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Nature article presents impact and importance of epithelial barrier damage on a range of common diseases

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SciBase Holding AB (“SciBase”) [STO:SCIB], a leading developer of augmented intelligence-based solutions for skin disorders, announced today the publication of a  groundbreaking article presenting the “epithelial barrier hypothesis” in Nature Reviews Immunology. The article was written by Professor Cezmi Akdis at the Swiss institute of Allergy and Asthma Research (SIAF). Prof. Akdis is the key research collaborator in SciBase’s product development for skin barrier assessment. The article presents the background for the steep increase in allergic diseases over the last decades, and how this increase is connected to industrialization and modern lifestyle.

Simon Grant, CEO of SciBase commented, “This article shows just how important the skin and epithelial barrier in general, are in the development of a range of diseases. It also illustrates the potential value of tools for epithelial barrier assessment. This week Prof Akdis and his team in Davos also published an article in Allergy on the use of Nevisense with perhaps the most common barrier-related disease, atopic dermatitis. The Nature article is impressive in its breadth and by extension what it can mean for SciBase’s barrier assessment technology. I think this will help followers of SciBase understand why we have included barrier assessment as a key component of our strategy. The article is not just important from a scientific perspective; we also believe it will, together with the previously published article in Allergy, drive interest from researchers and potential industry partners.”

Professor Akdis provides some background. “There has been a steep increase in allergic and autoimmune diseases, reaching epidemic proportions and now affecting more than one billion people worldwide. These diseases are more common in industrialized countries, and their prevalence continues to rise in developing countries in parallel to urbanization and industrialization. Intact skin and mucosal barriers are crucial for the maintenance of tissue homeostasis as they protect host tissues from infections, environmental toxins, pollutants and allergens.

A defective epithelial barrier has been demonstrated in allergic and autoimmune conditions such as asthma, atopic dermatitis, allergic rhinitis, chronic rhinosinusitis, eosinophilic esophagitis, coeliac disease and inflammatory bowel disease. In addition, leakiness of the gut epithelium is also implicated in systemic autoimmune and metabolic conditions such as diabetes, obesity, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis and autoimmune hepatitis. Finally, distant inflammatory responses due to a `leaky gut’ and microbiome changes are suspected in Alzheimer disease, Parkinson disease, chronic depression and autism spectrum disorders.

The article introduces the `epithelial barrier hypothesis’, which proposes that the increase in epithelial barrier-damaging agents linked to industrialization, urbanization and modern life underlies the rise in allergic, autoimmune and other chronic conditions. Furthermore, it discusses how the immune responses to impaired microbiota, which normally acts as a barrier against pathogens, may be involved in the development of these diseases.

The research started in 1998 with the first studies showing mechanisms of eczema, mechanisms of epithelial cell death and continued with more than 60 publications, many major discoveries and one ready to use skin barrier detection instrument.

The articles can be found at:

Nature article: https://www.nature.com/articles/s41577-021-00538-7.

Allergy article: https://onlinelibrary.wiley.com/doi/10.1111/all.14842?af=R.

Artificial Intelligence

Universal Robots and MiR open new robotics hub in Denmark

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Global robotics leaders Universal Robots (UR) and Mobile Industrial Robots (MiR), both Teradyne Robotics companies, will share headquarters to increase synergies and accelerate innovation within advanced robotics. 
ODENSE, Denmark, May 14, 2024 /PRNewswire/ — Universal Robots, the Danish collaborative robot (cobot) company, and MiR, the Danish manufacturer of AMRs (autonomous mobile robots), today celebrated the Grand Opening of their new 20,000 sqm headquarters in Odense, Denmark.

Partners from UR and MiR’s global ecosystems attended the event, including NVIDIA and Siemens, with whom Teradyne Robotics and its companies have recently announced several collaborations.
“The launch of this new headquarters marks a significant milestone for Teradyne Robotics as we bring together two leading companies in robotics innovation,” says Ujjwal Kumar, Group President of Teradyne Robotics. “We will now have the optimal environment to evolve our technological capabilities, which are already in high demand.”
On the new robotics hub, Jean-Pierre Hathout, President of MiR, said:”Our new headquarters is designed to foster innovation, providing the perfect setting for our teams to develop leading-edge solutions that will revolutionize automation. MiR is committed to being a one-stop-shop for material handling, continuously advancing our technology to meet the evolving needs of our large, global customers. Our recently launched AI-powered MiR1200 Pallet Jack exemplifies this dedication. I’m thrilled to witness the transformative impact of our endeavors and to showcase MiR’s and UR’s offerings to our customers and partners at this state-of-the-art facility.”
Kim Povlsen, President of Universal Robots, added:”Since our foundation, UR has become a platform of choice for thousands of customers and hundreds of ecosystem partners. This beautiful building reflects our strong design philosophy and provides the perfect location for us to continue our mission to deliver automation for anyone, anywhere.”
Transformative power of advanced automationThe opening included a panel discussion featuring Deepu Talla, Vice President of Robotics and Edge Computing of NVIDIA, Rainer Brehm, CEO of Siemens Factory Automation, and Ujjwal Kumar, Group President of Teradyne Robotics. The panelists discussed the use of physical AI across industries, underscoring the transformative power of advanced automation for businesses and workplaces.
Photos from the Grand Opening and a recording of the panel discussion can be viewed on UR and MiR social media channels and will soon be available here.
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About URAbout MiRAbout Teradyne Robotics
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Mullen Coughlin LLC Adds DFIR Professional, Chris Ballod, to Incident Response Team

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DEVON, Pa., May 14, 2024 /PRNewswire/ — Mullen Coughlin LLC, a leading international data privacy and security law firm, proudly announces the addition of Chris Ballod  to the Incident Response team as Senior Partner.

With a legal and professional career spanning over two decades where he held prominent positions within the cyber insurance ecosystem, including most recently as Associate Managing Director for a well-known cybersecurity risk management and digital forensic incident response (DFIR) firm, Chris possesses a deep understanding of the complicated and nuanced data privacy legal landscape and real-life experience in leading forensic investigations into hundreds of various types of data privacy incidents.
“It is my great honor to join the team that made the incident response community what it is today. The attorneys and staff at Mullen Coughlin are some of the best and most experienced in the field, and I am excited for us to face the future of this industry together,” says Chris about joining the Firm. 
Chris’s addition reinforces Mullen Coughlin’s commitment to delivering effective and efficient legal services tailored to each organization’s unique needs – prior, during, and after a data privacy and security incident. With a proven record of success for organizations around the globe, Chris’s knowledge and experience further strengthens Mullen Coughlin’s ability to provide unmatched cybersecurity and data privacy legal counsel to organizations of all sizes and across all industry sectors.
“The addition of our friend, and now colleague, is another chapter in the Firm’s dedication to one theme – One Firm, One Focus: Cyber,” says Mullen Coughlin CEO John F. Mullen . “I’ve worked with Chris for many years, both at previous law firms and as a business partner, and know that he will make an immediate impact here and for our clients and cyber insurance partners.”
Mullen Coughlin Managing Member, Jennifer A. Coughlin , adds, “Chris is recognized by all in the market as having unmatched legal and forensic investigatory experience, and we are excited for him to utilize this experience to further solidify the Firm’s established reputation as the go-to law firm for data privacy and incident response legal counsel, consistently delivering on the needs of the cyber insurance industry.”
Mullen Coughlin has managed over 25,000 data privacy and security incidents on behalf of organizations of all sizes, across all industry sectors and from all geographic locations. Mullen Coughlin has over 120 experienced attorneys solely dedicated to providing bespoke counsel relating to pre-incident Advisory Compliance  services and solutions; data privacy and security incident response ; regulatory investigation ; and security and privacy litigation  defense. For more information, please visit www.mullen.law .

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QorusDocs’ New AI-Powered Solution, QPilot, Transforms RFP and Proposal Development

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Specialized, private and secure AI features return immediate ROI to professional services firms
BELLEVUE, Wash., May 14, 2024 /PRNewswire/ — QorusDocs, an AI-powered proposal management software provider, today announced QorusDocs’ QPilot, a new secure and private AI service that exponentially simplifies the task of crafting pitches, proposals and RFP responses for professional services firms.

Core Features Ensure Security, Privacy and Immediate ROI
QorusDocs’ QPilot AI service, built on the Microsoft Azure OpenAI Service, offers unparalleled security and privacy for firm’s private content libraries, past RFPs, proposals and internal content.
QPilot gives users access to pre-built and customizable prompts that make it indispensable for professional services teams, who frequently work with biographies, credentials and project records in volume, and need to craft compelling written and visual presentations.
By allowing secure, targeted access to a firm’s sensitive documents and content, QPilot produces advantages for proposal creators not found in other generative AI software. This allows business development teams to focus on high-value client engagement, instead of mundane tasks.
QorusDocs AI Assistant, QPilot, brings the following benefits to users:
Accelerates research, personalization, and creation of tailored content Streamlines workflows directed towards high-value, winnable bids Integrates seamlessly with Microsoft 365 apps for ease of use “We developed QorusDocs’ QPilot as part of our continued focus on expanding our AI footprint to help service-based businesses revolutionize their proposal process,” said Ray Meiring, CEO and co-founder of QorusDocs. “During our testing phase, we verified common use cases for professional services teams and gathered feedback to ensure the first version of QorusDocs’ AI Assistant, QPilot, returns immediate time to value to our customers.”
The Verdict is in: Customers Love QorusDocs’ QPilot 
“QorusDocs’ AI platform has brought significant efficiency gains to TRC’s proposal process”, explained Dr. Stephen R. Galati, Vice President, Strategic Proposals, TRC Companies, Inc. “Before QorusDocs’ QPilot, we would spend time searching for information and refining it into proposals. Now, with QorusDocs’ QPilot, we’ve experienced notable productivity gains, specifically planning, resource, writing, collaboration and time efficiencies, allowing our team to focus on the technical content rather than stylistic elements. QorusDocs’ seamless integration with Microsoft 365 apps provides fast access to information and gives us a strong level of confidence in data security.” 
Customer and Analyst Acclaim 
Known for its compelling platform, QorusDocs has received top honors by SoftwareReviews in its research analysis. In April 2024, QorusDocs was ranked #1 in product performance and Champion in Emotional Sentiment in the Proposal Management category.
In line with its existing platform, QorusDocs’ QPilot has already earned high praise from customers and analysts who have used the preview version, with 100% of users reporting productivity increases. 
“Generative AI is creating exponential opportunities across the professional services industry, shared Robert Garmaise, Vice President of Artificial Intelligence Research at Info-Tech Research Group. QorusDocs is both a leader and chief catalyst in this transformation, as they streamline critical sales deliverables such as pitches, proposals and RFP responses. QorusDocs is a no-brainer for any professional services partner looking to maximize their reach while minimizing non-billable time.”
QorusDocs’ AI Assistant, QPilot will be available on June 5, 2024.
To see how QorusDocs’ QPilot can transform your proposal processes, visit QorusDocs AI Assistant | QPilot.
ABOUT QORUSDOCS QorusDocs, based in Bellevue, Wash., is a leader in AI-powered proposal management and RFP response software that automates the creation of personalized pitches, presentations, proposals, and RFP responses. QorusDocs empowers business development, sales, marketing, and proposal teams to collaborate seamlessly, optimizing billable hours and increasing client wins. The company supports enterprise revenue teams from companies like WSP, CDW, DLA Piper, Baker McKenzie, Insight and more. 
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