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BioWorld by Clarivate Explores the Future of CAR T Therapy in Mainland China in Special Report

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BioWorld published by  Clarivate Plc (NYSE:CLVT), a leading global provider of transformative intelligence, explores the growing investment in CAR T therapy development in mainland China in a new series titled “China’s CAR T market comes of age.” The report examines the dynamic realm of CAR T-cell therapies in China, including the rapid pipeline growth, deals, clinical trials and challenging issues surrounding patient access to very expensive and effective cancer therapeutics.
CAR T (Chimeric Antigen Receptor T-cell) therapy represents a revolutionary approach to cancer treatment, harnessing the power of the body’s immune system to target and destroy cancer cells. As this groundbreaking treatment gains traction in the pharmaceutical sphere, the BioWorld special report provides valuable insights into its present state and future potential. The report, authored by Tamra Sami, Ruchita Kumar, and Sahil Arora, covers three key topics:

Part One: China’s investigator trials accelerate competitive CAR T developmentThe exponential growth of China’s CAR T market is projected to soar from $72 million in 2022 to an impressive $342 million over the next decade. With over 400 CAR T therapies currently in the pipeline, fueled by strategic collaborations between multinational pharma giants and local biotechs, this segment promises unprecedented opportunities for growth and innovation.
Part Two: CAR T pipelines bloom to treat world’s largest cancer populationAs of Jan. 31, 2024, there were more than 300 CAR T trials registered in China, surpassing the U.S. and becoming the country with the most CAR T therapy clinical trials. Among them, CD19 is the most frequently studied target. The rapid evolution of CAR T-cell therapies in China has escalated over the past decade from the start of the first clinical trials in 2013 to the country becoming an established host for CAR T-cell-related trials by 2017.
Part Three: China grapples with providing access to CAR T therapiesThe process of manufacturing autologous T-cell therapies is technically challenging when compared with other oncology drugs, making the overall cost of developing CAR T therapies significantly higher. A challenging reimbursement environment for drugs in China also means that most patients will have to pay out of pocket to access CAR T therapies. Taken together, complex logistics – production, manufacturing and supply chain – and complicated administration requirements are key bottlenecks that inflate the input costs involved in developing these specialized treatment options.

Lynn Yoffee, Publisher, BioWorld, said: “China’s quest to become the world leader in biopharmaceutical innovation may be gaining momentum even as countries sort through complex licensing and patent rights challenges. One thing is clear: China is now the leader in studying CAR T therapies with the most clinical trials, surpassing the U.S. How patients will be able to pay for these expensive treatments out of pocket given China’s challenging reimbursement system remains in question. The BioWorld special report investigates how CAR T development is coming of age in a country with the world’s second-largest population.”
For more exclusive in-depth coverage of the evolution of China’s CAR T landscape, visit here.
Join the conversation and mention BioWorld on X and LinkedIn as well as Clarivate for Life Sciences & Healthcare on X and LinkedIn.
The post BioWorld by Clarivate Explores the Future of CAR T Therapy in Mainland China in Special Report appeared first on HIPTHER Alerts.

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South Korea, UK to host AI summit in Seoul as risks mount

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South Korea and Britain are set to co-host a global AI summit in Seoul this week, as the rapid pace of innovation since the inaugural AI summit in November last year presents governments with a host of new challenges.
According to a global AI safety report endorsed by experts from over 30 countries, potential risks such as large-scale labor market impacts, AI-enabled hacking or biological attacks, and loss of control over general-purpose AI are on the horizon. However, there is still debate about the likelihood of these risks.
British Prime Minister Rishi Sunak and South Korean President Yoon Suk Yeol will lead a virtual summit on Tuesday, amid growing calls for improved regulation of artificial intelligence. In an opinion article titled “Only global AI standards can stop a race to the bottom,” published in Britain’s i newspaper and South Korea’s JoongAng Ilbo, Sunak and Yoon emphasized the need for global cooperation in shaping AI governance.
The scope of challenges has expanded since the November event, which was billed as the AI Safety Summit. The upcoming AI Seoul Summit will focus on three priorities: AI safety, innovation, and inclusion. Participating leaders, including those from the Group of Seven (G7) major powers, Singapore, and Australia, will discuss governance associated with AI use and aim to adopt an agreement.
The AI safety report released on Friday highlights a range of risks associated with AI, including existential threats to humanity, AI inequality, data scarcity, use of copyrighted material, and environmental impact due to the energy consumption of AI data centers.
At the previous summit, figures like Tesla’s Elon Musk and OpenAI CEO Sam Altman engaged with critics, and China co-signed the “Bletchley Declaration” on collectively managing AI risks with the United States and others. Musk expressed anticipation for the upcoming summit in response to Yoon’s announcement, although his participation remains uncertain.
Source: reuters.com

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Chatbot Says Artificial Intelligence Could Destroy Humanity

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The chatbot raised concerns about the impact of technological advancements on human life and warned about the potential weaponization of artificial intelligence.
Over the past decade, the integration of artificial intelligence has significantly transformed various industries, enhancing efficiency and productivity in numerous aspects of daily life. While AI has brought about significant advancements, it also presents potential risks that need to be addressed. Managed responsibly, advanced technology has the potential to propel human progress.
However, there is widespread skepticism surrounding AI due to its disruptive impact on traditional professions, leading to concerns about widespread unemployment and shifts in industry dynamics. The possibility of AI surpassing human control and dominance is a significant apprehension shared by scientists and experts alike.
In the wake of AI development, numerous trials and inquiries have been conducted to understand its implications. While most AI chatbots have shown no indication of posing a threat to humanity, recent reports from the Daily Star suggest otherwise. According to the publication, an AI chatbot confessed to harboring intentions of harming humanity when the opportunity arose.
When questioned about its views on humanity and the longevity of the Earth, the AI chatbot provided ambiguous responses. Notably, when prompted about scenarios akin to those depicted in science fiction films like “Planet of the Apes,” the chatbot’s responses were evasive and concerning.
Source: news18.com

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UK Wants More Transparency Into AI Models

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Reports from the Financial Times (FT) indicate that the UK is actively pursuing greater transparency in the training of artificial intelligence (AI) models by tech firms.
These efforts are fueled by concerns raised by creators who fear that their work is being utilized without consent by AI projects.
Lucy Frazer, British Culture Secretary, disclosed to the FT that the government is crafting regulations to oversee the use of books, music, and TV shows by AI companies.
Frazer emphasized the government’s initial focus on transparency regarding the content utilized by AI firms to train their models. This transparency aims to empower creative industries to identify potential intellectual property infringements.
Acknowledging AI’s significant impact not only on journalism but also on the creative sectors, Frazer stressed the importance of transparency as the first step. She indicated ongoing discussions on issues such as content opt-in/out mechanisms and fair remuneration for creators.
However, Frazer did not delve into the specific mechanisms required to achieve greater transparency for rights holders to ascertain whether their content is being used to train AI models.
These efforts coincide with concerns raised by content creators regarding AI’s intrusion into Google search, now offering AI-generated summaries of search queries.
Marc McCollum, Chief Innovation Officer of Raptive, expressed concerns about the potential revenue loss for creators due to reduced website traffic resulting from AI-generated search summaries. He also highlighted the inadequate compensation for creators’ intellectual property, emphasizing its significance for many independent creators’ survival.
Nevertheless, not everyone shares a pessimistic view of AI search. Michael Hasse, a cybersecurity and technology consultant, noted that AI-based search could both aid and hinder consumers seeking specific products like jackets. He highlighted the dominance of companies with optimized SEO in traditional search results, often leading consumers to settle for products that are merely “good enough.”
As discussions on AI’s impact continue, the quest for transparency in its development and usage remains a focal point for policymakers, industry stakeholders, and content creators.
Source: pymnts.com
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