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Cellworks CBM Clinical Study Identifies Novel Biomarkers for ATRA Benefit and Failure in AML Patients

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SOUTH SAN FRANCISCO, Calif., June 04, 2021 (GLOBE NEWSWIRE) — Cellworks Group, Inc., a world leader in Personalized Medicine in the key therapeutic areas of Oncology and Immunology, today announced results from a Cellworks Clinical Trial, in which the Cellworks Computational Omics Biology Model (CBM) accurately predicted that All-Trans Retinoic Acid (ATRA) combined with cytarabine, etoposide, idarubicin (ATRA-CEI) benefits a subset of non-APL (Acute Promyelocytic Leukemia) Acute Myeloid Leukemia (AML) patients. The study also revealed novel biomarkers and key mechanisms of resistance to ATRA-CEI benefit and failure in adults with AML.

The results from this Cellworks clinical trial will be featured in a poster session with comments from Dr. Scott Howard, MD, MSc, University of Tennessee, Health Science Center, as part of the 2021 ASCO Annual Meeting June 4-8th during the Hematologic Malignancies-Leukemia, Myelodysplastic Syndromes, Allotransplant Track and available online as abstract 7027.

ATRA has revolutionized the treatment of APL, and subsequent in vitro data studies showed that some non-APL AML patients may benefit from addition of ATRA to standard therapy. This study aimed to predict ATRA response a priori to determine the optimal treatment for each patient. Cellworks CBM was used to predict and evaluate the impact of initial therapy with ATRA combined with cytarabine, etoposide, idarubicin (ATRA-CEI) to access the biomarkers responsible in adults with AML. The Cellworks CBM biosimulated the downstream molecular effects of cell signaling, drugs and combination therapies on patient-specific in silico cancer cells.

“ATRA plus arsenic trioxide is the standard of care for APL. ATRA also has activity against a subset of non-APL AMLs, so identifying sensitive patients ahead of time allows addition of an additional effective agent whose toxicities are non-overlapping with cytarabine, anthracyclines, and etoposide. Furthermore, understanding the biologic basis of ATRA sensitivity paves the way for even more progress in AML in future studies,” said Dr. Scott Howard, MD, MSc, University of Tennessee, Health Science Center and Co-Principal Investigator for the Cellworks CBM ATRA AML study. “In this study, we aimed to more deeply understand the response to ATRA-CEI in individual non-APL AML patients at the molecular level. Cellworks results were impressive– particularly in uncovering novel biomarkers for ATRA failure/benefit and identifying patient responders who have monosomy 7, where non-response is the norm.”

“Cellworks CBM provides oncologists with an artificial intelligence tool in the clinic capable of revealing oncogenic and transcriptional mechanisms underlying unsuspected drug vulnerabilities and sources of drug resistance,” said Dr. Michael Castro, MD, neuro-oncologist and medical oncologist specializing in molecular oncology, precision medicine, and immunotherapy of cancer at Beverly Hills Cancer Center; Chief Medical Officer for Cellworks Group, Inc.; and Co-Principal Investigator for the Cellworks CBM ATRA AML study. “Cellworks CBM can identify non-APL patients who derive benefit ATRA and avoid its unnecessary use in patients unlikely to respond, thus improving efficacy while reducing toxicity and cost.”

Clinical Study Methods and Results

AML patients in clinical trial NCT00151242 had their leukemia sequenced as part of the trial. Their genomic profiles were used for computational modeling by the Cellworks CBM, which uses curated data about genomic aberrations from PubMed as input to generate disease-specific protein network maps and predict drug responses. Disease biomarkers unique to each patient were identified using the Cellworks therapy biosimulation platform. Digital drug simulations were conducted by measuring the effect of ATRA-CEI on a composite cell growth score of cell proliferation, apoptosis and other hallmarks for cancer. ATRA-CEI was mapped to the patient genome along with a mechanism of action and validated based on the genomic profile and its biological consequences.

Of 171 patients treated with ATRA-CEI, 107 responded (R) and 64 did not respond (NR). Of the 64 NRs, there was a subset of 18 patients with favorable genomic features who did not respond and their non-response was correctly predicted by Cellworks CBM in all 18 cases. Mutations of DNMT3A, EZH2, ASXL, FLT-3 and GART amplification emerged as novel biomarkers of ATRA-CEI failure.

In general, monosomy 7 is expected to confer ATRA resistance due to the presence of EZH2 and KMT2E gene deletions. In this study, 18 of the 32 patients with monosomy 7 did not respond. However, 14 patients with monosomy 7 did respond, and Cellworks identified these patients had co-occurrence of deletions involving IGFBP3, PMS2, HUS1, CDK5, XRCC2/4, AKR1B10 and others that overcame ATRA resistance associated with monosomy 7.

“In this study Cellworks CBM was able to identify non-responders among patients considered likely to respond, and responders among patients considered unlikely to respond,” said Khush F. Mehta, CEO of Cellworks Group, Inc. “By using computational modeling of all genetic biomarkers, we are able to take a holistic view of a patient’s response to drugs, which explains this study’s success versus traditional one-mutation, one drug approaches.”

About Cellworks Group

Cellworks Group, Inc. is a world leader in Personalized Medicine in the key therapeutic areas of Oncology and Immunology. Using innovative multi-omics modeling, computational biosimulation and Artificial Intelligence heuristics, Cellworks predicts the most efficacious therapies for patients. The Cellworks unique biosimulation platform is a unified representation of biological knowledge curated from heterogeneous datasets and applied to finding cures. Backed by UnitedHealth Group, Sequoia Capital, Agilent and Artiman, Cellworks has the world’s strongest trans-disciplinary team of molecular biologists, cellular pathway modelers and software technologists working toward a common goal – attacking serious diseases to improve the lives of patients. The company is based in South San Francisco, California and has a research and development facility in Bangalore, India. For more information, visit www.cellworks.life and follow us on Twitter @cellworkslife.

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Artificial Intelligence

Northern Data Group’s Peak Mining announces new partnership for 28MW of mining, powered by 100% renewable energy

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28MW of miners delivering 1.3 EH/s, strategically located in Paraguay2,860 units of MicroBT’s M63-series liquid-cooled WhatsMiners to be installedPower rate of sub $0.04/kWh, generated by 100% renewable hydropowerFRANKFURT, Germany , May 10, 2024 /PRNewswire/ — Northern Data Group’s Peak Mining today announces a new partnership with Penguin Infrastructure Holding (“Penguin”) for 28MW of mining capacity. This project represents a significant next step in Northern Data Group’s geographical expansion and enables Peak Mining to increase its hashrate, powered by 100% renewable energy.

The hardware will be energized in H2 2024 and marks Peak Mining’s first step into South America. 2,860 units of MicroBT’s M63-series liquid-cooled WhatsMiners will be installed at the site. The hardware will generate 1.3 EH/s, contributing to Peak Mining’s planned growth to 7.9 EH/s this year.
The site in Paraguay is 100% powered by renewable hydropower harnessed from the 14 GW Itaipu Dam, it is the world’s third-largest hydroelectric dam. The site will therefore benefit from the availability of clean energy.
This expansion into South America follows Peak Mining’s recent purchase of a 300MW mining data center site in Corpus Christi, Texas, which will power around 4.2 EH/s of MicroBT’s miners as well as the construction of a 30MW facility in Grand Forks, North Dakota, which will support approximately 1.1 EH/s of the miners.
This selection of sites underscores Northern Data Group’s commitment to meet the demands of the industry as efficiently as possible. Throughout 2024, Northern Data Group will be rapidly expanding its HPC footprint. 
Aroosh Thillainathan, Northern Data Group’s Chief Executive Officer, commented:
“This partnership is significant to Northern Data Group as we continue to execute on our investment strategy and solidify our position within the global High Performance Computing market, and I’m especially pleased to be working with Penguin, given the team’s impressive sustainability standards at this site. It is Peak Mining’s first expansion into South America and is another milestone for the company as it continues to scale its international Bitcoin mining capabilities.”
Niek Beudeker, Managing Director, Peak Mining, commented:
“I’m pleased to partner with Penguin to expand our mining capacity to Paraguay. The Penguin team has done a tremendous job in constructing the site and building a strong local team. This agreement, structured as a partnership, will allow for better alignment of both parties than with a standard hosting arrangement. The partnership demonstrates our commitment to leveraging 100% clean energy to meet growing industry demand, efficiently”.
Björn Schmidtke, CEO at Penguin Group, commented:
“This strategic alliance with Northern Data Group strengthens our position as a leader in hosting next-generation High Performance Computing and also allows us to strengthen our capabilities and expand our offerings in cutting-edge areas such as AI compute. We are committed to advancing in this constantly accelerating world, which demands more high-quality services to keep evolving.”
About Peak Mining
Peak Mining, part of the Northern Data Group, is powering the future of the Bitcoin network. We deliver industry-leading operating and energy efficiency in Bitcoin mining through the latest hardware alongside innovative technology and HPC infrastructure. With our heritage dating back to 2013, we’ve been innovating for over a decade and have been at the forefront of the industry ever since. Our high-quality infrastructure is purpose-built to secure the Bitcoin network, and we’re driven to continuously find new efficiencies driving value for our investors. We’re delivering long term value in more responsible ways.
About Penguin
Penguin Group is at the forefront of HPC and cloud services powered by fully renewable hydro power in South America. Its core value is the mission to Transform Energy into Human Potential. This mission is achieved through Penguin Academy, a revolutionary education concept where students ‘learn by doing’ and has already trained thousands of young people to become the next generation of tech talent. Penguin aims to transform Paraguay into the Technological Hub of South America and expand their concept and mission globally.
About Northern Data Group
Northern Data Group (ETR: NB2) is a leading provider of High Performance Computing (HPC) solutions, utilizing GPU- and ASIC-technology. Our flexible compute power fuels innovation in our three core business platforms: Taiga Cloud, Ardent Data Centers, and Peak Mining. Through our HPC solutions, we pioneer ambitious computing innovation that drives progress in the AI, ML and Generative AI industries. Our close collaboration with industry-leading manufacturers including Gigabyte, AMD, and NVIDIA is fundamental to the acceleration of innovation across sectors including life sciences, financial services, and energy.  

View original content:https://www.prnewswire.co.uk/news-releases/northern-data-groups-peak-mining-announces-new-partnership-for-28mw-of-mining-powered-by-100-renewable-energy-302141597.html

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Sanad Announces Strategic Sale Transaction with CFM Materials, Further Fostering Aviation Industry Collaborations

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Sanad’s sale of two CFM56-7B engines to CFM Materials highlights its ongoing commitment to strengthening industry partnershipsBy partnering with leading aftermarket specialists, Sanad reaffirms its commitment to proactive portfolio management and strategic capital allocationHONG KONG, May 10, 2024 /PRNewswire/ — Sanad, the global aerospace engineering and leasing solutions leader, wholly owned by Abu Dhabi’s sovereign investor Mubadala Investment Company PJSC (Mubadala), unveiled a strategic transaction between Sanad and CFM Materials, the world’s largest provider of used serviceable components for CFM International engines, during the International Society of Transport Aircraft Trading (ISTAT) Asia in Hong Kong.

The sale of two CFM56-7B* engines to CFM Materials underscores Sanad’s strategic shift and proactive approach to strengthening its market position in the aviation industry. Through strategic partnerships with leading aftermarket specialists, Sanad not only reaffirms its commitment but also solidifies its vital role as a key player in shaping the aviation landscape.
This strategic agreement marks a pivotal milestone for the Sanad Leasing division’s ongoing strategy, which was initiated last year with a renewed focus on monetizing existing assets and leveraging the Sanad Leasing division to empower the Sanad MRO division. The primary goal of this strategy is to drive and bolster the growth of the MRO division of Sanad.
Kashish Kohli, Group Chief Financial Officer and SVP Leasing Division at Sanad, said: “We are pleased to announce the successful sale of two CFM56 engines to CFM Materials. This transaction reaffirms our commitment to optimizing our portfolio collaborating with industry leaders like CFM Materials. We are eager to explore further synergies between our respective organizations to explore further avenues of cooperation in the future.”
This collaboration presents new opportunities for CFM Materials to support MRO networks, airlines, lessors, manufacturers, and other service providers worldwide. Adding two CFM56-7B engines to CFM Materials portfolio enables them to meet the increasing demand from customers.
Rudy Bryce, President and CEO of CFM Materials, commented: “This agreement with Sanad strengthens our commitment to support our customers by expanding our lease pool and bolstering our position as a reliable partner to engine owners, operators and CFM56 engine shops around the world.”
With over 35 years of operational excellence and trusted partnerships with over 30 customers across six continents, including world-leading international airlines and global OEMs, Sanad remains at the forefront of aerospace engineering and leasing solutions. The Sanad Leasing division, a key pillar of Sanad’s comprehensive offerings, is committed to providing integrated solutions that address the growth requirements of its partners. Currently, the Sanad Leasing division boasts a substantial portfolio exceeding USD 700 million in assets, showcasing its robust capabilities and dedication to supporting the aviation industry’s evolving needs.
About Sanad
Sanad Group (Sanad) is a global aerospace engineering and leasing solutions leader in Abu Dhabi wholly owned by Mubadala Investment Company PJSC. With more than 35 years of operational experience, Sanad supports leaders in commercial aviation with world-class maintenance, repair, and overhaul (MRO) services and financing solutions. 
Visit us at www.sanad.ae. Follow us on Instagram, Facebook and LinkedIn @TheSanadGroup.
About CFM Materials
Based near DFW Airport, Texas, CFM Materials, a joint venture of GE Aerospace and Safran Aircraft Engines, is the world’s largest provider of used serviceable components for CFM International engines that power the Airbus A320 and Boeing 737 commercial jetliners, as well as the Boeing KC-135R aerial tanker operated by the U.S. Air Force.
In addition to its core operation, the company also sells surplus inventories for CFM International and provides inventory for its parent companies’ MRO (maintenance, repair and overhaul) network around the world. CFM Materials has a global presence with warehouse facilities located near DFW Airport, Texas, Amsterdam, Hamburg, and Singapore; along with sales offices in Singapore and Cardiff, Wales. www.cfmmaterials.com 
*CFM56 engines are a product of CFM International, a 50/50 joint company between GE Aerospace and Safran Aircraft Engines.
Photo: https://mma.prnewswire.com/media/2408079/Sanad_CFM.jpg
For more information, please contact: Raneem Khatib Edelman [email protected] +971 50 204 9791

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CoreWeave Invests £1 Billion in UK; Opens New European Headquarters and Data Centres in London to Bring Cloud Infrastructure to Power the AI Revolution

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LONDON, May 10, 2024 /PRNewswire/ — CoreWeave, the leading specialized cloud provider for AI, today announced that it has opened an office in London as its European headquarters as part of a broader expansion into the continent. The new UK expansion represents a £1 billion investment to bolster the country’s AI potential, and will create job opportunities across engineering, operations, finance and go-to-market. CoreWeave plans to open two UK data centres in 2024 with further expansion planned in 2025.

“We are seeing unprecedented demand for AI infrastructure and London is an important AI hub that we are investing in. Expanding our physical footprint in the UK is an important milestone in the next phase of CoreWeave’s growth,” said Mike Intrator, Cofounder and Chief Executive Officer, CoreWeave. “CoreWeave’s infrastructure will fill a void in the cloud market by providing AI enterprises with localized high-performance compute solutions that will help build and deploy the next generation of AI applications.”  
Prime Minister Rishi Sunak said: “Companies like CoreWeave are powering the future of AI innovation, and I am proud that they’ve backed the UK with a £1 billion investment into UK data centres and have established their European headquarters here – further cementing the UK’s position as an AI and tech superpower.
“We’re leaving no stone unturned to make the UK the best place for pioneering companies like CoreWeave to grow their roots. With the third highest number of AI companies and private investment in AI in the world, it’s clear our plan is working.”
Secretary of State of Science, Innovation, and Technology, Michelle Donelan said: “CoreWeave’s decision to base their European HQ here in London is not just a sign of our tech investment prowess, it is a resounding vote of confidence in our approach to AI and innovation. Today’s £1 billion investment will bring two new data centres to our shores, a vital tool in helping to develop the AI breakthroughs of tomorrow.
“It will also lead to new, highly paid jobs and countless opportunities for our brightest AI minds and start-ups as the UK continues to cement its global AI powerhouse credentials. Our message is clear – when it comes to investment, scaling-up, and innovation, the UK is the perfect home from home.”
CoreWeave’s new European headquarters in London is strategically located given the tremendous AI talent in the UK. The investment in the UK builds on the UK government’s established leadership fostering global awareness and engagement on responsible AI and the country’s commitment to drive investment with plans to upskill millions across the UK in AI. CoreWeave’s presence in the region will support the continued expansion of AI labs and enterprise customers across the UK, bringing much needed computing power to the UK.
CoreWeave’s existing data centres support some of the largest deployments of high-performance GPU clusters in the world, and the infrastructure through which those clusters are consumed is designed with engineers and innovators in mind. Trusted by leading AI labs and enterprises, CoreWeave Cloud manages complexity through automation to deliver the most performant and efficient cloud infrastructure for AI workloads.
About CoreWeave
CoreWeave is a specialized GPU cloud provider, designed to power the most complex workloads with customized solutions at scale. The company’s portfolio of cutting-edge technology delivers a broad range of capabilities for machine learning and AI, graphics and rendering, life sciences, real-time streaming, and more. Its world-class teams, talent, and engineering prowess bring unmatched speed-to-market for advanced compute. CoreWeave operates a growing footprint of data centers covering every region of the US. It was founded in 2017 and is based in New Jersey. Learn more at www.coreweave.com.
Contact
Jackson [email protected] 

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