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Basecamp Research launches ZymCTRL a world-first, open source, generative AI tool that designs enzymes for more sustainable industrial processes

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ZymCTRL is the world’s first open-source, text-based enzyme generation model and can be used across multiple industries, including therapeutics and sustainability initiatives.
AI model able to produce sequences that produced functional enzymes with desirable characteristics for industrial applications.
LONDON, June 18, 2024 /PRNewswire/ — Basecamp Research, a world leader in artificial intelligence (AI)-based design of proteins and other biological systems, in partnership with the Ferruz Laboratory at the Institute of Molecular Biology of Barcelona today announced the release of ZymCTRL (“enzyme control”), a ChatGPT-like tool that generates new sequences from scratch based on a user simply typing in an enzyme identification code, which specifies the desired activity.

Large language models (LLMs), such as ChatGPT, have proven useful in helping scientists design and generate protein sequences.. However, current models require further training as well as conditioning on a known protein starter sequence (“seed sequence”) for protein generation.
ZymCTRL is a next-generation end-to-end protein LLM that offers rapid, cost-effective design capabilities for generating artificial enzymes. In contrast to other LLMs, the tool requires no seed sequence, giving end users complete control. Another important feature is ZymCTRL’s ability to create enzyme sequences that work but share only 30% resemblance to those in the training set – expanding the possibilities for designing new enzymes.
“With ZymCtrl, generating highly specific enzymes is as easy as interacting with a chatbot”, said Noelia Ferruz who has been partnering with Basecamp Research for over 2 years. The Ferruz lab is considered a pioneer in the field of AI for protein design, having previously built ProtGPT2. a deep unsupervised language model for protein design.
“Even before the release of ChatGPT,  we began working on large language models with Noelia because we think these models represent the future of biological research and protein design,” said Dr. Philipp Lorenz, CTO of Basecamp Research. “We’re deeply excited by these results and ZymCTRL’s ability to create functional enzymes that can solve some of today’s biggest challenges, from finding new ways to treat devastating diseases to building greener and more sustainable catalytic processes in bioindustry.”
The open source ZymCTRL model has been independently reviewed by academics in Structural Biology and ChemBioChem, peer-reviewed scientific journals. In ChemBioChem, researchers at The Institute of Biochemistry at Austria’s Graz University of Technology, cited ZymCTRL’s efficiency and ease of use. “ZymCtrl designs putative enzyme variants on consumer GPUs within seconds and, remarkably, it creates these sequences with only an EC number as input,” wrote Horst Lechner, principle investigator for the institute, which is focuses on enzyme design that differs from what’s seen in nature.
Basecamp Research is sharing ZymCTRL open source with researchers and sees an array of potential applications, including designing enzymes for disease treatment and diagnostics, biofuel production, sustainable agriculture innovations and much more.
While ZymCTRL was initially trained on publicly available datasets, it can also be integrated with other datasets, including Basecamp Research’s proprietary BaseGraph database, to further optimise the model and improve sequence outputs.
Highlights
ZymCTRL was first trained on the BRENDA enzyme database, comprising 37M enzyme sequences.- From this, the team generated sets of carbonic anhydrases, enzymes that accelerate the conversion of carbon dioxide to bicarbonate, helping capture and store CO2, and lactate dehydrogenases, enzymes that help convert sugar into energy in our cells, with no further fine-tuning for the AI model.After producing and purifying the proteins, several showed enzyme activity despite less than 40% of their sequences resembling proteins seen in the public database. This happened with no additional adjustments to the model.- To correct for potential biases in public databases, which have uneven sampling due a lack of biodiversity, ZymCTRL was adjusted using a wider range of lactate dehydrogenase sequences from Basecamp Research’s proprietary BaseGraph dataset.- With this fine-tuning, the team created lactate dehydrogenases with higher quality scores in silico (in computer simulations), such as better predicted local distance difference test (pLDDT) values, compared to sequences generated with no prior training.Remarkably, active enzymes continued to show significant activity at a high temperature of 45°C as well as across a broad pH range of 4.5 to 9.5 – meaning it can work or stay stable in slightly acidic to slightly basic environments – offering significant industry advantages over naturally-occurring lactate dehydrogenases. This excellent pH tolerance allows a single enzyme to be used in many different processes with different pH levels, making the enzyme very useful and adaptable for many applications.Two of the artificial lactate dehydrogenase enzymes were produced in larger amounts and successfully freeze-dried. They kept their activity and showed they could work in complex reactions under harsh conditions, supporting their potential for industrial use.”Beyond the obvious excitement of being able to generate truly de novo proteins, the results are a further testament to the ability of Basecamp Research’s dataset to produce better results compared to publicly available datasets, which barely scratch the surface of the Earth’s immense biodiversity,” added Dr. Glen Gowers, co-founder of Basecamp Research. “Earlier we were able to show that our BaseFold model, also powered by our dataset, outperformed AlphaFold2 in predicting protein structures. Generative AI is going to have a huge impact across biotech, and we’re dedicated to collecting the data and tools needed to make its potential a reality.”
The full preprint can be found here: https://www.biorxiv.org/content/10.1101/2024.05.03.592223v1
Basecamp Research invites the research community to try ZymCTRL and has released it for public use on Hugging Face: https://huggingface.co/AI4PD/ZymCTRL
For media and other inquiries, please contact [email protected], +44 07867 488769
About Basecamp Research
Basecamp Research is a leader in mapping biodiversity for AI-based design of biological systems. We match and refine novel proteins for our partners’ exact industrial, therapeutic or diagnostic applications using BaseGraph™, a new generation of AI design that is powered by the first-ever high-resolution map of global genetic biodiversity. 
Understanding the full genetic, evolutionary, and environmental context of each protein allows Basecamp Research to design tailored proteins for specific applications without the need for expensive and time-consuming directed evolution campaigns. We’re a team of explorers, scientists and policy experts driven by our ambition to protect and learn from nature’s diversity, whilst delivering life-changing breakthroughs to those who need them most. 
For more information, visit www.basecamp-research.com.
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Artificial Intelligence

Medasense Announces a Strategic Agreement With Global Medical Company, Nihon Kohden Corporation

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RAMAT GAN, Israel, June 26, 2024 /PRNewswire/ — Medasense, a global leader in pain monitoring solutions, is proud to announce a strategic partnership with Nihon Kohden for the exclusive distribution of its revolutionary pain monitoring device in Japan. This partnership is intended to transform pain management practices across Japanese healthcare facilities, offering a significant advancement in patient care.

 
Nihon Kohden, renowned for its history of excellence in providing innovative high quality, reliable medical technology that improves the way healthcare is practiced, is partnering with Medasense to introduce its nociception monitor to the Japanese market. This cutting-edge device, with its state-of-the-art AI powered NOL – Nociception Level Index®, provides real-time, objective pain monitoring, enabling the personalization and optimization of pain treatment. It will be accessible to hospitals and clinics throughout Japan through Nihon Kohden’s extensive distribution channels pending regulatory approval.
Medasense’s CEO & Founder, Galit Zuckerman, expressed enthusiasm about the collaboration: “We are honored to partner with Nihon Kohden, a company with a long history of excellence, that shares our vision of improving patient care through innovative solutions. Our mission is to help all patients suffer less from pain and the adverse effects of pain medication. Nihon Kohden’s established clinical, technological leadership and expertise in the Japanese market make them the perfect partner to distribute our nociception monitor.”
NOL monitoring provides an AI powered, clinically validated index to objectively quantify the physiological response to pain (nociception) supporting clinicians in delivering personalized anesthesia tailored to patient requirements. With over 40 peer reviewed publications, clinical studies have demonstrated that NOL-guided analgesia resulted in intraoperative opioid sparing, and improved post operative pain scores and patient recovery.1,2
For more information about Medasense and Nihon Kohden, please visit www.medasense.com and www.nihonkohden.com/.
About Medasense and NOL – Nociception Level Index® Technology
Medasense is transforming pain management with its breakthrough technology that empowers clinicians to optimize and personalize pain control, significantly reducing the risk of pain or of overmedication. The company’s flagship product, the PMD-200™, equipped with the NOL-Nociception Level Index®, leverages advanced artificial intelligence and a proprietary non-invasive sensor system. This unique platform provides objective monitoring and quantification of a patient’s pain response, making it an essential tool in an operating room and critical care unit settings where patients cannot communicate their pain levels. The PMD-200 is the first and only monitor to be authorized by the FDA for pain measurement for anaesthesiology. It has been used in over 100,000 surgeries worldwide, and is commercially available in the US, Europe, Canada, Latin America and Israel.
Watch Medasense’s 1-minute video
About Nihon Kohden
Founded in 1951, Nihon Kohden is a global leader of medical solutions with the goal to improve healthcare with advanced technology. For more than 70 years, Nihon Kohden has continued to provide a wide range of medical electronic equipment including EEG, EMG/EP measuring systems, electrocardiographs, bedside monitors, defibrillators, AEDs, ventilators, and hematology instruments.
Nihon Kohden utilizes cutting-edge technology to support medical treatment in all clinical areas, integrating medical devices into the IT network to meet customers’ requirements and offers a wide, comprehensive solution.
For further information please contact:Rachel Weissbrod, VP Clinical & Market Development, [email protected] 
1.  Meijer, F., Honing, M., Roor, T., Toet, S., Calis, P., Olofsen, E., Martini, C., van Velzen, M., Aarts, L., Niesters, M., Boon, M., Dahan, A. (2020). Reduced postoperative pain using Nociception Level-guided fentanyl dosing during sevoflurane anaesthesia: a randomised controlled trial. British Journal of Anaesthesia, In Press. DOI:https://doi.org/10.1016/j.bja.2020.07.057
2.  Fleur S. Meijer, Chris H. Martini, Suzanne Broens, Martijn Boon, Marieke Niesters, Leon Aarts, Erik Olofsen, Monique van Velzen, Albert Dahan. Nociception-guided versus Standard Care during Remifentanil–Propofol Anesthesia: A Randomized Controlled Trial. Anesthesiology (2019); 130:745–755
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IoT Sensors Market Set to Surpass USD 107.74 Billion by 2031| SkyQuest Technology

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WESTFORD, Mass., June 26, 2024 /PRNewswire/ — According to SkyQuest, the global IoT Sensors Market size was valued at USD 11.20 Billion in 2022 and is poised to grow from USD 14.40 Billion in 2023 to USD 107.74 Billion by 2031, at a CAGR of 28.60% during the forecast period (2024-2031).

IoT sensors are sensors that are specifically designed for Internet of Things (IoT) devices and applications. High adoption of IoT devices and growing advancements in IoT technologies are fostering demand for novel IoT sensors. The global IoT sensors market is segmented into sensor type, vertical, and region.
Download a detailed overview:
https://www.skyquestt.com/sample-request/iot-sensors-market
IoT Sensors Market Overview: 
Report Coverage 
Details 
Market Revenue in 2023 
$ 14.40 billion 
Estimated Value by 2031 
$ 107.74 billion 
Growth Rate 
Poised to grow at a CAGR of 28.60% 
Forecast Period 
2024–2031 
Forecast Units 
Value (USD Billion) 
Report Coverage 
Revenue Forecast, Competitive Landscape, Growth Factors, and Trends 
Segments Covered 
Sensor Type, Network Technology, and Vertical
Geographies Covered 
North America, Europe, Asia Pacific, Middle East & Africa, Latin America
Report Highlights 
Updated financial information / product portfolio of players 
Key Market Opportunities 
Proliferation of Smart Devices
Key Market Drivers 
Advancements in Wireless Communication Technologies
Segments covered in IoT Sensors Market are as follows:
Sensor TypeTemperature Sensor, Pressure Sensor, Humidity Sensor, Flow Sensor, Accelerometer, Magnetometer, Gyroscope, Inertial Sensor, Image Sensor, Touch Sensor, Proximity Sensor, Acoustic Sensor, Motion Sensor, Occupancy Sensor (Image Processing Occupancy Sensors, Intelligent Occupancy Sensors), CO2 Sensor, Other Sensors (Light sensor, Radar sensor)Network TechnologyWired (KNX, LonWorks, Ethernet, MODBUS, DALI), Wireless (Wi-Fi [Bluetooth Smart, Wi-Fi Bluetooth Smart, Bluetooth Smart / Ant+, Bluetooth 5]), ZIGBEE, Z-WAVE, NFC, RFID, ENOCEAN, THREAD, GLoWPAN, WIRELESS-HART, Frocess field bus, DECT-ULE, Others (ANT+, ISA100, GPS, Sub-Gig, and Cellular)VerticalConsumer (Home automation, Smart cities, Wearable electronics), Commercial (Retail, Aerospace and Defense, Logistics and supply chain, Entertainment, Financial Institutes, Corporate Offices), Industrial (Energy, Industrial Automation, Transportation, Healthcare, Smart agriculture)Request Free Customization of this report:
https://www.skyquestt.com/speak-with-analyst/iot-sensors-market
Pressure Sensors Keeping Up the Pressure in IoT Sensors Market
Pressure sensors are used in cars as well as industrial facilities used to make cars and are a vital part of almost all kinds of technical devices or products. Pressure sensors play a vital role in maintaining the safety of multiple operations by keeping the pressure in check and warning users when it reaches unsafe levels. High emphasis on security around the world is projected to promote the demand for pressure sensors in the future. Aerospace, healthcare, and manufacturing are some key industry verticals where demand for pressure sensors will always be high.
The rapid surge in the use of gesture-sensitive devices all over the world is promoting the demand for accelerometer sensors. From factory automation to smart homes, the use of accelerometer sensors is projected to soar high over the coming years. Rising sales of fitness trackers and gaming consoles are also estimated to bolster the demand for accelerometer sensors in the future.
Temperature sensors are also anticipated to be highly popular in multiple IoT devices owing to the surging demand for temperature monitoring and control in various applications. Temperature sensors are also highly vital in maintaining the safety of IoT devices and surroundings to avoid mishaps due to excessive increases or drops in temperatures. Other types of sensors include motion sensors, light sensors, CO2 sensors, occupancy sensors, gyroscopes, proximity sensors, etc. All these different types of sensors are highly crucial for sustained IoT sensors market growth across the forecast period and beyond, therefore investing in any of these could help market players bolster their share.
View report summary and Table of Contents (TOC):
https://www.skyquestt.com/report/iot-sensors-market
High IoT Adoption Allows Industrial Vertical to Take Crown in Revenue Generation
The use of IoT technologies in the industrial vertical is increasing rapidly, which is why this sub-segment holds prominence in the global IoT sensors market. High demand for automation and increasing use of IoT devices to achieve the same are slated to foster new opportunities for IoT sensors market players in this segment. High adoption of the Industry 4.0 trend is also helping this sub-segment boost the demand for IoT sensors. Development of smart infrastructure is also boosting the demand for IoT sensors in the commercial vertical. From healthcare to construction, multiple industry verticals are promoting the use of IoT technologies and thereby driving sales of IoT sensors as well.
Pressure sensors for IoT devices and IoT sensors for industrial verticals are projected to be highly popular. IoT sensor companies should invest in these sub-segments to get the best return on their investments. Meanwhile, new companies can experiment with other segments to find what suits the best for their business and focus on the same. As per analysts, investing in the development of novel proximity and accelerometer sensors will be highly rewarding for upcoming IoT sensor companies.
Related Reports:
Sensor Market
Internet Of Things (IoT) Market
Internet Of Things (IoT) Professional Services Market
IoT Security Market
5G IoT Market
About Us:
SkyQuest is an IP focused Research and Investment Bank and Accelerator of Technology and assets. We provide access to technologies, markets and finance across sectors viz. Life Sciences, CleanTech, AgriTech, NanoTech and Information & Communication Technology.
We work closely with innovators, inventors, innovation seekers, entrepreneurs, companies and investors alike in leveraging external sources of R&D. Moreover, we help them in optimizing the economic potential of their intellectual assets. Our experiences with innovation management and commercialization has expanded our reach across North America, Europe, ASEAN and Asia Pacific. 
Contact:Mr. Jagraj SinghSkyQuest Technology1 Apache Way,Westford,Massachusetts 01886USA (+1) 351-333-4748Email: [email protected] Our Website: https://www.skyquestt.com/
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Actian Recognized as Exemplary Vendor in Ventana Research Data Platform Buyers’ Guide

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Strength in Manageability and Customer Experience Earn Actian High Regard in Ventana Research Report
ROUND ROCK, Texas, June 26, 2024 /PRNewswire/ — Actian, the data and analytics division of HCLSoftware, today announced it was named an Exemplary vendor and Overall Leader in Manageability in Ventana Research’s 2024 Data Platform Buyers’ Guide for the Actian Data Platform. Ventana’s extensive approach to the Buyers’ Guide evaluates Operational and Analytic Data Platform vendors in seven key categories that are weighted to reflect product and customer experience.

“The launch of Actian Data Platform was a significant step forward for Actian that combined its capabilities for data integration, with the company’s operational databases and analytic databases,” said Matt Aslett, director of research at Ventana Research, now part of ISG. “Providing a single environment that can manage data across multiple clouds as well as on-premises contributed to Actian being classified as Exemplary and a Leader in Manageability in Ventana Research’s Buyers Guides for Analytic Data Platforms, Operational Data Platforms and Overall Data Platforms.”
For Operational and Analytic Data Platforms, Actian was ranked highly for customer experience alongside vendors such as Google Cloud and Salesforce. Customers praised Actian’s strong product roadmap, use cases, and references available on its website, which provide valuable insights to prospective buyers. In addition, Actian was designated as a Leader in Manageability due to its strong license, use, and audit capabilities.
“Being recognized as an Exemplary vendor and a leader in Manageability is a testament to our commitment to delivering user-friendly and robust data management solutions,” said Jennifer Jackson, Chief Marketing Officer at Actian. “We are dedicated to supporting our customers throughout their entire journey with our products, ensuring they have the tools and support they need to succeed. This recognition by Ventana Research validates our efforts and motivates us to continue enhancing our platform to meet and exceed customer expectations.”
To learn more about Actian’s designation in the report please read this blog post and download the report here. 
About ActianActian makes data easy. We deliver cloud, hybrid, and on-premises data solutions that simplify how people connect, manage and analyze data. We transform business by enabling customers to make confident, data-driven decisions that accelerate their organization’s growth. Our data platform integrates seamlessly, performs reliably, and delivers industry-leading speeds at an affordable cost. Actian is a division of HCLSoftware.
Media Contacts
Danielle LeeSenior Director – Global Analyst Relations & Public [email protected] 
Ali WheelerPublic Relations [email protected] 
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