Connect with us
MARE BALTICUM Gaming & TECH Summit 2024

Uncategorized

DP Technology Announces Nomination of Development Candidate, a Potential Best-in-Class Kv1.3 Inhibitor for Immunological Diseases Including IBD and AD

Published

on

dp-technology-announces-nomination-of-development-candidate,-a-potential-best-in-class-kv1.3-inhibitor-for-immunological-diseases-including-ibd-and-ad

 
DP Technology, an “AI for Science” new paradigm-driven company, today announced the nomination of DPT0218, a novel small molecule targeting Kv1.3, as a preclinical candidate compound for the treatment of various autoimmune diseases, including Inflammatory Bowel Disease (IBD) and Atopic Dermatitis (AD).
The voltage-gated potassium channel Kv1.3 is known to be crucial for maintaining the membrane potential required for the induction of inflammatory responses[1] because Kv1.3 inhibition reduces calcineurin mediated immune cell activation and proliferation[2]. Inhibition of Kv1.3 therefore offers a potential opportunity to specifically impair inflammatory immune cell activity and proliferation, including in antigen-activated T cells. Previously, Eli Lilly and Company (Lilly) made an initial payment of $60 million to D. E. Shaw Research (DESRES), with potential development and commercial milestone payments of up to $475 million for DES-7114, a lead compound of the Kv1.3-targeted therapeutics program.
Recently, the activity of T cells has become a compelling intervention point in IBD[3]. Long-lived memory T-cell populations, particularly tissue resident subsets, may contribute to the chronicity of IBD and represent a potential target for therapy[4]. Kv1.3 expression was elevated in PBMCs from UC patients and correlated with the prevalence of Th1 and Th2 T cells. Kv1.3 expression was also detected on T cells from biopsies of UC patients[5].
It is estimated that there are at least 8 million IBD patients worldwide, of which more than 5 million in Europe and the U.S. The global market for autoimmune drugs is projected to reach $140 billion by 2028, with IBD medications accounting for $28 billion, representing 20% of the market share.
DPT0218 is a potential ‘best-in-class’ highly selective Kv1.3 inhibitor with a novel scaffold. It has shown positive results in preclinical animal models of various autoimmune diseases such as IBD and AD. The compound exhibits sub-nanomolar potency and has achieved over 2000-fold selectivity for the Kv1.3 channel over a range of other ion channels, including Na+, K+, and Ca2+. It also showed unique DMPK profiles, high colon/ileum concentrations with low systemic exposure in multiple species, demonstrating an excellent safety profile in preclinical studies.
“Although antibodies play a pivotal role in the treatment of moderate to severe IBD, their applications are limited by constrained therapeutic efficacy, immunogenicity, parenteral route of drug delivery, poor tolerability, and high cost.” said Xiaomin Zhang, Head of Drug Discovery at DP Technology. “As a small molecule, DPT0218 has shown potent inhibition of T cell activation, proliferation, and cytokine secretion in both in vivo and in vitro studies, demonstrating its potential as an effective treatment for IBD. We’ll actively advance DPT0218 to clinical research and explore its application to other autoimmune diseases.”
“DP Technology is the pioneer of AI for Science paradigm, dedicated to integrating ‘AI + Simulation + Experiments’ to address unmet clinical needs.” said Weijie Sun, Founder and CEO of DP Technology. “The dynamics of ion channels are extremely complicated, and our RiDYMO® platform is unequivocally well-suited for the drug development of these highly challenging systems. The successful discovery of DPT0218 is an important step towards achieving the AI for Science vision. We look forward to collaborations with seasoned partners to advance this program to the next milestone.”
The RiDYMO® drug design platform integrates various AI and physical algorithms, dedicated to the development of drugs for “undruggable” targets and “best-in-class” molecules. As one of its core algorithms, Reinforced Dynamics (RiD) has a significant advantage in the sampling efficiency of molecular dynamics simulation. By fully leveraging the high-dimensional representation capabilities of neural networks, RiD can efficiently capture dynamic conformational changes in complicated biomolecular systems.
The RiDYMO® platform is dedicated to studying the dynamics of biological systems and revealing cryptic binding sites, encompassing a range of challenging systems including protein-protein interactions (PPIs), intrinsically disordered proteins (IDPs), membrane proteins, RNA, and others. It has also been validated on “undruggable” targets including c-Myc and GPX4.

The post DP Technology Announces Nomination of Development Candidate, a Potential Best-in-Class Kv1.3 Inhibitor for Immunological Diseases Including IBD and AD appeared first on HIPTHER Alerts.

Continue Reading

Uncategorized

Sainsbury’s aims to be an ‘AI-enabled grocer’ with Microsoft AI technology

Published

on

sainsbury’s-aims-to-be-an-‘ai-enabled-grocer’-with-microsoft-ai-technology

 
Sainsbury’s, a prominent UK supermarket chain, is set to leverage Microsoft’s artificial intelligence and machine learning tools to elevate its store operations and provide customers with a more engaging and convenient shopping experience.
As part of its strategic initiative, the ‘Next Level Sainsbury’s strategy’, the supermarket will integrate generative AI, powered by Microsoft Azure, to enhance its online shopping platform and optimize customers’ search experience. By harnessing AI capabilities, Sainsbury’s aims to offer a more interactive and personalized online shopping journey for its millions of customers across the UK.
In addition to enhancing the online shopping experience, Sainsbury’s plans to equip its store colleagues with real-time data and insights to streamline in-store processes such as shelf replenishment. Leveraging multiple data inputs, including shelf-edge cameras, AI technology will guide colleagues on prioritizing restocking activities, thereby improving efficiency and productivity.
Over the next five years, Sainsbury’s will deploy Microsoft Azure to implement these initiatives, integrating data assets with Microsoft 365 collaboration tools to drive innovation and operational excellence.
Clodagh Moriarty, Chief Retail and Technology Officer at Sainsbury’s, expressed confidence in the collaboration with Microsoft, emphasizing its role in accelerating the supermarket’s ambition to become the UK’s leading AI-enabled grocer. Moriarty highlighted the strategic investment in transformative capabilities, aimed at enhancing efficiency, productivity, and customer service while delivering value to shareholders.
Clare Barclay, CEO of Microsoft UK, commended Sainsbury’s visionary approach, noting its commitment to placing AI at the forefront of its business strategy. Barclay expressed enthusiasm for the collaboration, emphasizing its potential to revolutionize the retail experience for both customers and store colleagues.
The partnership between Sainsbury’s and Microsoft signifies a significant step towards ushering in the next generation of retail, powered by innovative AI-driven solutions.
Source: technologyrecord.com
The post Sainsbury’s aims to be an ‘AI-enabled grocer’ with Microsoft AI technology appeared first on HIPTHER Alerts.

Continue Reading

Uncategorized

Researchers build AI-driven sarcasm detector

Published

on

researchers-build-ai-driven-sarcasm-detector

 

Artificial intelligence has made remarkable strides, from passing bar exams to reading bedtime stories with emotion. Yet, despite these feats, it still falls short of matching the intricate nuances of human communication—particularly, the art of sarcasm.
However, researchers in the Netherlands are determined to change that narrative. They have developed an AI-driven sarcasm detector that can discern when sarcasm is being used, a feat previously thought to be exclusive to human cognition.
Matt Coler, from the University of Groningen’s speech technology lab, expresses excitement about the project’s progress. He emphasizes the importance of understanding sarcasm, a pervasive aspect of human discourse, to facilitate seamless communication between humans and machines.
Recognizing sarcasm poses challenges due to its subtlety, especially in text-based interactions where cues like tone and facial expressions are absent. To overcome this, researchers trained their AI using a combination of text, audio, and emotional content from popular sitcoms like Friends and The Big Bang Theory.
The AI, trained on annotated data from these shows, demonstrated an impressive ability to detect sarcasm in unlabelled exchanges from the sitcoms, achieving an accuracy rate of nearly 75%. Further enhancements are underway, including incorporating visual cues like eyebrow movements and smirks, to improve accuracy even more.
Beyond enhancing interactions with AI assistants, this technology holds potential for detecting negative language and identifying instances of abuse or hate speech. However, as AI becomes more adept at understanding sarcasm, questions arise about its potential to wield sarcasm itself.
Coler muses about the implications of machines responding with sarcasm, raising concerns about clarity in communication. Nonetheless, advancements in AI-driven sarcasm detection offer promising prospects for improving human-machine interactions and bridging the gap between artificial and human intelligence.
Source: theguardian.com

The post Researchers build AI-driven sarcasm detector appeared first on HIPTHER Alerts.

Continue Reading

Uncategorized

AI, bias and experiments: how Women in News is tackling tech’s inbuilt stereotypes

Published

on

ai,-bias-and-experiments:-how-women-in-news-is-tackling-tech’s-inbuilt-stereotypes

 

Issues surrounding bias in AI are deeply rooted in the accuracy, trustworthiness, and quality of data, which, if overlooked, can significantly skew outcomes. Lyndsey Jones, an AI author and transformation coach, delves into these concerns, offering valuable insights for newsrooms on monitoring and reviewing data.
Madhumita Murgia, an AI journalist and the first artificial intelligence editor of the Financial Times, sheds light on how women, migrants, precarious workers, and minority groups are disproportionately affected by the technical limitations of Generative AI. Murgia emphasizes the lack of representation of these groups in the development process of AI technologies, highlighting the need for inclusive participation.
WAN-IFRA Women In News workshops on the Age of AI in the newsroom have brought bias effects to the forefront. Through the Digital ABCs training program, media professionals are equipped with skills to navigate the digital landscape and drive organizational change.
A newly launched module focuses on AI, with over 100 participants in eastern Europe taking part, now extended to journalists in parts of Africa, the Middle East, and Southeast Asia. Instances of bias surfaced during the training, such as generating offensive avatars and misinterpretation of accents in AI tools.
Google CEO Sundar Pichai’s acknowledgment of biased AI tools reflects ongoing concerns in the industry. Timnet Gebru’s dismissal from Google for highlighting biases further underscores the need for vigilance in addressing these issues.
Diverse teams in WIN’s Age of AI program are experimenting with various tools like fact-checking and enhancing staff skill sets in AI usage. Projects under consideration for further EU funding include a video lab for content amplification and an AI avatar for journalist safety.
Media companies must ensure diverse staff collaboration when testing AI tools. Quotas for women in AI research and cross-border partnerships may be necessary for smaller media groups to compete effectively.
Journalists can take steps to improve content quality by examining storytelling practices and ensuring diversity in sources and representation. Consistency of data collection across departments and assessing biases in data sets are crucial for ethical AI usage in journalism. Ultimately, AI tools should be used to enhance journalism’s quality and integrity, rather than generating clickbait or misinformation.
Source: wan-ifra.org

The post AI, bias and experiments: how Women in News is tackling tech’s inbuilt stereotypes appeared first on HIPTHER Alerts.

Continue Reading

Trending