the field are expected to break records in the coming years, turning it into a market estimated to be worth tens of billions of dollars.
Alongside technological success comes economic growth
Investments in the field of smart cities continue to grow rapidly, becoming a global magnet for investors and technology companies recognizing the need and potential of smart technologies to improve quality of life in cities. In light of all this, it is estimated that in the coming decade, the number of new cities worldwide expected to implement smart city systems will increase significantly. The prominent fields leading this area include traffic and public transportation management, renewable energy, and systems for reducing crime and enhancing personal security.
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