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myCare Clinical Studies Show Cellworks Singula™ Achieves Superior Therapy Response Predictions for Brain Cancer Patients

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SOUTH SAN FRANCISCO, Calif., May 29, 2020 (GLOBE NEWSWIRE) — Cellworks Group, Inc., a world leader in Personalized Medicine in the key therapeutic areas of Oncology and Immunology, today announced results from the myCare-009-03 and myCare-009-04 clinical studies, which demonstrate that Cellworks Singula™ is a superior predictor of progression-free survival (PFS) and overall survival (OS) in Glioblastoma (GBM) and Low-Grade Glioma (LGG) patients, compared to physician prescribed treatments.
The results from myCare-009-03 and myCare-009-04 clinical studies will be featured as poster presentations with comments from Dr. Manmeet Ahluwalia, MD, Cleveland Clinic, Brain Tumor and Neuro-Oncology Center as part of the ASCO20 Virtual Scientific Program May 29 – May 31, 2020 and available as online abstracts 2519 and 2569, respectively. ASCO20 registrants can also listen to a discussant commentary in the Central Nervous System Tumors Poster Session Track titled, Identifying and Validating Novel Biomarkers in Glioma, with Dr. Karla Ballman, Chief of Biostatistics and Epidemiology, Weill Cornell Medical College, in which the myCare-009-03 clinical study will be discussed.“Biosimulating therapy responses using patient-specific multi-omics data is an important advancement for GBM and LGG patients,” said Dr. Patrick Wen, MD, Director, Center For Neuro-Oncology, Dana-Farber Cancer Institute; Professor, Neurology, Harvard Medical School; and co-Primary Investigator for myCare-009-03 and myCare-009-04 clinical studies. “These studies underscore the benefits of moving beyond a sole reliance on NGS reports for prescribing cancer treatments. The predictions in these studies delivered precise therapy response information at an individual patient level – fulfilling on the promise of Personalized Medicine.”Outcomes for GBM and subsets of LGG patients have remained poor despite using cytogenetic and molecular-risk stratification along with Precision Medicine. Therapy selections for GBM and LGG patients are typically based on next-generation sequencing (NGS) reports and information that only considers a single aberration while ignoring many molecular pathways as well as other patient-specific multi-omics data, which can be used to inform a more effective therapy selection.“In order to improve outcomes for GBM and LGG patients, we need to understand the effects of multiple aberrations at an individual patient level, which requires analysis beyond that of current NGS reports,” said Dr. Ahluwalia, MD, Cleveland Clinic, Brain Tumor and Neuro-Oncology Center and Primary Investigator for myCare-009-03 and myCare-009-04 clinical studies. “These Cellworks myCare studies illustrate that by using multi-omic data and biosimulating GBM and LGG patient therapy responses with the Cellworks Biosimulation Model (CBM), we gain predictive information above and beyond physician prescribed treatments that currently rely only on NGS reports.”Cellworks Singula™ therapy response predictions are generated through extensive biosimulation of a personalized patient disease model based on the patient’s multi-omics data. Utilizing an in-silico model of thousands of genes, Cellworks Singula™ analyzes the downstream pathway impact of genomic, proteomic, transcriptomic and epigenomic aberration information on a patient’s disease. These downstream effects generate phenotypic impact, which are calculated against specific drugs or drug combinations to determine treatment efficacy. The Cellworks biosimulation platform can predict an individual patient’s therapy response prior to receiving the treatment, thereby reducing the patient risks and payer costs of unsuccessful treatments and ultimately saving lives.myCare-009-03 Clinical StudyIn this prospective retrospective study, an independent randomly selected cohort of 109 GBM patients aged 17 to 83 years and treated with physician prescribed therapies were selected. Patient multi-omics data from The Cancer Genome Atlas (TCGA) was used along with information from PubMed to generate protein interaction network activated and inactivated disease pathways. The physician prescribed therapy for each patient was biosimulated to calculate the quantitative drug effect, using a composite GBM disease inhibition score based on specific phenotypes, while blinded to clinical response.Study results show Cellworks Singula™ delivered predictions with 91.2% positive predictive value (Exact 95% CI: 80.7%, 97.1%) and 90.4% negative predictive value (95% CI: 79.0%, 96.8%) for clinical response as defined as either a complete response or partial response. In the study, Cellworks Singula™ performed with 91.2% sensitivity (95% CI: 80.7%, 97.1%) and 90.4% specificity (95% CI: 79.0%, 96.8%). The results also indicate that Cellworks Singula™ is a superior predictor of OS (HR = 1.852, p = 0.0070) and PFS (HR = 4.0333, p = < 0.0001) compared to physician prescribed treatments using NGS reports alone.myCare-009-04 Clinical StudyAn independent cohort of 137 LGG patients aged 14 to 73 years and treated with physician prescribed treatments were randomly selected for this prospective retrospective study. Patient multi-omics data from The Cancer Genome Atlas (TCGA) was used along with information from PubMed to generate protein interaction network activated and inactivated disease pathways. The physician prescribed treatment was biosimulated for each patient to calculate the quantitative drug effect, using a composite LGG disease inhibition score based on specific phenotypes, while blinded to clinical response.Study results show Cellworks Singula™ delivered 89.3% positive predictive value (Exact 95% CI: 81.7%, 94.6%) and 82.4% negative predictive value (95% CI: 65.5%, 92.3%) for clinical response as defined as either a complete or partial response. In the study, Cellworks Singula™ performed with 93.9% sensitivity (95% CI: 87.1%, 97.7%) and 71.8% specificity (55.1%, 85.0%). Results from the study demonstrate that Cellworks Singula™ is a high predictor of OS (HR = 2.970, p = 0.0013), a significant independent predictor of PFS (HR = 3.707, p = < 0.0001) in LGG patients and provides predictive information above and beyond physician prescribed treatment. Cellworks Singula™ also correctly identified non-responders to physician prescribed treatments and provided alternative therapy selections for all 34 disease progressors.“These studies demonstrate significant progress in the journey to increase survival rates for brain cancer patients,” said Yatin Mundkur, CEO of Cellworks. “Cellworks Singula™ enables oncologists to deeply understand which therapies will be efficacious for individual GBM and LGG patients and to avoid prescribing ineffective therapies that waste precious time.”About Cellworks GroupCellworks Group, Inc. is a world leader in Personalized Medicine in the key therapeutic areas of Oncology and Immunology. Using innovative multi-omics modeling, computational biosimulation and Artificial Intelligence heuristics, Cellworks predicts the most efficacious therapies for patients. The Cellworks unique biosimulation platform is a unified representation of biological knowledge curated from heterogeneous datasets and applied to finding cures. Backed by Sequoia Capital and Artiman Ventures, Cellworks has the world’s strongest trans-disciplinary team of molecular biologists, cellular pathway modelers and software technologists working toward a common goal – attacking serious diseases to improve the lives of patients. The company is based in South San Francisco, California and has a research and development facility in Bangalore, India. For more information, visit www.cellworks.life and follow us on Twitter @cellworkslife.All trademarks and registered trademarks in this document are the properties of their respective owners.Media Contacts:Barbara Reichert
Reichert Communications, LLC
Barbara@reichertcom.com
415-225-2991
Michele Macpherson, Chief Business Officer
Cellworks Group, Inc.
michele.macpherson@cellworksgroup.com
A photo accompanying this announcement is available at: https://www.globenewswire.com/NewsRoom/AttachmentNg/372136af-4901-4fc0-82e0-618ede722f19

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GENFIT: Enhances Board of Directors with Two Strategic Appointments

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Lille (France), Cambridge (Massachusetts, United States), July 7, 2020 – GENFIT (Nasdaq and Euronext: GNFT), a late-stage biopharmaceutical company dedicated to improving the lives of patients with metabolic and liver diseases, today announced, following its annual Shareholders Meeting,  the appointment of Ms. Katherine Kalin and Mr. Eric Baclet to the company’s Board of Directors. Together, they bring more than 50 years of combined pharmaceutical experience and deep subject matter expertise that will aid in the next phase of Genfit’s growth.Pascal Prigent, CEO of GENFIT, noted: “We are delighted to announce the appointments of Katherine and Eric to the board. Both bring a wealth of highly relevant life science industry experience. Ms. Kalin has extensive strategic and financial management experience in both pharmaceutical and diagnostic solutions, with a deep understanding of the U.S. market. Mr. Baclet has a broad experience covering therapeutic drug development, as well as commercial management in several markets, including China. Both will bring strong knowledge bases and strategic insights as the company works to determine the next corporate steps that will shape its transformation.”Ms. Kalin’s healthcare industry expertise spans diagnostics, medical devices, and pharmaceuticals. Ms. Kalin is currently a director on the boards of Clinical Genomics, a molecular diagnostic firm, Brown Advisory, a strategic advisory and investment firm, and Primari Analytics, a startup in artificial intelligence.  From 2012-17, Ms. Kalin led corporate strategy at Celgene, a global biopharmaceutical company, for 5 1/2 years. Prior to that, Ms. Kalin held executive leadership roles in marketing, sales, strategy and new business development at Johnson & Johnson (J&J) from 2002 to 2011. Prior to J&J, Ms. Kalin served as a Partner at McKinsey and Company, a global management consulting firm, where she negotiated and led consulting assignments, as a strategic advisor to pharmaceutical, medical device and other healthcare companies.Mr. Eric Baclet has over 30 years of experience with Eli Lilly in international drug development, management, and commercialization, all expertise he gained as President and General Manager of Lilly Italia, General Manager of Lilly China, VP of Global Marketing, and Executive Directorship of International Marketing, to name a few. Throughout his tenure at Eli Lilly, Mr. Baclet spearheaded international drug launches across multiple geographies, and led multi-disciplinary teams involved in biopharmaceutical value-chain management in more than seven countries.Jean-François Mouney, Chairman of the Board, added: “The Board is thrilled to welcome Katherine and Eric. We look forward to working with Pascal and the GENFIT team to help the company build value and succeed in its development programs in therapeutic areas with high unmet medical need.” ABOUT GENFITGENFIT is a late-stage biopharmaceutical company dedicated to the discovery and development of innovative therapeutic and diagnostic solutions in metabolic and liver related diseases where there are considerable unmet medical needs, corresponding to a lack of approved treatments. GENFIT is a pioneer in the field of nuclear receptor-based drug discovery, with a rich history and strong scientific heritage spanning more than two decades. Its drug candidate, elafibranor, is currently being evaluated in a pivotal Phase 3 clinical trial (“RESOLVE-IT”) as a potential treatment for NASH and GENFIT plans to initiate a Phase 3 clinical trial of elafibranor in patients with PBC. As part of GENFIT’s comprehensive approach to clinical management of patients with NASH, the Company is also developing a new, non-invasive blood-based diagnostic technology, NIS4™, which, if approved, could enable easier identification of patients with at-risk NASH. With facilities in Lille and Paris, France, and Cambridge, MA, USA, the Company has approximately 200 employees. GENFIT is a publicly traded company listed on the Nasdaq Global Select Market and on compartment B of Euronext’s regulated market in Paris (Nasdaq and Euronext: GNFT). www.genfit.com
FORWARD LOOKING STATEMENTSThis press release contains certain forward-looking statements, including those within the meaning of the Private Securities Litigation Reform Act of 1995, with respect to GENFIT, including statements about the Company’s next development and transformation steps, its potential to create value, and new Directors’ contribution to value creation. The use of certain words, including “believe,” “potential,” “expect” and “will” and similar expressions, is intended to identify forward-looking statements.  Although the Company believes its expectations are based on the current expectations and reasonable assumptions of the Company’s management, these forward-looking statements are subject to numerous known and unknown risks and uncertainties, which could cause actual results to differ materially from those expressed in, or implied or projected by, the forward-looking statements. These risks and uncertainties include, among other things, the uncertainties inherent in research and development, including related to safety, biomarkers, progression of, and results from, its ongoing and planned clinical trials, review and approvals by regulatory authorities of its drug and diagnostic candidates and the Company’s continued ability to raise capital to fund its development, as well as those risks and uncertainties discussed or identified in the Company’s public filings with the French Autorité des marchés financiers (“AMF”), including those listed in Section 2.1 “Main Risks and Uncertainties” of the Company’s 2019 Universal Registration Document filed with the AMF on May 27, 2020 under n° D.20-0503, which is available on GENFIT’s website (www.genfit.com) and on the website of the AMF (www.amf-france.org) and public filings and reports filed with the U.S. Securities and Exchange Commission (“SEC”), including the Company’s 20-F dated May 27, 2020. In addition, even if the Company’s results, performance, financial condition and liquidity, and the development of the industry in which it operates are consistent with such forward-looking statements, they may not be predictive of results or developments in future periods.  These forward-looking statements speak only as of the date of publication of this document. Other than as required by applicable law, the Company does not undertake any obligation to update or revise any forward-looking information or statements, whether as a result of new information, future events or otherwise.CONTACTGENFIT | InvestorsNaomi EICHENBAUM – Investor Relations | Tel: +1 (617) 714 5252 | investors@genfit.com
PRESS RELATIONS | MediaHélène LAVIN – Press relations | Tel: +333 2016 4000 | helene.lavin@genfit.com
AttachmentGENFIT: Enhances Board of Directors with Two Strategic Appointments

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Second Front Systems Raises $6 Million to Provide Immediate Impact to National Security, led by ARTIS Ventures

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San Francisco, CA, July 07, 2020 (GLOBE NEWSWIRE) — Second Front Systems, a software company working to disrupt the traditional aerospace and defense industry by acting as a beachhead for cutting-edge startups, today announced an oversubscribed $6 million in seed funding led by ARTIS Ventures. Additional investors include Kleiner Perkins, 8VC, Gula Tech Adventures, and Abstract VenturesThe venture funding will be used to expand the capabilities of Second Front’s software platform, Atlas Fulcrum, which has recently received a major contract award from the General Services Administration (GSA) and the Air Force’s AFWERX. The U.S. military recognizes that commercially driven tech, such as autonomy, cyber, biotech, and AI, has surpassed the defense base in relevance to national security in the 21st century. Acting as a “digital prime,” the Atlas Fulcrum platform empowers the U.S. government to regain control from the traditional defense industry in scouting, vetting, and securely fielding cutting-edge technology at scale.Austin Walne, partner at ARTIS Ventures will join Second Front’s board with General Peter Pace, former Chairman of the Joint Chiefs of Staff, General Stanley McChrystal, former commander of U.S. and international forces in Afghanistan, and Alberto Yepez, co-founder and managing director of ForgePoint Capital.
“The U.S. Military is actively seeking advances in artificial intelligence and synthetic biology. This aligns with ARTIS Ventures’ focus on the convergence of computer science and life science,” said Austin Walne, partner at ARTIS Ventures, whose firm is also an investor in Palantir. “Second Front’s executive team comes with proven military backgrounds, giving them an insider’s perspective on vetting and integrating technologies that will have an immediate impact on national security.” 
Second Front was started by former Marine Corps Major Peter Dixon, a scout sniper platoon commander who worked with In-Q-Tel and DARPA to pioneer counter-cartel and counter-insurgency technologies, including early adoption of Palantir, at the State Department and Pentagon, and retired Marine Corps Colonel Mark Butler, a fighter and test pilot who helped form the Marines’ arm of Cyber Command.
“I came back from combat deployments in Iraq and Afghanistan where my men and I were hamstrung by outdated technology that negated what should have been an advantage against insurgent adversaries,” said Second Front CEO Peter Dixon. “Subsequently, at the Pentagon, I watched as billions of dollars were awarded to traditional defense companies, many of whom were unable to deliver usable technology to front-line troops. This venture financing and initial partnerships gives Second Front the velocity to build a new type of ‘lean systems integrator’ that can harness the innovations of the American entrepreneurial ecosystem where the traditional defense firms have failed.” Biotech and the Military 
As the U.S. military looks to reshape the national security and innovation base to respond to pandemics and embrace evolving technologies such as synthetic biology, biotech has become a crucial focus area for the government. 
As stated by Dr. Will Roper, Assistant Secretary of the Air Force for Acquisition, Technology and Logistics in Breaking Defense, “There are so many breakthroughs that are happening. We don’t typically think about biology as a core competency in the Air Force, but biology teaches us a ton.” 
Second Front Systems is a public benefit corporation operating in a new class of venture-backed defense companies that includes Palantir, Anduril, and Rebellion Defense.
About Second Front Systems
Second Front Systems is a veteran-owned small business that builds software so U.S. and allied governments can harness disruptive technology from venture capital-backed, commercially proven companies. For more information visit https://secondfront.com/
About ARTIS Ventures 
ARTIS Ventures (AV) partners with entrepreneurs who are driven to impact the world by reshaping and reinventing industries. The team supports its portfolio companies through their entire life-cycle, from initial venture investment to public offering and beyond. As an early leader in the emerging TechBio sector, ARTIS Ventures funds companies at the intersection of computer science and life science, applying engineering principles and data-enabled discovery to the healthcare space. Notable companies the firm has backed include YouTube, Modern Meadow, Nimble Storage, StemCentrx, Palantir, IDbyDNA, Versa Networks, Cohesity, Locus Biosciences, Eko, Excision BioTherapeutics, Aether, Unnatural Products, Inc., and more. For more information visit www.av.co or email contact@av.co.

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DIAGNOS Announces that its Client in California, the Chaparral Medical Group of Clinics, is Reopening the Screening Services for Diabetic Retinopathy after the COVID-19 Shutdown

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BROSSARD, Quebec, July 07, 2020 (GLOBE NEWSWIRE) — Diagnos Inc. (“DIAGNOS” or the “Corporation”) (TSX Venture: ADK) (OTCQB: DGNOF), a leader in early detection of critical health issues using advanced Artificial Intelligence (AI), is pleased to announce that its client, Chaparral Medical Group (“Chaparral”), is reopening amid additional safety extra measures being implemented to address the COVID-19 situation.
Dr. Prasad Jeereddi, MD, Diabetes Specialist, President, and Medical Director of Chaparral stated: “The remote screenings are conducted using a telemedicine application which temporarily replaces the requirement for patients to be seen in person by a specialist. It only takes 5 minutes to perform the screening test. It prevents the need for the diabetic patient to get their eyes tested in a different location. Chaparral operates 33 clinics across the state of California. Diabetic patients are vulnerable to COVID-19 and the convenience of the test in our clinic reduces the risk for COVID-19 exposure.”Telemedicine refers to the practice of caring for patients remotely when the provider and patient are not physically present with each other.Mr. Yves-Stephane Couture, vice-president of sales at DIAGNOS added: “We are pleased to provide extra service at the point of care (POC) for Chaparral’s patients. While the patient is in the clinic, it’s an excellent opportunity to check their eyes for diabetic retinopathy. Diabetes is the most common cause of vision impairment and blindness among working-age adults in the United States as per the US Centers for Disease Control and Prevention.”
About Chaparral Medical Group

Chaparral Medical Group is a multi-specialty healthcare group serving the communities of Claremont, La Verne, San Dimas, Fontana, Pomona, Rancho Cucamonga, Upland, Chino Hills and Diamond Bar in Southern California. Over 20 primary care physicians serve as the group’s clinical core, and work together with their medical and surgical specialists to provide outstanding care to the patient population of Southern California. They have been serving the community since 1978 and their unwavering commitment to patient care and physician work satisfaction are what have driven them to become the most trusted and relied-upon group of physicians in their area.

About DIAGNOS

DIAGNOS is a publicly-traded Canadian corporation with a mission of early detection of critical health issues through the use of its Artificial Intelligence (“AI”) tool CARA (Computer Assisted Retina Analysis). CARA is a tele-ophthalmology platform that integrates with existing equipment (hardware and software) and processes at the point of care. CARA’s Artificial Intelligence image enhancement algorithms make standard retinal images sharper, clearer and easier to read. CARA is accessible securely over the internet and is compatible with all recognized image formats and brands of fundus cameras and is EMR compatible. CARA is a cost-effective tool for screening large numbers of patients in real-time. CARA complies with local regulations, is FDA cleared for commercialization in the United States of America is Health Canada licensed for commercialization in Canada and is CE marking compliant in Europe.
Additional information is available at www.diagnos.com and www.sedar.comThis news release contains forward-looking information. There can be no assurance that forward-looking information will prove to be accurate, as actual results and future events could differ materially from those anticipated in these statements. DIAGNOS disclaims any intention or obligation to publically update or revise any forward-looking information, whether as a result of new information, future events or otherwise. The forward-looking information contained in this news release is expressly qualified by this cautionary statement.Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.For further information, please contact: Mr. André Larente, President
DIAGNOS Inc.
Tel: 450-678-8882 ext. 224

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